Abstract
Primary hyperparathyroidism in pregnancy is a rare disease that can have detrimental effects on both maternal and fetal/neonatal outcomes. The physiological changes that occur during pregnancy can complicate the diagnosis, imaging examinations, and treatment of this disorder. To enhance our understanding and management of primary hyperparathyroidism in pregnancy, experts from various fields, including endocrinology, obstetrics, surgery, ultrasonography, nuclear medicine, pediatrics, nephrology, and general practice in China, collaborated to develop a consensus addressing the critical aspects of the diagnosis and treatment of primary hyperparathyroidism in pregnancy with a multidisciplinary team approach. This consensus provides valuable guidance for healthcare professionals in managing this condition, ultimately improving outcomes for both mothers and their babies.
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R. Pal, S.K. Bhadada, N. Gupta, A. Behera, N. Aggarwal, A. Aggarwal, K.V. Raviteja, U.N. Saikia, G. Kaur, S.M. Arvindbhai, R. Walia, J. Endocrinol. Invest. 44, 1425 (2021)
A. Song, W. Wang, S. Chen, Y. Wang, S. Liu, M. Nie, Y. Jiang, M. Li, W. Xia, X. Meng, X. Xing, O. Wang, Endocr. Pract. 25, 1127 (2019)
J. Bollerslev, L. Rejnmark, A. Zahn, A. Heck, N.M. Appelman-Dijkstra, L. Cardoso, F.M. Hannan, F. Cetani, T. Sikjær, A.M. Formenti, S. Björnsdottir, C. Schalin-Jantti, Z. Belaya, F.W. Gibb, B. Lapauw, K. Amrein, C. Wicke, C. Grasemann, M. Krebs, E.M. Ryhänen, O. Makay, S. Minisola, S.S.S. Gaujoux, J.-P.P. Bertocchio, Z.K. Hassan-Smith, A. Linglart, E.M. Winter, M. Kollmann, H.-G.G. Zmierczak, E. Tsourdi, S. Pilz, H. Siggelkow, N.J. Gittoes, C. Marcocci, P. Kamenicky, T. Sikjaer, A.M. Formenti, S. Björnsdottir, C. Schalin-Jäntti, Z. Belaya, F.W. Gibb, B. Lapauw, K. Amrein, C. Wicke, C. Grasemann, M. Krebs, E.M. Ryhänen, Ö. Makay, S. Minisola, S.S.S. Gaujoux, J.-P.P. Bertocchio, Z.K. Hassan-Smith, A. Linglart, E.M. Winter, M. Kollmann, H.-G.G. Zmierczak, E. Tsourdi, S. Pilz, H. Siggelkow, N.J. Gittoes, C. Marcocci, P. Kamenický, T. Sikjær, A.M. Formenti, S. Björnsdottir, C. Schalin-Jantti, Z. Belaya, F.W. Gibb, B. Lapauw, K. Amrein, C. Wicke, C. Grasemann, M. Krebs, E.M. Ryhänen, O. Makay, S. Minisola, S.S.S. Gaujoux, J.-P.P. Bertocchio, Z.K. Hassan-Smith, A. Linglart, E.M. Winter, M. Kollmann, H.-G.G. Zmierczak, E. Tsourdi, S. Pilz, H. Siggelkow, N.J. Gittoes, C. Marcocci, P. Kamenicky, Eur. J. Endocrinol. 186, R33 (2022)
P.F. Schnatz, S.L. Curry, Obstet. Gynecol. Surv. 57, 365 (2002)
