Abstract
To compare and evaluation of surgical operability with and without induction chemotherapy in locally advanced head and neck squamous cell carcinoma. Head and neck malignancy grossly refers to squamous cell carcinomas of head and neck (HNSCC) have multiple treatment modalities and strategies, when opted in an appropriate manner renders tumours curable. The aim of this study is to compare and evaluation of surgical operability with and without induction chemotherapy in locally advanced head and neck squamous cell carcinoma. A prospective observational study involving 50 patients of histologically proven squamous cell carcinoma of head and neck region. Patients were categorized into two major groups, group-1 patients included resectable tumour stage and group-2 included unresectable tumour stage. Both groups were compared after appropriate chemotherapy and surgical intervention. There were a total of 78% males and 22% females with majority of patients in age group of 41–60 years. 54% patients had ulcerative type of growth pattern and most patients had primary site of lesion in oral cavity. 50% patients had moderately differentiated squamous cell carcinoma. Induction chemotherapy was considered in 70% of patients, while majority of patients were belonging to T4N2M0 stage. In this study, we recommend that the borderline category of patients who are initially in an unresectable tumour stage can undergo induction chemotherapy to downstage and shrink the tumour to a resectable stage following which the appropriate surgical intervention should be done with a close monitoring and sustained follow up to prevent recurrence.
Similar content being viewed by others
References
Joshi P, Dutta S, Chaturvedi P, Nair S (2014) Head and neck cancers in developing countries. Rambam Maimonides Med J 5(2):e0009. https://doi.org/10.5041/RMMJ.10143
Masud D, Gilbert P (2009) Secure sterile head drape for head and neck surgery. J Plast Reconstr Aesthet Surg 62(01):143–144
Kulkarni MK (2013) Head and neck cancer burden in India. Int J Head Neck Surg 4:29–35
Guru K, Manoor UK, Supe SS (2012) A comprehensive review of head and neck cancer rehabilitation: physical therapy perspectives. Indian J Palliative Care 18(2):87–97
Franceschi S, Talamani R, Barra S et al (1990) Smoking and drinking in relation to cancer of the oral cavity, pharynx, larynx and oesophagus in Northern Italy. Can Res 50:6502–6507
Blot WJ, McLaughlin JK, Winn DM et al (1988) Smoking and drinking in relation to oral and pharyngeal cancer. Can Res 48:3282–3287
Blot WJ (1992) Alcohol and cancer. Can Res 52(Suppl. 7):2119s-s2123
Krishnamurthy S, Dong Z, Vodopyanov D, Imai A, Helman JI, Prince ME, Wicha MS, Nör JE (2010) Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells. Cancer Res 70(23):9969–78. https://doi.org/10.1158/0008-5472.CAN-10-1712
Scott Brown‟s otorhinolaryngology head & neck surgery, 8th edition volume 3, Head and neck surgery, plastic surgery, chap-24, pp 393
Gregoire V, Lefebvre JL, Licitra L, Licitra L, Felip E (2010) EHNS-ESMO-ESTRO Guidelines Working Group Squamous cell carcinoma of the head and neck: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 21(Suppl. 5):v184–v186. https://doi.org/10.1093/annonc/mdq185
Amin MBES, Greene FL et al. eds, (2017) AJCC Cancer Staging Manual. 8th ed. Springer International Publishing: American Joint Commission on Cancer; New York
Ma J, Liu Y, Yang X et al (2013) Induction chemotherapy in patients with resectable head and neck squamous cell carcinoma: a meta-analysis. World J Surg Onc 11:67
Miller AB, Hoogstraten B, Staquet M, Winkler A (1981) Reporting results of cancer treatment. Cancer 47:207–214
Shukla NK, Deo SVS, Garg PK, Manjunath NML, Bhaskar S, Sreenivas V (2018) Operable oral tongue squamous cell cancer: 15 years experience at a tertiary care center in North India. Indian J Surg Oncol 9(1):15–23. https://doi.org/10.1007/s13193-017-0658-x
