Abstract
Purpose: To study effects of chemoradiation therapy on hearing in patients with malignancy of head and neck. Methods and materials: Patients receiving drugs other than cisplatin as well as those with any otology-related pathology or abnormalities were excluded from the study. Patients with primary biopsy-proven malignancy of the Nasopharynx, Oropharynx, Paranasal Sinuses, Oral Cavity, and Parotid with chemoradiation by cisplatin and different radiation modalities were all eligible. Areas of interest and OARs are indicated on CT images. All patients’ hearing was assessed using pure tone audiometry at the beginning of treatment, at its conclusion, and six months later. Variations in pure tone thresholds from baseline and CTCAE - Common Terminology Criteria for Adverse Events grading are related to cochlear dose. Results: The study involves 75 patients. At cochlear dosage levels of more than 40 Gy, significant SNHL (>10 dB loss) is seen. Absolute PTA threshold values do not statistically differ from baseline to completion at any frequency. For 4000 and 8000 Hz, the absolute PTA threshold values differed from baseline to follow-up, but only for 8000 Hz was the difference statistically significant after six months of follow-up. Following treatment, 64% of patients had grade I CTCAE scoring and 16% and 12%, respectively, had otitis media with effusion and Eustachian tube dysfunction. Conclusion: The inner ear may be harmed in patients receiving radiation to the head and neck. Radiation-induced SNHL typically goes unreported in routine clinical practise because of its long-term nature. In the group of head and neck tumours with high-risk locations, nearly 90% of patients with SNHL were affected. Therefore, it’s critical to reduce cochlear dosage in these patient populations. More investigation is needed to distinguish between cochlear and retro-cochlear types of sensorineural hearing loss.
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References
Fang FM, Chiu HC, Kuo WR, Wang CJ, Leung SW, Chen HC et al (2002) Health-related quality of life for nasopharyngeal carcinoma patients with cancer-free survival after treatment. Int J Radiation Oncology Biol Phys 53(4):959–968
Cai, Grau, Jens Overgaard (1996) Post irradiation sensorineural hearing loss: a common but ignored late radiation complication. Int J Radiation Oncology Biol Phys 36(2):515–517
Zuura CL, Simisb YJW, Verkaikc RS, Schornageld JH, Balmef AJM, Dreschlerb WA et al (2008) Hearing loss due to concurrent daily low-dose cisplatin chemoradiation for locally advanced head and neck cancer. Radiother Oncol 89:38–43
Herrmann F, Dorr W, Muller R, Herrmann T (2006) A prospective study on Radiation-Induced changes in hearing function. Int Radiat Oncol Biol Phys 65(5):1338–1344
Pan CC, Eisbruch A, Lee JS, Snorrason RM, Ten Haken RK, Kileny PR (2005) Prospective study of inner ear radiation dose and hearing loss in head-and-neck cancer patients. Int J Radiat Oncol Biol Phys 61(5):1393–1402
Charlie C, Pan A, Eisbruch JS, Lee RM, Snorrason RK, Ten Haken Paul R, Kileny et al (2005) Prospective study of inner ear Radiation Dose and hearing loss in Head-and-Neck Cancer Patients. Int J Radiation Oncology Biol Phys 61(5):1393–1402
Bhandare N, Antonelli PJ, Morris CG, Malayapa RS, Mendenhall WM (2007) Ototoxicity after radiotherapy for head and neck tumors. Int J Radiat Oncol Biol Phys 67(2):469–479
Petsuksiri J, Sermsree A, Thephamongkhol K, Keskool P, Thongyai K, Chansilp Y et al (2011) Sensorineural hearing loss after concurrent chemoradiotherapy in nasopharyngeal cancer patients. Radiat Oncol 6:19
Honore HB, Bentzen SM, Moller K, Grau C (2002) Sensori-neural hearing loss after radiotherapy for nasopharyngeal carcinoma: individualized risk estimation. Radiother Oncol 65:9–16
Young YH, Chenh PW, Ko JY (1997) A 10-year longitudinal study of tubal function in patients with nasopharyngeal carcinoma after irradiation. Arch Otolaryngol Head Neck Surg 123:945–948
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Yadav, S., Patni, D. & Munjal, V.R. Effects of Chemoradiation Therapy on Hearing in Patients with Malignancy of Head and Neck. Indian J Otolaryngol Head Neck Surg 75, 1950–1953 (2023). https://doi.org/10.1007/s12070-023-03764-8
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DOI: https://doi.org/10.1007/s12070-023-03764-8