R.J. Strebeck, A.M. Schneider, D.D. Whitcombe, L.B. Sward, N.K. Dajani, J.R. Whittington, E.F. Magann, Obstet. Gynecol. Surv. 77, 35 (2022)
J. Rigg, E. Gilbertson, H.L. Barrett, F.L. Britten, K. Lust, J. Clin. Endocrinol. Metab. 104, 721 (2019)
A. McCarthy, S. Howarth, S. Khoo, J. Hale, S. Oddy, D. Halsall, B. Fish, S. Mariathasan, K. Andrews, S. O. Oyibo, M. Samyraju, K. Gajewska-Knapik, S.-M. Park, D. Wood, C. Moran, and R. T. Casey, Endocrinol. Diabetes Metab. Case Reports 2019, 19–0039 (2019)
P. Kamenický, A.-L. Lecoq, P. Chanson, Ann. Endocrinol. (Paris). 77, 169 (2016)
Can. Med. Assoc. J. 121, 1193 (1979)
H.-N. Jiao, L.-H. Sun, Y. Liu, J.-Q. Zhou, X. Chen, J.-M. Liu, H.-P. Zhong, BMC Pregnancy Childbirth 21, 576 (2021)
K. Fitch, S.J. Bernstein, M.D. Aguilar, B. Burnand, J.R. LaCalle, P. Lazaro, M. van het Loo, J. McDonnell, J. Vader, J.P. Kahan. The RAND/UCLA Appropriateness Method User’s Manual (RAND Corporation, Santa Monica, CA, 2001)
C.S. Kovacs, Physiol. Rev. 96, 449 (2016)
T. Dahlman, H.E. Sjöberg, E. Bucht, Acta Obstet. Gynecol. Scand. 73, 393 (1994)
R.B. Payne, A.J. Little, R.B. Williams, J.R. Milner, Br. Med. J. 4, 643 (1973)
E. Perin, G. Cacciaguerra, R. Lapenna, C. Catena, L.A. Sechi, D. Marchesoni, Fertil. Steril. 90, 2014.e13 (2008)
J.M. Gertner, D.R. Coustan, A.S. Kliger, L.E. Mallette, N. Ravin, A.E. Broadus, Am. J. Med. 81, 451 (1986)
L.D. Ritchie, E.B. Fung, B.P. Halloran, J.R. Turnlund, M.D. Van Loan, C.E. Cann, J.C. King, Am. J. Clin. Nutr. 67, 693 (1998)
M. Weiss, Z. Eisenstein, Y. Ramot, S. Lipitz, A. Shulman, Y. Frenkel, Br. J. Obstet. Gynaecol. 105, 195 (1998)
U.K. Møller, S. Streym, L. Mosekilde, L. Heickendorff, A. Flyvbjerg, J. Frystyk, L.T. Jensen, L. Rejnmark, Osteoporos. Int. 24, 1307 (2013)
K. Dandurand, D.S. Ali, A.A. Khan, Endocrinol. Metab. Clin. North Am. 50, 753 (2021)
M.S. Ardawi, H.A. Nasrat, H.S. BA’Aqueel, Eur. J. Endocrinol. 137, 402 (1997)
J. Silver, T. Naveh-Many, Pediatr. Nephrol. 25, 2241 (2010)
G. Diaz de Barboza, S. Guizzardi, N. Tolosa de Talamoni, World J. Gastroenterol. 21, 7142 (2015)
L. Sanz-Salvador, M.Á. García-Pérez, J.J. Tarín, A. Cano, Eur. J. Endocrinol. 172, R53 (2015)
M. Kaur, I.M. Godber, N. Lawson, P.N. Baker, D. Pearson, D.J. Hosking, Ann. Clin. Biochem. 40, 508 (2003)
G. Diaz-Soto, A. Linglart, M.-V. Sénat, P. Kamenicky, P. Chanson, Endocrine 44, 591 (2013)
D. Hirsch, V. Kopel, V. Nadler, S. Levy, Y. Toledano, G. Tsvetov, J. Clin. Endocrinol. Metab. 100, 2115 (2015)
S.A. Ghaznavi, N.M.A. Saad, L.E. Donovan, Case Rep. Endocrinol. 2016, 2725486 (2016)
