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THSD7A as a Promising Biomarker for Membranous Nephrosis

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Abstract

Membranous nephropathy (MN) is an autoimmune disease of the kidney glomerulus and one of the leading causes of nephrotic syndrome. The disease exhibits heterogeneous outcomes with approximately 30% of cases progressing to end-stage renal disease. Traditionally, the standard approach of diagnosing MN involves performing a kidney biopsy. Nevertheless, kidney biopsy is an invasive procedure that poses risks for the patient including bleeding and pain, and bears greater costs for the health system. The clinical management of MN has steadily advanced owing to the identification of autoantibodies to the phospholipase A2 receptor (PLA2R) in 2009 and thrombospondin domain-containing 7A (THSD7A) in 2014 on the podocyte surface. At present, serum anti-PLA2R antibody detection and glomerular PLA2R antigen staining have been used for clinical diagnosis and prognosis, but the related detection of THSD7A has not been widely used in clinical practice. Here, we summarized the emerging knowledge regarding the roles THSD7A plays in MN and its clinical implications as diagnostic, prognostic, and therapeutic response as well as Methods for detecting serum THSD7A antibodies.

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Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing.

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Authors and Affiliations

  1. Fujian Key Laboratory of Developmental and Neural Biology, College of Life Science, Fujian Normal University, Fuzhou, 350117, Fujian, China

    Shuiqing Jiang, Xiaohong Huang, Ting Li & Yinan Zhang

  2. Kangrun Biotech LTD, Guangzhou, 511400, Guangdong, China

    Dehua Jiang & Zhiyuan Lian

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  1. Shuiqing Jiang
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  2. Dehua Jiang
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Contributions

SJ designed this review and wrote the article, DJ, ZL, TL and YZ contributed to the data collection, SJ and XH revised the article. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Shuiqing Jiang.

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Jiang, S., Jiang, D., Lian, Z. et al. THSD7A as a Promising Biomarker for Membranous Nephrosis. Mol Biotechnol (2023). https://doi.org/10.1007/s12033-023-00934-5

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