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The role of microbiota in colorectal cancer

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Abstract

Cancer is one of the most important causes of death throughout the world, and the mortality rate is increasing significantly due to the aging of the population. One of the most common types of cancer is colorectal cancer (CRC). Human microbial ecosystems use metabolism to make important impacts on the body physiology. An intensive literature review was made to investigate the correlations between human gut microbiota and the incidence of CRC. The results of these studies show that there are differences in the composition of microbiota between CRC patients and normal people and the microorganisms in CRC patients are very different from healthy individuals. Therefore, changes in the microbiome can be used as a biomarker for the early detection of CRC. On the other hand, the intestinal flora is may be act as a powerful weapon against CRC in the future.

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Abbreviations

CRC:

Colon rectal cancer

GLOBOCAN2020:

Global Cancer Observatory

HNPCC:

Inherited non-polyp colon disease

ETBF:

Enterotoxigenic Bacteroides fragilis

BFT:

Toxin of B. fragilis

IBD:

Inflammatory bowel disease

CNF:

Cytotoxic necrosis factor

CDT:

Cytolethal distending toxin

PKS:

Polyketide synthases

NTBF:

Non-toxigenic Bacteroides fragilis

ETBF:

Enterotoxigenic B. fragilis

CFS:

Cell-free supernatant

DC:

Dendritic cell

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Acknowledgements

The current work was approved in Infectious and Tropical Diseases Research Center as part of Ph.D thesis of Sakineh Seyed-Mohammadi.

Funding

This work supported by a grant (OG-9724) from Research Affairs, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

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Authors and Affiliations

  1. Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Azar Dokht Khosravi & Aram Asarehzadegan Dezfuli

  2. Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Azar Dokht Khosravi, Sakineh Seyed-Mohammadi & Aram Asarehzadegan Dezfuli

  3. Department of Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Ali Teimoori

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  1. Azar Dokht Khosravi
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Azar Dokht Khosravi and Ali Teimoori contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Sakineh Seyed-Mohammadi. The first draft of the manuscript was written by Azar Dokht Khosravi and Aram Asarehzadegan Dezfuli and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Azar Dokht Khosravi.

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Dokht Khosravi, A., Seyed-Mohammadi, S., Teimoori, A. et al. The role of microbiota in colorectal cancer. Folia Microbiol 67, 683–691 (2022). https://doi.org/10.1007/s12223-022-00978-1

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