Abstract
Primary amebic meningoencephalitis (PAME) is a rare condition, usually caused by free living motile amebae. These are universally fatal infections with very few survivors reported till now. The authors report a 25-d-old boy, the youngest survivor of Naegleria meningitis. The child was admitted with a diagnosis of partially treated meningitis. Cerebro-spinal fluid wet mount examination revealed free living motile amebae resembling Naegleria, which was further confirmed by culture. He was treated with amphoterecin B, rifampicin and fluconazole for 4 wk and ventriculoperitoneal shunt for obstructive hydrocephalous. At 8 mo follow up, child has survived with neurological sequlae.
References
Fowler M, Carter RF. Acute pyogenic meningitis probably due to Acanthamoeba sp.: a preliminary report. Br Med J. 1965;2:740–2.
Hebbar S, Bairy I, Bhaskaranand N, Upadhyaya S, Sarma MS, Shetty AK. Fatal case of Naegleria fowleri meningo-encephalitis in an infant: case report. Ann Trop Paediatr. 2005;25:223–6.
Shenoy S, Wilson G, Prashanth HV, Vidyalakshmi K, Dhanashree B, Bharath R. Primary meningoencephalitis by Naegleria fowleri: first reported case from Mangalore, South India. J Clin Microbiol. 2002;40:309–10.
Rai R, Singh DK, Srivastava AK, Bhargava A. Primary Amebic Meningoencephalitis. Indian Pediatr. 2008;45:1004–5.
Pan NR, Ghosh TN. Primary amoebic meningo-encephalitis in two Indian children. J Indian Med Assoc. 1971;56:134–7.
Singh SN, Patwari AK, Dutta R, Taneja N, Anand VK. Naegleria Meningitis: case report. Indian Pediatr. 1998;35:1012–5.
Tungikar SL, Kulkarni AG, Deshpande AD, Gosavi VS. Primary amoebic meningoencephalitis. J Assoc Physicians India. 2006;54:327–9.
Jain R, Prabhakar S, Modi M, Bhatia R, Sehgal R. Naegleria meningitis: a rare survival. Neurol India. 2002;50:470–2.
Vargas-Zepeda J, Gómez-Alcalá AV, Vásquez-Morales JA, Licea-Amayal L, De Jonckheere JF, Lares-Villa F. Successful treatment of negleria fowleri meningoencephalitis by using intravenous amphoterecin B, fluconazole and rifampicin. Arch Med Res. 2005;36:83–6.
Thong YH. Growth inhibition of Naegleria fowleri by tetracycline, rifamycin and miconazole. Lancet. 1977;2:876.
Conflict of Interest
None.
Role of Funding Source
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yadav, D., Aneja, S., Dutta, R. et al. Youngest Survivor of Naegleria Meningitis. Indian J Pediatr 80, 253–254 (2013). https://doi.org/10.1007/s12098-012-0756-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12098-012-0756-2