Abstract
Elacestrant (RAD-1901), a selective estrogen receptor degrader, was approved by USFDA on January 27, 2023, for the treatment of breast cancer. It has been developed by Menarini Group under the brand name Orserdu®. Elacestrant showed anticancer activity both in vitro and in vivo in ER+ HER2-positive breast cancer models. The present review delebrates the development stages of Elacestrant, with its medicinal chemistry, synthesis, mechanism of action, and pharmacokinetic studies. Clinical data and safety profile has also been discussed, including data from randomized trials.
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Acknowledgements
The authors acknowledge the Department of Science and Technology (DST) for providing the Departmental DST-FIST Grant (SR/FST/LSI-656/2016) to the Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, India.
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ST designed the study and checked and reviewed the manuscript. NB collected the data and wrote the initial draft of the manuscript. ST revised and wrote the final manuscript.
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Bhatia, N., Thareja, S. Elacestrant: a new FDA-approved SERD for the treatment of breast cancer. Med Oncol 40, 180 (2023). https://doi.org/10.1007/s12032-023-02045-2
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DOI: https://doi.org/10.1007/s12032-023-02045-2