A.R. Jones, M.J. Hare, J. Brown, J. Yang, C. Meyer, F. Milat, C.A. Allan, JBMR Plus 4, e10362 (2020)
D.S. Ali, K. Dandurand, A.A. Khan, J. Clin. Med. 10.2956 (2021)
L. Weizhen, Q. Qingwei, G. Jinsong, L. Juntao, Y. Jianqiu, B. Xuming, Chin. J. Perinat. Med. 20, 268 (2017)
S. Bansal, R.M. Kaushik, R. Kaushik, S. Modi, S. Raghuvanshi, A. Kusum, Gynecol. Endocrinol. 36, 469 (2020)
A. Hernandez, M.S. Petrov, D.C. Brooks, P.A. Banks, S.W. Ashley, A. Tavakkolizadeh, J. Gastrointest. Surg. 11, 1623 (2007)
P.F. Schnatz, S. Thaxton, Obstet. Gynecol. Surv. 60, 672 (2005)
Williams Obstetrics, 25th edn. (McGraw-hill Medical Publishing Division, USA, 2018)
Y. Hu, M. Cui, Z. Sun, Z. Su, X. Gao, Q. Liao, Y. Zhao, Int. J. Endocrinol. 2017, 3947423 (2017)
J. Norman, D. Politz, L. Politz, Clin. Endocrinol. (Oxf.) 71, 104 (2009)
J.S. Gonçalves, L.C. Queiró, J. Soares, C.R. Correia, BMJ Case Rep. 15, e248262 (2022)
V. Dochez, G. Ducarme, Arch. Gynecol. Obstet. 291, 259 (2015)
L. Arnez, V. Lawrence, Endocrinol. Diabetes Metab. Case Rep. 19-0110 (2019)
I.-L. Nilsson, N. Adner, E. Reihnér, C. Palme-Kilander, G. Edstrom, M. Degerblad, J. Women’s. Health (Larchmt.) 19, 1117 (2010)
P. Hession, J. Walsh, G. Gaffney, BMJ Case Rep. bcr2013202883 (2014)
J. Rutkowska, E. Bandurska-Stankiewicz, W. Matuszewski, M. Gowkielewicz, R. Goraj, D. Onichimowski, Endokrynol. Pol. 66, 270 (2015)
P. Ip, Arch. Gynecol. Obstet. 268, 227 (2003)
H.-S. Park, Y.H. Lee, N. Hong, D. Won, Y. Rhee, Front. Endocrinol. (Lausanne). 13, 853171 (2022)
Chinese Society of Osteoporosis and Bone Mineral Research, Chinese J. Osteoporos. Bone Miner. Res. 7, 187 (2014)
I. Capel, I. Mazarico-Altisent, N. Baena, Endocrinol. Diabetes Nutr. 69, 237 (2022)
A.A. Khan, D.A. Hanley, R. Rizzoli, J. Bollerslev, J.E.M. Young, L. Rejnmark, R. Thakker, P. D’Amour, T. Paul, S. Van Uum, M.Z. Shrayyef, D. Goltzman, S. Kaiser, N.E. Cusano, R. Bouillon, L. Mosekilde, A.W. Kung, S.D. Rao, S.K. Bhadada, B.L. Clarke, J. Liu, Q. Duh, E.M. Lewiecki, F. Bandeira, R. Eastell, C. Marcocci, S.J. Silverberg, R. Udelsman, K.S. Davison, J.T.J. Potts, M.L. Brandi, J.P. Bilezikian, Osteoporos. Int. 28, 1 (2017)
A. Eremkina, E. Bibik, S. Mirnaya, J. Krupinova, A. Gorbacheva, E. Dobreva, N. Mokrysheva, Endocrine 77, 556 (2022)
R. Nafisi Moghadam, A.P. Amlelshahbaz, N. Namiranian, M. Sobhan-Ardekani, M. Emami-Meybodi, A. Dehghan, M. Rahmanian, S.K. Razavi-Ratki, Asian Pac. J. Cancer Prev. 18, 3195 (2017)
H. Salhi, T. Bouziane, M. Maaroufi, N.I. Alaoui, H. El Ouahabi, Ann. Afr. Med. 21, 161 (2022)
