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Adiponectin, HOMA-Adiponectin, HOMA-IR in Children and Adolescents: Ouro Preto Study

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Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Objectives

To examine the association and predictive capacity of adiponectin levels, HOMA-AD and HOMA-IR indexes with metabolic risk markers in children and adolescents.

Methods

A cross-sectional study was conducted with 691 children and adolescents (7–14 y), of both sexes. Demographic (sex, age), anthropometric (weight, height, body mass index, waist circumference, body fat), biochemical [total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), triglycerides, fasting glycemia, insulin and adiponectin] and clinical parameters (arterial blood pressure) were analyzed.

Results

In multiple linear regression models, metabolic risk were analyzed in relation to adiponectin levels, HOMA-AD and HOMA-IR. ROC curve analysis was used to define the cut-off for metabolic syndrome for each method studied. Adiponectin level was inversely correlated with weight (r = −0.12; p = 0.01), waist circumference (WC) (r = −0.12; p = 0.01), and triglycerides (r = −0.11; p = 0.02); it was directly correlated with HDL (r = 0.10; p = 0.03) only in the adolescents. In the final linear regression model, after adjustment, only triglycerides (p = 0.03) and HDL (p = 0.04) remained significant. However, HOMA-AD and HOMA-IR were associated with metabolic risk and were the most suitable methods for metabolic syndrome screening in both age groups. For children, independent variables explained 16.0% and 14.5% of HOMA-AD and HOMA-IR, respectively. For adolescents, R2 was higher in HOMA-AD and HOMA-IR models (R2adjusted = 31.9% and R2adjusted = 29.6%, respectively).

Conclusions

HOMA-AD and HOMA-IR are better explained by metabolic markers than adiponectin levels.

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Author information

Authors and Affiliations

  1. Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n - Campus Universitário, Bairro São Pedro, Juiz de Fora, MG, CEP: 36036-900, Brazil

    A. P. C. Cândido

  2. Laboratory of Investigation on Metabolism and Diabetes (LIMED), Gastrocentro, State University of Campinas, Campinas, Brazil

    B. Geloneze, A. Calixto & A. C. J. Vasques

  3. Department of Social and Clinical Nutrition, Federal University of Ouro Preto, Ouro Preto, Brazil

    R. N. Freitas & S. N. Freitas

  4. Laboratory of Epidemiology, Medical School, Federal University de Ouro Preto, Ouro Preto, Brazil

    G. L. L. Machado-Coelho

Authors
  1. A. P. C. Cândido
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  2. B. Geloneze
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  3. A. Calixto
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  4. A. C. J. Vasques
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  5. R. N. Freitas
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  6. S. N. Freitas
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  7. G. L. L. Machado-Coelho
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Contributions

APCC performed the statistical analysis and wrote the paper with contributions from all authors. BG coordinated adiponectin determinations and reviewed the paper. ACJV and AC were responsible for making adiponectin determinations. RNF and SNF coordinated the insulin determinations and reviewed the paper. GLLMC conceived and designed the cross-sectional study, coordinated the project and reviewed the paper. All the authors critically contributed to the discussion and data interpretation, reviewed and approved the final manuscript. GLLMC is the guarantor for this paper.

Corresponding author

Correspondence to A. P. C. Cândido.

Ethics declarations

Ethical Approval

This project was approved by the Institutional Review Board of the Federal University of Ouro Preto (Protocol Number 2004/46). Informed consent was obtained from all individual participants included in the study.

Conflict of Interest

None.

Source of Funding

The authors thank Conselho Nacional de Desenvolvimento Cientifico e Tecnológico, CNPq (Grant n.o 474.965/04) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES for financial support. GLLMC is recipient of a CNPq individual research grant for productivity.

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Cândido, A.P.C., Geloneze, B., Calixto, A. et al. Adiponectin, HOMA-Adiponectin, HOMA-IR in Children and Adolescents: Ouro Preto Study. Indian J Pediatr 88, 336–344 (2021). https://doi.org/10.1007/s12098-020-03444-3

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  • DOI: https://doi.org/10.1007/s12098-020-03444-3

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