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Roles of Histone Acetyltransferases and Deacetylases in the Retinal Development and Diseases

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Abstract

The critical role of epigenetic modification of histones in maintaining the normal function of the nervous system has attracted increasing attention. Among these modifications, the level of histone acetylation, modulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), is essential in regulating gene expression. In recent years, the research progress on the function of HDACs in retinal development and disease has advanced remarkably, while that regarding HATs remains to be investigated. Here, we overview the roles of HATs and HDACs in regulating the development of diverse retinal cells, including retinal progenitor cells, photoreceptor cells, bipolar cells, ganglion cells, and Müller glial cells. The effects of HATs and HDACs on the progression of various retinal diseases are also discussed with the highlight of the proof-of-concept research regarding the application of available HDAC inhibitors in treating retinal diseases.

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Acknowledgements

We thank members of Yao laboratory for their kind suggestion and technical assistance.

Funding

This work was supported by the National Natural Science Foundation of China (No. 31970930), Hubei Natural Science Foundation (No. 2020CFA069, No. 2018CFB434), and Neuroscience Team Development Project of Wuhan University of Science and Technology (No. 1180002).

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  1. Jingjing Wang and Shuyu Feng contributed equally to this paper.

Authors and Affiliations

  1. Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology, Wuhan, 430065, China

    Jingjing Wang, Shuyu Feng, Qian Zhang, Huan Qin, Chunxiu Xu, Xuefei Fu, Lin Yan, Yaqin Zhao & Kai Yao

  2. College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China

    Jingjing Wang, Shuyu Feng, Qian Zhang, Huan Qin, Chunxiu Xu, Xuefei Fu, Lin Yan, Yaqin Zhao & Kai Yao

  3. Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, 430065, China

    Kai Yao

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JW and SF: conceptualization, design, writing—original draft, visualization; QZ, HQ, and CX: data curation and review and editing; XF, LY, and YZ: literature search and collection; KY: writing—review and editing, supervision, and funding resources.

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Wang, J., Feng, S., Zhang, Q. et al. Roles of Histone Acetyltransferases and Deacetylases in the Retinal Development and Diseases. Mol Neurobiol 60, 2330–2354 (2023). https://doi.org/10.1007/s12035-023-03213-1

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