M. Zhu, Y. He, T. Liu, B. Tao, W. Zhan, Y. Zhang, J. Xie, X. Chen, H. Zhao, L. Sun, J. Liu, Int. J. Endocrinol. 2021, 3108395 (2021)
W. Lizu, L. Liwu, X. Ensheng, G. Shangda, H. Yibin, Y. Jinyan, Chinese J. Med. Ultrasound (Electronic Ed.) 2, 237 (2005)
Z. Wei, Y. Li, L. Ruigang, L. Zhaoyang, W. Bojun, G. Ruijun, Chin. J. Ultrasound Med. 37, 745 (2021)
G. Yuan, W. Jing, F. Lingyun, Y. Cheng, Y. Tianwei, Z. Yanrong, Chin. J. Ultrason. 7, 622 (2015)
J. Liu, W.W. Zhan, J.Q. Zhou, W. Zhou, Clin. Radiol. 75, 179 (2020)
E. Malheiro, N. Chabbert-Buffet, J.-N. Talbot, S. Périé, Eur. Ann. Otorhinolaryngol. Head. Neck Dis. 136, 501 (2019)
T.P.W. McMullen, D.L. Learoyd, D.C. Williams, M.S. Sywak, S.B. Sidhu, L.W. Delbridge, World J. Surg. 34, 1811 (2010)
P. Steenvoorde, E.K. Pauwels, L.K. Harding, M. Bourguignon, B. Marière, J.J. Broerse, Eur. J. Nucl. Med. 25, 193 (1998)
A.F. Saad, L.D. Pacheco, M.M. Costantine, Obstet. Gynecol. 124, 478 (2014)
N. Thanseer, S.K. Bhadada, A. Sood, B.R. Mittal, A. Behera, A.K.R. Gorla, R.R. Kalathoorakathu, P. Singh, D. Dahiya, U.N. Saikia, S.D. Rao, Clin. Nucl. Med. 42, e491 (2017)
T. Kusama, K. Ota, Congenit. Anom. (Kyoto). 42, 10 (2002)
A.N. DiMarco, K. Meeran, I. Christakis, V. Sodhi, C. Nelson-Piercy, N.S. Tolley, F.F. Palazzo, J. Endocr. Soc. 3, 1009 (2019)
T.P. Jacobs, M. Kaufman, G. Jones, R. Kumar, K.-P. Schlingmann, S. Shapses, J.P. Bilezikian, J. Clin. Endocrinol. Metab. 99, 708 (2014)
K.K. Stout, C.S. Broberg, W.M. Book, F. Cecchin, J.M. Chen, K. Dimopoulos, M.D. Everitt, M. Gatzoulis, L. Harris, D.T. Hsu, J.T. Kuvin, Y. Law, C.M. Martin, A.M. Murphy, H.J. Ross, G. Singh, T.L. Spray, Circulation 133, 770 (2016)
A.B. Kaye, A. Bhakta, A.D. Moseley, A.K. Rao, S. Arif, S.J. Lichtenstein, N.T. Aggarwal, A.S. Volgman, R.M. Sanghani, J. Women’s. Health (Larchmt.) 28, 686 (2019)
A. Song, H. Zhao, Y. Yang, S. Liu, M. Nie, O. Wang, X. Xing, J. Endocrinol. Invest. 44, 1667 (2021)
C. Marcocci, J. Bollerslev, A.A. Khan, D.M. Shoback, J. Clin. Endocrinol. Metab. 99, 3607 (2014)
C. Hoover, G.G. Briggs, R.K. Freeman, S.J. Yaffe, L. Williams, Wilkins, J. Midwifery Womens Health 48, 294 (2003)
E. Rey, C.-E. Jacob, M. Koolian, F. Morin, Clin. Case Rep. 4, 1001 (2016)
C. Horjus, I. Groot, D. Telting, P. van Setten, A. van Sorge, C.S. Kovacs, A. Hermus, H. de Boer, J. Pediatr. Endocrinol. Metab. 22, 741 (2009)
R. Krysiak, M. Wilk, B. Okopien, Arch. Gynecol. Obstet. 284, 531 (2011)
R. Koren, O. Neeman, S. Koren, C.A. Benbassat, Arch. Endocrinol. Metab. 62, 125 (2018)
D. Padhi, R. Harris, Clin. Pharmacokinet. 48, 303 (2009)
