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MicroRNA-181b-5p Facilitates Thyroid Cancer Growth via Targeting Programmed Cell Death 4

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Abstract

To explore the potential mechanism of microRNA (miR)-181b-5p promoting the progression of thyroid cancer (TC) by targeting programmed cell death 4 (PDCD4). Analysis of miR-181b-5p and PDCD4 expression in TC was performed. The impact of miR-181b-5p and PDCD4 on proliferation, migration, invasion, and apoptosis of TC cells was examined. The binding relationship between miR-181b-5p and PDCD4 was predicted and verified. miR-181b-5p was up-regulated in TC, while PDCD4 was down-regulated. Down-regulating miR-181b-5p or up-regulating PDCD4 inhibited the proliferation, migration, and invasion of TC cells, and promoted cell apoptosis. PDCD4 was the downstream target of miR-181b-5p, and down-regulation of PDCD4 counteracted the inhibitory effect of down-regulation of miR-181b-5p on the proliferation, migration, and invasion of TC cells and the promoting effect on apoptosis. miR-181b-5p inhibits the proliferation, migration, and invasion of TC cells and promotes cell apoptosis by targeting PDCD4.

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  1. Xiang Geng and Yuan Li have contributed equally to this study.

Authors and Affiliations

  1. Department of Thyroid and Breast Surgery, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou City, 210029, Jiangsu Province, China

    Xiang Geng & Yuan Li

  2. Department of Pathology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou City, 210029, Jiangsu Province, China

    YangYang Sun

  3. Department of General Surgery, Shanghai Tenth People’s Hospital, Clinical Medical College of Nanjing Medical University, 301 Yanchang Middle Road, Shanghai City, 200072, China

    ZhenShun Song

  4. Department of General Surgery, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou City, 210029, Jiangsu Province, China

    Liang Cao

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  1. Xiang Geng
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Geng, X., Li, Y., Sun, Y. et al. MicroRNA-181b-5p Facilitates Thyroid Cancer Growth via Targeting Programmed Cell Death 4. Mol Biotechnol 66, 1154–1164 (2024). https://doi.org/10.1007/s12033-023-01013-5

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