Skip to main content
SpringerLink
Log in

Thermosensitive Cotton Textile Loaded with Cyclodextrin-complexed Curcumin as a Wound Dressing

  • Published:
Fibers and Polymers Aims and scope Submit manuscript

Abstract

The moisture conditions and temperature changes are two key factors affecting wound management. Thermosensitive hydrogels are ideal dressing materials since they can maintain a moist environment at the wound site and release additional bioactive molecules to treat the wound when the area is infected. In this study, we developed a novel thermosensitive dressing based on cotton fabric as a matrix to provide robust mechanical properties. Inclusion complexes between cyclodextrins (HP-β-CD, DM-β-CD, and β-CDP) and curcumin were prepared and loaded into the thermosensitive dressing to obtain drug-release properties. The cotton coated with a thermosensitive polymer (CS-g-PVCL) that was crosslinked by citric acid to form a hydrogel was loaded with the appropriate inclusion complex chosen based on phase solubility studies. This composite dressing was investigated to characterize its wound management properties, such as the water vapor permeability and drug release behavior in response to the temperature. The resulting cytotoxicity, antibacterial, and antioxidant properties suggest the potential use of this thermosensitive-hydrogel-functionalized textile as an active wound dressing.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. Gupta, M. Kowalczuk, W. Heaselgrave, S. T. Britland, C. Martin, and I. Radecka, Eur. Polym. J., 111, 134 (2019).

    Article  CAS  Google Scholar 

  2. C. Martin, W. LiLow, A. Gupta, M. Cairul Iqbal Mohd Amin, I. Radecka, S. T Britland, and P. Raj, Curr. Pharm. Des., 21, 43 (2015).

    Article  CAS  PubMed  Google Scholar 

  3. K. Vowden and P. Vowden, Surgery (Oxford), 35, 489 (2017).

    Article  Google Scholar 

  4. T. Abdelrahman and H. Newton, Surgery (Oxford), 29, 491 (2011).

    Article  Google Scholar 

  5. G. Dabiri, E. Damstetter, and T. Phillips, Adv. Wound Care, 5, 32 (2016).

    Article  Google Scholar 

  6. G. Han and R. Ceilley, Adv. Therapy, 34, 599 (2017).

    Article  Google Scholar 

  7. G. D. Winter, Nature, 193, 293 (1962).

    Article  CAS  PubMed  Google Scholar 

  8. M. Fierheller and R. G. Sibbald, Adv. Skin & Wound Care, 23, 369 (2010).

    Article  Google Scholar 

  9. V. Jones, J. E. Grey, and K. G. Harding, BMJ, 332, 777 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  10. X. M. Xu, Y. Liu, W. B. Fu, M. Y. Yao, Z. Ding, J. M. Xuan, D. X. Li, S. J. Wang, Y. Q. Xia, and M. W. Cao, Polymers, 12, 580 (2020).

    Article  CAS  PubMed Central  Google Scholar 

  11. M. Cao, Y. Wang, X. Z. Hu, H. N. Gong, R. H. Li, H. Cox, J. Zhang, T. A. Waigh, H. Xu, and J. R. Lu, Biomacromolecules, 20, 3601 (2019).

    Article  CAS  PubMed  Google Scholar 

  12. M. Cao, Y. Shen, Z. S. Yan, Q. Wei, T. F. Jiao, Y. T. Shen, Y. C. Han, Y. L. Wang, S. J. Wang, Y. Q. Xia, and T. T. Yue, Chem. Eng. J., 405, 126647 (2020).

    Article  CAS  Google Scholar 

  13. N. A. Cortez-Lemus and L. C. Angel, Aust. J. Chem., 70, 1291 (2017).

    Article  CAS  Google Scholar 

  14. S. Çavuş, E. Çakal, and L. M. Sevgili, Chemical Papers, 69, 1367 (2015).

    Article  CAS  Google Scholar 

  15. Q. H. Wu, L. P. Wang, X. F. Fu, X. M. Song, Q. Yang, and G. L. Zhang, Polym. Bull., 71, 1 (2014).

    Article  CAS  Google Scholar 

  16. B. Özkahraman, I. Acar, M. K. Gök, and G. Güçlü, Res. Chem. Intermed., 42, 6013 (2016).

    Article  CAS  Google Scholar 

  17. V. Kozlovskaya, F. Liu, Y. Yang, K. Ingle, and E. Kharlampieva, Biomacromolecules, 20, 3989 (2019).

    Article  CAS  PubMed  Google Scholar 

  18. G. Tang, M. Hu, F. He, D. You, Y. Qian, and Y. Bi, J. Polym. Sci. A Polym. Chem., 56, 300 (2018).

    Article  CAS  Google Scholar 

  19. A. Lumbreras-Aguayo, H. I. Meléndez-Ortiz, B. Puente-Urbina, C. Alvarado-Canch, A. Ledezma, J. Romero-García, and R. Betancourt-Galindo, Carbohydr. Polym., 205, 203 (2019).

    Article  CAS  PubMed  Google Scholar 

  20. S. Ye, L. Jiang, J. Wu, C. Su, and W. Shao, ACS Appl. Mater. Interf., 10, 5862 (2018).

    Article  CAS  Google Scholar 

  21. Y. T. Lin, Y. S. Ting, B. Y. Chen, Y. W. Cheng, and T. Y. Liu, Surf. Coat. Technol., 391, 125663 (2020).

    Article  CAS  Google Scholar 

  22. F. M. Alminderej and Y. El-Ghoul, J. Appl. Polym. Sci., 136, 47625 (2019).

    Article  CAS  Google Scholar 

  23. E. Gholibegloo, T. Mortezazadeh, F. Salehian, A. Ramazani, M. Amanlou, and M. Khoobi, Carbohydr. Polym., 213, 70 (2019).