K.L. Edling, S.G. Korenman, C. Janzen, M.Y. Sohsman, S.K. Apple, S. Bhuta, M.W. Yeh, Endocr. Pract. 20, e14 (2014)
K. Nadarasa, M. Bailey, H. Chahal, O. Raja, R. Bhat, C. Gayle, A.B. Grossman, M.R. Druce, Endocrinol. Diabetes Metab. Case Rep. 2014, 140056 (2014)
L. Vera, S. Oddo, N. Di Iorgi, G. Bentivoglio, M. Giusti, J. Med. Case Rep. 10, 361 (2016)
W.B. Horton, M.M. Stumpf, J.D. Coppock, L. Lancaster, A.C. Dalkin, Z. Liu, C.A. Chisholm, P.W. Smith, S.E. Kirk, J. Endocr. Soc. 1, 1150 (2017)
N. Patlas, G. Golomb, P. Yaffe, T. Pinto, E. Breuer, A. Ornoy, Teratology 60, 68 (1999)
S.B. Green, A.L. Pappas, Am. J. Heal. Pharm. 71, 2029 (2014)
I. Losada, L. Sartori, E. Di Gianantonio, M. Zen, M. Clementi, A. Doria, Autoimmun. Rev. 9, 547 (2010)
R.W. Boyce, A. Varela, L. Chouinard, J.L. Bussiere, G.J. Chellman, M.S. Ominsky, I.T. Pyrah, Bone 64, 314 (2014)
N. Okamatsu, N. Sakai, A. Karakawa, N. Kouyama, Y. Sato, K. Inagaki, Y. Kiuchi, K. Oguchi, T. Negishi-Koga, M. Takami, Biochem. Biophys. Res. Commun. 491, 614 (2017)
S. Ahmad, G. Kuraganti, D. Steenkamp, Am. J. Med. 128, 239 (2015)
M.L. Sandler, R. Ho, M.H. Xing, S. Gidumal, H. Spitzer, J.C. Levy, R.L. Chai, Laryngoscope 131, 1915 (2021)
A.J. Beck, V.M. Reddy, T. Sulkin, D. Browne, Endocrinol. Diabetes Metab. Case Rep. 2022, 10 (2022)
N. Tachamo, B. Timilsina, R. Dhital, T. Lynn, V. Magaji, I. Gabriely, Case Rep. Endocrinol. 2018, 1 (2018)
G.L. Irvin, C.C. Solorzano, D.M. Carneiro, World J. Surg. 28, 1287 (2004)
N. Wenjing, X. Shuhang, W. Jianhua, L. Chao, Int. J. Endocrinol. Metab. 42, 268 (2022)
H.-H. Chai, Y. Zhao, Z. Zeng, R.-Z. Ye, Q.-H. Hu, H.-F. He, J.H. Baek, C.-Z. Peng, Korean J. Radio. 23, 555 (2022)
Z. Chen, L. Cheng, W. Zhang, W. He, Int. J. Hyperth. 39, 466 (2022)
C.-Z. Peng, H.-H. Chai, Z.-X. Zhang, Q.-H. Hu, Z. Zeng, A.-L. Cui, H.-S. Pang, L.-T. Ruan, Int. J. Hyperth. 39, 490 (2022)
Y. Wei, C.-Z. Peng, S.-R. Wang, J.-F. He, L.-L. Peng, Z.-L. Zhao, X.-J. Cao, Y. Li, M.-A. Yu, J. Clin. Endocrinol. Metab. 106, 2707 (2021)
Z. Zubang, X. Yae, S. Runli, J. Zirong, Z. Xueting, Z. Minghua, X. Jinhui, Chin. J. Ultrasound Med. 37, 706 (2021)
A.L. Oliverio, M.A. Hladunewich, Adv. Chronic Kidney Dis. 27, 477 (2020)
G.E. Kleinman, H. Rodriquez, M.C. Good, M.R. Caudle, Obstet. Gynecol. 78, 496 (1991)
A.Y. Glenn Chertow, V. Luyckx, P. Marsden, K. Skorecki, M. Taal, Brenner and Rector’s The Kidney, Elsevier (2019)
C. Camus, C. Charasse, I. Jouannic-Montier, P. Seguin, Y.L. Tulzo, J. Bouget, R. Thomas, Intensive Care Med. 22, 116 (1996)
