Abbreviations
- LMWH:
-
Low molecular weight heparin
- DVT:
-
Deep venous thrombosis
- PE:
-
Pulmonary embolism
- TF:
-
Tissue factor
References
Ryan DP, Hong TS, Bardeesy N. Pancreatic adenocarcinoma. N Engl J Med. 2014;371:1039–49. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25207767.
Hidalgo M. Pancreatic cancer. N Engl J Med. 2010;362:1605–17. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20427809.
Majumder S, Thom T, Dasanu CA. Catastrophic arteriovenous thromboembolism as initial manifestation of pancreatic cancer. JOP. 2012;13:231–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22406609.
Khorana AA, Fine RL. Pancreatic cancer and thromboembolic disease. Lancet Oncol. 2004;5:655–63. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15522652.
Schwarzbach CJ, Schaefer A, Ebert A, Held V, Bolognese M, Kablau M, et al. Stroke and cancer: the importance of cancer-associated hypercoagulation as a possible stroke etiology. Stroke. 2012;43:3029–34. Available from: http://stroke.ahajournals.org/content/43/11/3029.long.
Nakchbandi IA, Löhr J-M. Coagulation, anticoagulation and pancreatic carcinoma. Nat Clin Pract Gastroenterol Hepatol. 2008;5:445–55. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18594494.
Kasthuri RS, Taubman MB, Mackman N. Role of tissue factor in cancer. J Clin Oncol. 2009;27:4834–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2764391&tool=pmcentrez&rendertype=abstract.
Kakkar AK, Lemoine NR, Scully MF, Tebbutt S, Williamson RC. Tissue factor expression correlates with histological grade in human pancreatic cancer. Br J Surg. 1995;82:1101–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7648165.
Mandalà M, Reni M, Cascinu S, Barni S, Floriani I, Cereda S, et al. Venous thromboembolism predicts poor prognosis in irresectable pancreatic cancer patients. Ann Oncol. 2007;18:1660–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17660490.
Lee AYY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, et al. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med. 2003;349:146–53. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12853587.
Ben-Aharon I, Stemmer SM, Leibovici L, Shpilberg O, Sulkes A, Gafter-Gvili A. Low molecular weight heparin (LMWH) for primary thrombo-prophylaxis in patients with solid malignancies—systematic review and meta-analysis. Acta Oncol. 2014;53:1230–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25162954.
Pannala R, Basu A, Petersen GM, Chari ST. New-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer. Lancet Oncol. 2009;10:88–95. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2795483&tool=pmcentrez&rendertype=abstract.
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Informed consent was not obtained because patient had died by the time this article was written and patient's remaining family members could not be contacted. However, all individual patient identifiers have been masked without altering clinical or scientific meaning.
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Thapa, S.D., Hadid, H. & Usman, M. Pulmonary Embolism and Stroke as the Initial Manifestation of Advanced Metastatic Pancreatic Adenocarcinoma. J Gastrointest Canc 46, 182–184 (2015). https://doi.org/10.1007/s12029-015-9697-0
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DOI: https://doi.org/10.1007/s12029-015-9697-0