    Article  CAS  PubMed  Google Scholar 

  24. Y.-H. Yen, C.-M. Pu, C.-W. Liu, Y.-C. Chen, Y.-C. Chen, C.-J. Liang, J.-H. Hsieh, H.-F. Huang, and Y.-L. Chen, Int. Wound J., 15, 605 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  25. H. Soleimani, A. Amini, S. Taheri, E. Sajadi, S. Shafikhani, L. A. Schuger, V. B. Reddy, S. K. Ghoreishi, R. Pouriran, and S. Chien, J. Photochem. Photobiol., 181, 23 (2018).

    Article  CAS  Google Scholar 

  26. R. Moradi-Marjaneh, S. M. Hassanian, F. Rahmani, S. H. Aghaee-Bakhtiari, A. Avan, and M. Khazaei, Curr. Pharm. Des., 24, 4626 (2018).

    Article  CAS  PubMed  Google Scholar 

  27. P. Maiti, L. Paladugu, and G. L. Dunbar, BMC Neurosci., 19, 7 (2018).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  28. S. S. Jambhekar and P. Breen, Drug Discovery Today, 21, 356 (2016).

    Article  CAS  PubMed  Google Scholar 

  29. S. Sharaf and M. E. El-Naggar, Int. J. Biol. Macromol., 133, 583 (2019).

    Article  CAS  PubMed  Google Scholar 

  30. A. Gupta, M. Kowalczuk, C. Martin, H. Gibson, and I. Radecka, Eur. Polym. J., 118, 437 (2019).

    Article  CAS  Google Scholar 

  31. C. S. Mangolim, C. Moriwaki, A. C. Nogueira, F. Sato, M. L. Baesso, A. M. Neto, and G. Matioli, Food Chem., 153, 361 (2014).

    Article  CAS  PubMed  Google Scholar 

  32. X. Z. Sun, X. Wang, J. Z. Wu, and S. D. Li, Appl. Surf. Sci., 403, 509 (2017).

    Article  CAS  Google Scholar 

  33. T. K. Higuchi and A. Connors, Adv. Anal. Chem. Instr., 4, 2 (1965).

    Google Scholar 

  34. X. Z. Sun and N. Wang, Cellulose, 27, 8329 (2020).

    Article  CAS  Google Scholar 

  35. X. Z. Sun, D. H. Bremner, N. Wan, and X. Wang, Appl. Phys. A, 122, 940 (2016).

    Article  CAS  Google Scholar 

  36. A. Celebioglu and T. Uyar, Food Chem., 317, 126397 (2020).

    Article  CAS  PubMed  Google Scholar 

  37. P. Mura, M. T. Faucci, F. Maestrelli, S. Furlanetto, and S. Pinzauti, J. Pharm. Biomed. Anal., 29, 1015 (2002).

    Article  CAS  PubMed  Google Scholar 

  38. G. Narayanan, R. Boy, B. S. Gupta, and A. E. Tonelli, Polym. Test., 62, 402 (2017).

    Article  CAS  Google Scholar 

  39. N. Hedayati, M. Montazer, M. Mahmoudirad, and T. Toliyat, Carbohydr. Polym., 240, 116267 (2020).

    Article  CAS  PubMed  Google Scholar 

  40. S. Natarajan, D. Williamson, A. J. Stiltz, and K. Harding, Am. J. Clinical Dermatol., 1, 269 (2000).

    Article  CAS  Google Scholar 

  41. P. Glampedaki, J. Krägel, G. Petzold, V. Dutschk, R. Miller, and M. M. C. G. Warmoeskerken, Colloids Surf. A Physicochem. Eng. Asp., 413, 334 (2012).

    Article  CAS  Google Scholar 

  42. P. Hu, P. Huang, and M. W. Chen, Arch. Oral Biol., 58, 1343 (2013).

    Article  CAS  PubMed  Google Scholar 

  43. A. Scharstuhl, H. Mutsaers, S. Pennings, W. Szarek, F. Russel, and F. Wagener, J. Cell. Mol. Med., 13, 712 (2009).

    Article  CAS  PubMed  Google Scholar 

  44. C. Mohanty and S. K. Sahoo, Drug Discovery Today, 22, 1582 (2017).

    Article  CAS  PubMed  Google Scholar 

  45. D. Akbik, M. Ghadiri, W. Chrzanowski, and R. Rohanizadeh, Life Sci., 116, 1 (2014).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors acknowledge the financial support from The Education Department of Jilin Province (JJKH20190836KJ) and Jilin Science and Technology Bureau (201831759).

Author information

Authors and Affiliations

  1. Institute of Petrochemical Technology, Jilin Institute of Chemical Technology, Jilin, 132022, China

    Xiao-Zhu Sun, Hai-Dong Wang & Chang Guan

  2. School of Basic Medical, Yunnan University of Chinese Medicine, Kunming Yunnan, 650500, China

    Jun-Zi Wu

Authors
  1. Xiao-Zhu Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jun-Zi Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hai-Dong Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chang Guan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiao-Zhu Sun.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sun, XZ., Wu, JZ., Wang, HD. et al. Thermosensitive Cotton Textile Loaded with Cyclodextrin-complexed Curcumin as a Wound Dressing. Fibers Polym 22, 2475–2482 (2021). https://doi.org/10.1007/s12221-021-0334-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12221-021-0334-1

Keywords

Search

Navigation