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Role of Dendritic Cells in Atopic Dermatitis: An Update

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An Erratum to this article was published on 08 February 2011

Abstract

Dendritic cells (DCs) have been recognized as key players bridging innate and adaptive immune systems. They control the balance of the adaptive immune response, and the functional behavior of DCs is mainly dictated by their microenvironment. Atopic dermatitis (AD) is a paradigmatic disease where the inflammatory microenvironment has a deep impact on DCs. The emergence of IgE-mediated sensitization is tightly related to the impact of locally released cytokines by either keratinocytes, T cells, or other cells involved in the inflammatory reaction. This review will focus on the recent and relevant findings in the field of immunobiology of DCs and their role in AD.

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Acknowledgment

This work was supported in part by grants from the German Research Council (DFG) SFB 704 TP A15.

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Authors and Affiliations

  1. Department of Dermatology and Allergy, University of Bonn Medical Center, Sigmund-Freud-Str. 25, 53127, Bonn, Germany

    Thomas Bieber, Natalija Novak, Nadine Herrman & Susanne Koch

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  1. Thomas Bieber
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  2. Natalija Novak
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  3. Nadine Herrman
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  4. Susanne Koch
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Corresponding author

Correspondence to Thomas Bieber.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s12016-011-8257-z

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Bieber, T., Novak, N., Herrman, N. et al. Role of Dendritic Cells in Atopic Dermatitis: An Update. Clinic Rev Allerg Immunol 41, 254–258 (2011). https://doi.org/10.1007/s12016-010-8224-0

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