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Cell sheet transplantation for ischemic heart disease: a systematic review

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Indian Journal of Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript

Abstract

Objective

Cell sheet transplantation is emerging as an appealing alternative for ischemic heart disease patients as it potentially can increase stem cell viability and retention. But the outcomes and safety of this treatment are still limited in literature and the result varies widely. We conduct a systematic review to look at the efficacy and safety of this promising transplantation method.

Methods

A systematic review was performed according to PRISMA guidelines. A comprehensive literature search was undertaken using the PubMed, Scopus, and Embase databases. Articles were thoroughly evaluated and analyzed.

Results

Seven publications about cell sheet transplantation for ischemic heart disease patients were included. The primary outcomes measured were left ventricular ejection fraction (LVEF) and New York Heart Association (NYHA) class. Safety measurement was depicted by cardiac-related readmission and deaths. The follow-up time ranged from 3 to 36 months for clinical outcomes and 8.5 years for safety outcomes. Cell sheet transplantation showed improvement in LVEF and NYHA class in most studies. Cardiac-related readmission and adverse events of cell sheet transplantation range from 0 to 30.4%, all were nonfatal as no cardiac-related death was reported. Patient preoperative status seems can affect the patient’s response to cell sheet therapy.

Conclusion

Cell sheet transplantation can safely improve LVEF and NYHA class in ischemic heart disease patients, even in very low ejection fraction patients with unsuccessful standard therapy before. Further studies with better patient inclusion, larger population, and long-term follow-up required to confirm these results.

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Data Availability

The authors confirm that all the data supporting the findings of this study are currently available in the article.

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Funding

The authors confirm that this research received no external funding.

Author information

Authors and Affiliations

  1. Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, S. Parman Street Cavling 87, Jakarta, Indonesia

    Ahmad Muslim Hidayat Thamrin, Tri Wisesa Soetisna & Andi Nurul Erisya Ramadhani

  2. Faculty of Medicine Syarif Hidayatullah State Islamic University – Haji Hospital, Jakarta, Indonesia

    Ahmad Muslim Hidayat Thamrin & Hari Hendarto

  3. Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia

    Tri Wisesa Soetisna

Authors
  1. Ahmad Muslim Hidayat Thamrin
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  2. Tri Wisesa Soetisna
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  3. Andi Nurul Erisya Ramadhani
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Ahmad Muslim Hidayat Thamrin, Tri Wisesa Soetisna and Andi Nurul Erisya Ramadhani. The first draft of the manuscript was written by Ahmad Muslim Hidayat Thamrin and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Tri Wisesa Soetisna.

Ethics declarations

All authors have read, reviewed, and approved the submitted manuscript to be submitted to the Indian Journal of Thoracic and Cardiovascular Surgery; the manuscript is original and has not been submitted elsewhere in part or in whole.

Ethical statement

This study did not use human or animal subject(s), so ethical clearance was not applied to our study.

Informed consent

This study analyzed previously published data and no new patient data was used. As a result, patient consent was deemed waived.

Conflict of interest

The authors declare no competing interests.

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Thamrin, A.M.H., Soetisna, T.W., Ramadhani, A.N.E. et al. Cell sheet transplantation for ischemic heart disease: a systematic review. Indian J Thorac Cardiovasc Surg 39, 577–587 (2023). https://doi.org/10.1007/s12055-023-01554-z

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  • DOI: https://doi.org/10.1007/s12055-023-01554-z

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