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Hyperbilirobinemia and Its Effect on Auditory Perception and Speech Intelligibility in Cochlear Implanted Children (Cochlear Implantation Outcomes in Children Who Have Experienced Hyperbilirobinemia)

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Abstract

The goal of this study was to investigate the probable difference in auditory perception and speech intelligibility performance amongst cochlear implanted children who experienced hyperbilirubinemia or auditory neuropathy in comparison to the cochlear implanted children with unknown etiology for hearing loss. This case–control study was carried out on 106 cochlear implanted children with mean age of 32.36 ± 11.98 months who were purposively selected and allocated into four groups. Out of the total, 30 had no specific etiology for hearing loss, while the others had experienced auditory neuropathy or hyperbilirubinemia with/without blood exchange. The auditory perception and speech intelligibility performance of all the participants who had received auditory verbal therapy were assessed after 6 and 12 months of rehabilitation. Then, the data was analyzed, using the Statistical Package for Social Sciences-version 21(SPSS-21). Results indicated poor auditory perception and speech intelligibility performance of the cochlear implanted children with hyperbilirubinemia and blood exchange (P ≤ 0.05), while the participants in the control group with no specific etiology for hearing loss, the children with hyperbilirubinemia with no blood exchange, and those who suffered from auditory neuropathy performed better, respectively. Also, a significant correlation between auditory neuropathy and hyperbilirubinemia was observed. Despite lower improvement of auditory perception and speech intelligibility of the hearing impaired children who were experiencing moderate to severe degrees of hyperbilirubinemia or auditory neuropathy, cochlear implantation is highly recommended not only for children with unknown etiology for severe hearing loss but also for this group of hearing impaired children.

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Acknowledgements

The authors would like to thank all the cochlear implant centers who collaborated in data collection. The authors wish to thank Mr. H. Argasi at the Research Consultation Center (RCC) of Shiraz University of Medical Sciences for his invaluable assistance in editing this manuscript too.

Funding

No funding was received for conducting this study.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

    Seyed Basir Hashemi & Fatemeh Hoseini

  2. Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran

    Seyed Basir Hashemi & Leila Monshizadeh

  3. Yazd University, Yazd, Iran

    Mehdi Rahimi

  4. Sinus and Surgical Endoscopic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohsen Rajati

  5. ENT and Head & Neck Research Center and Department, Hazrat Rasoul Hospital, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran

    Ahmad Daneshi, Mohammad Farhadi & Hesamaldin Emamdjomeh

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  1. Seyed Basir Hashemi
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  2. Leila Monshizadeh
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  3. Mehdi Rahimi
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  4. Fatemeh Hoseini
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  5. Mohsen Rajati
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  8. Hesamaldin Emamdjomeh
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Contributions

HSB and ML proposed the main concept and idea of the research, performed the research, interoperated the data and wrote the paper and made critical contribution to the concept and design of the research; RM did the statistical analysis and revision related to content of the manuscript. HF, RM, DA, FM, EH, contributed equally in the concept and design of the study and data collection, interpretation of data for the work, investigating and resolving the questions related to the work.

Corresponding author

Correspondence to Leila Monshizadeh.

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Conflict of interest

The authors declare no conflict of interest.

Ethical approval and Consent

All procedures performed in the present study were in accordance with the ethical standards of Shiraz University of Medical Sciences research committee and with the 1964 Helsinki declaration and its later amendments. The study protocol was reviewed and approved by the Ethics Committee of Shiraz University of Medical Sciences, Shiraz, Iran. (Ethic code: IR.SUMS.MED.REC.1399.043).

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Hashemi, S.B., Monshizadeh, L., Rahimi, M. et al. Hyperbilirobinemia and Its Effect on Auditory Perception and Speech Intelligibility in Cochlear Implanted Children (Cochlear Implantation Outcomes in Children Who Have Experienced Hyperbilirobinemia). Indian J Otolaryngol Head Neck Surg 74 (Suppl 3), 4144–4149 (2022). https://doi.org/10.1007/s12070-021-02877-2

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  • DOI: https://doi.org/10.1007/s12070-021-02877-2

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