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Synthesis, X-ray structures and cytotoxic effects of a Cu(II)- and a Zn(II) thiosemicarbazones on human epidermoid carcinoma cell A431

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Abstract

Thiosemicarbazone metal complexes [Cu(L)(2-benzpy)]ClO4 (1) and [Zn(L)2] (2) [L = 2-benzoylpyridine-N(4)-methyl-3-thiosemicarbazone), 2-benzpy = 2-benzolylpyridine] were synthesized and X-ray crystallographically characterized. The metal centre in compound 1 has a distorted square planar geometry while in compound 2, the metal centre has a distorted octahedral geometry. Both the molecules induce cytotoxic effects on A431 skin carcinoma cell line in 24 h incubation and significantly enhances hypoploid cell population in cell cycle phase distribution below IC50 dose. Application of both the two molecules exhibit apoptotic induction and genotoxic activity in 24 h exposure.

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Acknowledgements

AC is thankful to PURSE Phase II (Govt. of India) for his fellowship. The single crystal X-ray diffraction facility at USIC, Burdwan University is also gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, The University of Burdwan, Burdwan, 713 104, West Bengal, India

    Chinmoy Biswas, Arnab Chatterjee & Rajarshi Ghosh

  2. Department of Zoology, West Bengal State University, Barasat, Kolkata, 700 126, West Bengal, India

    Sonali Bhattacharya, Deba Prasad Mandal & Shamee Bhattacharjee

Authors
  1. Chinmoy Biswas
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  2. Arnab Chatterjee
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  3. Sonali Bhattacharya
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  4. Deba Prasad Mandal
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  5. Shamee Bhattacharjee
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  6. Rajarshi Ghosh
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Corresponding authors

Correspondence to Shamee Bhattacharjee or Rajarshi Ghosh.

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Supplementary Information

Below is the link to the electronic supplementary material.

12039_2021_1906_MOESM1_ESM.pdf

CCDC 1962661 and CCDC 1962662 contain the supplementary crystallographic data for 1 and 2, respectively. These data can be obtained free of charge via http://www.ccdc.cam.ac.uk/conts/retrieving.html, or from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +441223-336-033; or e-mail: deposit@ ccdc.cam.ac.uk. Figures S1–S7 are available at www.ias.ac.in/chemsci. (PDF 562 kb)

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Biswas, C., Chatterjee, A., Bhattacharya, S. et al. Synthesis, X-ray structures and cytotoxic effects of a Cu(II)- and a Zn(II) thiosemicarbazones on human epidermoid carcinoma cell A431. J Chem Sci 133, 45 (2021). https://doi.org/10.1007/s12039-021-01906-5

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  • DOI: https://doi.org/10.1007/s12039-021-01906-5

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