H.H. Loh, N. Mohd Noor, Case Rep. Crit. Care 2014, 140906 (2014)
D.J. Leehey, T.S. Ing, Am. J. Kidney Dis. 29, 288 (1997)
W.H. van Kuijk, A.W. Mulder, C.H. Peels, G.A. Harff, K.M. Leunissen, Clin. Nephrol. 47, 190 (1997)
S. G. Sharma, S. N. Levine, R. K. Yatavelli, M. A. Shaha, C. A. O. Nathan, J. Endocr. Soc. 4, bvaa015 (2020)
J. Gehlert, A. Morton, Obstet. Med. 12, 175 (2019)
D. Ali, P. Divilly, R. Prichard, D. O’Toole, D. O’Shea, R. K. Crowley, Endocrinol. Diabetes Metab. Case Rep. 20-0130 (2021)
J. Refardt, P. Farina, I. Hoesli, C. Meier, Gynecol. Endocrinol. 34, 833 (2018)
A.A. Khan, B. Clarke, L. Rejnmark, M.L. Brandi, Eur. J. Endocrinol. 180, R37 (2019)
T.L. Leunbach, A.T. Hansen, M. Madsen, R. Cipliene, P.S. Christensen, A.J. Schou, Bone Rep. 14, 100761 (2021)
S. Björnsdottir, B. Clarke, O. Mäkitie, A. Sandström, E. Tiblad, T. Spelman, O. Kämpe, J. Clin. Endocrinol. Metab. 106, 3312 (2021)
M.-H. Tseng, S.-M. Chu, F.-S. Lo, R.-I. Lien, C.-J. Cheng, S.-H. Lin, Pediatr. Nephrol. 31, 753–755 (2016)
Acknowledgements
We thank the consensus review committee for their thorough discussion and critical comments on this consensus. This consensus has already been published in Chinese Journal of Endocrinology and Metabolism 2022,39(1):1–12. https://doi.org/10.3760/cma.j.cn311282-20220930-00563. The Chinese Medical Association takes no responsibility for the accuracy of the translation from the published Chinese original and is not liable for any errors that may occur. No responsibility is assumed, and responsibility is hereby disclaimed, by the Chinese Medical Association for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of methods, products, instructions or ideas presented in this translation. Independent verification of diagnosis and drug dosages should be made. Discussions, views, and recommendations as to medical procedures, choice of drugs and drug dosages are the responsibility of the authors.
Consensus developing committee
Xi Chen4, Ya Hu2, Shan Jian5, Hai-ning Jiao1, Quan Liao2, Jian-min Liu3, Xing-hui Liu6, Hong-wei Ma6, Li-hao Sun3, Ou Wang7, Yu-ying Yang3, Ling-Qing Yuan8, Yi-fan Zhang9, Hui-ping Zhong1, Jian-qiao Zhou10, Min-ting Zhu11
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Zhong, H., Liao, Q., Liu, J. et al. Expert consensus on multidisciplinary approach to the diagnosis and treatment of primary hyperparathyroidism in pregnancy in China. Endocrine 82, 282–295 (2023). https://doi.org/10.1007/s12020-023-03392-w
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DOI: https://doi.org/10.1007/s12020-023-03392-w