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Moderate Prognostic Value of lncRNA FOXD2-AS1 in Gastric Cancer with Helicobacter pylori Infection

  • Original Research
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Abstract

Purpose

Gastric cancer (GC) is one of the most frequent tumors worldwide and identification of a sensitive and specific prognostic biomarker is of great importance. Long non-coding RNAs (lncRNAs) play crucial roles in tumorigenesis of various malignancies. In the present study, we investigated lncRNA FOXD2-AS1 expression in gastric tumors and assessed its potential as a prognostic biomarker.

Methods

A total of 95 tumor and corresponding adjacent non-tumor tissue specimens were collected from patients with GC from Imam Reza hospital, Tabriz, Iran. Total RNA was isolated and FOXD2-AS1 expression was measured using quantitative reverse transcriptase (qRT)-PCR.

Results

FOXD2-AS1 was significantly upregulated in tumor samples as compared to non-tumor tissues (P < 0.0001). In addition, higher expression of FOXD2-AS1 was significantly associated with lymph node metastasis and Helicobacter pylori infection. The receiver operating characteristic (ROC) curve analysis revealed that FOXD2-AS1 might be served as a potential prognostic biomarker for GC.

Conclusion

FOXD2-AS1 is upregulated in gastric tumors and can be used as a valuable biomarker in the prognosis of patients with GC.

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Data Availability

The data are available upon request from the corresponding author.

Code Availability

Not applicable.

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Authors and Affiliations

  1. Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

    Ali Rajabi, Samaneh Tayefeh-Gholami & Reza Safaralizadeh

  2. Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran

    Sepideh Bastani

  3. Zimagene Medical Genetics Laboratory, Avicenna St., Hamedan, Iran

    Melika Maydanchi & Ali Saber

  4. Department of Biology, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran

    Sepehr Abdolahi

Authors
  1. Ali Rajabi
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  2. Sepideh Bastani
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  3. Melika Maydanchi
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  4. Samaneh Tayefeh-Gholami
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  5. Sepehr Abdolahi
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  6. Ali Saber
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  7. Reza Safaralizadeh
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Contributions

AR, AS, and RS designed the study. AR, MM, SB, STG, and SA performed experimental work. AR, MM, AS, and SA performed data analysis. AR, SB, and SA wrote the manuscript with significant input from AS, RS, and MM. AS edited the final draft and provided technical advice. RS supervised the project. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Reza Safaralizadeh.

Ethics declarations

Ethics Approval

The Medical Ethics Committee of the University of Tabriz approved the study (approval number: IR. TABRIZU. REC. 1398.015).

Consent to Participate

Written informed consent was obtained from all patients.

Consent for Publication

All the authors have approved the manuscript for publication in this journal.

Conflict of Interest

The authors declare no competing interests.

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Rajabi, A., Bastani, S., Maydanchi, M. et al. Moderate Prognostic Value of lncRNA FOXD2-AS1 in Gastric Cancer with Helicobacter pylori Infection. J Gastrointest Canc 53, 687–691 (2022). https://doi.org/10.1007/s12029-021-00686-y

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  • DOI: https://doi.org/10.1007/s12029-021-00686-y

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