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The regulation roles of miRNAs in Helicobacter pylori infection

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Abstract

Helicobacter pylori is a kind of Gram-negative bacteria that parasitizes on human gastric mucosa. Helicobacter pylori infection is very common in human beings, which often causes gastrointestinal diseases, including chronic gastritis, duodenal ulcer and gastric cancer. MicroRNAs are a group of endogenous non-coding single stranded RNAs, which play an important role in cell proliferation, differentiation, autophagy, apoptosis and inflammation. In recent years, relevant studies have found that the expression of microRNA is changed after Helicobacter pylori infection, and then regulate the biological process of host cells. This paper reviews the regulation role of microRNAs on cell biological behavior through different signal pathways after Helicobacter pylori infection.

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Acknowledgements

This work was supported by the Natural Science Foundation of Hunan Province (2020JJ4527, 2019JJ50494), the Scientific Research Fund of Hunan Provincial Education Department (20A438).

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Authors and Affiliations

  1. Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China

    Ting Tong, You Zhou, Qiaoling Huang, Cui Xiao, Qinqin Bai, Bo Deng & Lili Chen

  2. Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China

    Ting Tong, You Zhou, Qiaoling Huang, Cui Xiao, Qinqin Bai, Bo Deng & Lili Chen

  3. Hengyang Engineering Technology Research Center, Hengyang, 421001, Hunan, China

    Ting Tong, You Zhou, Qiaoling Huang, Cui Xiao, Qinqin Bai, Bo Deng & Lili Chen

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TT had the idea for the article and drafted the manuscript. TT, YZ, QH, CX and QB performed the literature search and revised the manuscript. LC critically revised the manuscript. All authors read and approved the final manuscript.

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Tong, T., Zhou, Y., Huang, Q. et al. The regulation roles of miRNAs in Helicobacter pylori infection. Clin Transl Oncol 25, 1929–1939 (2023). https://doi.org/10.1007/s12094-023-03094-9

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