Gnanaguru V, Dhanushkodi M, Radhakrishnan V, Kalaiarasi JP, Rajan AK, Selvarajan G, Kesana S, Kothandaraman S, Sekhar S, Vaidhyalingam V, Krishnamurthi A, Nagarajan A, Ramanaiah K, Kumar H, Kumar A, Madhavan R, John A, Ranganathan R, Ganesan TS, Sagar TG (2020) Induction chemotherapy in locally advanced head-and-neck squamous cell carcinoma: real-world outcome. Oncol J India 4:105–9
Tandon P, Dadhich A, Saluja H, Bawane S, Sachdeva S (2017) The prevalence of squamous cell carcinoma in different sites of oral cavity at our Rural Health Care Centre in Loni, Maharashtra - a retrospective 10-year study. Contemp Oncol (Pozn) 21(2):178–183. https://doi.org/10.5114/wo.2017.68628
Dasgupta S, Chakrabarti S, Deb AR (2019) Clinicopathological profile of head and neck squamous cell carcinoma. Indian J Med Paediatr Oncol 40:369–373
Yasin MM, Abbas Z, Hafeez A (2022) Correlation of histopathological patterns of OSCC patients with tumor site and habits. BMC Oral Health 22:305
Dascălu IT et al (2018) Histopathological aspects in oral squamous cell carcinoma. J Dental Sci 3(2):000173
Chinn SB, Spector ME, Bellile EL et al (2014) Efficacy of induction selection chemotherapy vs primary surgery for patients with advanced oral cavity carcinoma. JAMA Otolaryngol Head Neck Surg 140(2):134–142. https://doi.org/10.1001/jamaoto.2013.5892
Gnanaguru V, Dhanushkodi M, Radhakrishnan V, Kalaiarasi JP, Rajan AK, Selvarajan G, Kesana S, Kothandaraman S, Sekhar S, Vaidhyalingam V, Krishnamurthi A, Nagarajan A, Ramanaiah K, Kumar H, Kumar A, Madhavan R, John A, Ranganathan R, Ganesan TS, Sagar TG (2020) Induction chemotherapy in locally advanced head-and-neck squamous cell carcinoma: real-world outcome. Oncol J India 4:105–9
Patil VM, Noronha V, Joshi A, Muddu VK, Gulia S, Bhosale B, Arya S, Juvekar S, Chatturvedi P, Chaukar DA, Pai P, D’cruz A, Prabhash K (2013) Induction chemotherapy in technically unresectable locally advanced oral cavity cancers: does it make a difference? Indian J Cancer 50(1):1–8. https://doi.org/10.4103/0019-509X.112263
Koch WM, Ridge JA, Forastiere A, Manola J (2009) Comparison of clinical and pathological staging in head and neck squamous cell carcinoma: results from Intergroup Study ECOG 4393/RTOG 9614. Arch Otolaryngol Head Neck Surg 135(9):851–858
Rani P, Bhardwaj Y, Dass PK, Gupta M, Malhotra D, Ghezta NK (2015) Neck dissection for oral squamous cell carcinoma: our experience and a review of the literature. J Korean Assoc Oral Maxillofac Surg 41(6):299–305. https://doi.org/10.5125/jkaoms.2015.41.6.299
D’Cruz Anil K, Richa V, Neeti K, Mitali D, Sudeep G, Rohini H, Jai PA et al (2010) Elective versus therapeutic neck dissection in node-negative oral cancer. New England J Med 373(6):521–29
Funding
The authors have no relevant financial or non-financial interests to disclose.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors have no competing interests to declare that are relevant to the content of this article. All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. The authors have no financial or proprietary interests in any material discussed in this article. Authors are responsible for correctness of the statements provided in the manuscript.
Human and Animal Rights
Research involved human participants only, after duly taking informed consent and obtaining ethical clearance from the institution.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Yelishetty, H., Yadav, J.S., Sethi, C. et al. Comparative Evaluation of Surgical Operability with and without Induction Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma. Indian J Otolaryngol Head Neck Surg 76, 626–632 (2024). https://doi.org/10.1007/s12070-023-04230-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12070-023-04230-1