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The Daily Intake Levels of Copper, Selenium, and Zinc Are Associated with Osteoarthritis but Not with Rheumatoid Arthritis in a Cross-sectional Study

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Abstract

The present study examined potential association between the daily intake and serum levels of copper (Cu), selenium (Se), and zinc (Zn) and the risk of osteoarthritis (OA) and rheumatoid arthritis (RA) using data from the National Health and Nutrition Examination Survey (NHANES). Daily intake and serum concentrations of Cu, Zn, and Se in 4200 adults from the 2011–2016 NHANES were examined and divided into normal, OA patients, and RA patients. The level of serum Cu was higher in OA and RA than in non-arthritis, while the levels of serum Se and Zn were no different in the three groups. Serum Se and Zn, but not Cu, concentrations were highly correlated with daily intake. Cu, Se, and Zn intake was independently associated with increased risk of OA, but not with RA. And there was a trend for higher odds of OA among participants in the higher Cu, Se, and Zn intake. Future large longitudinal studies are warranted to confirm these findings.

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Data Availability

The datasets generated and/or analysed during the current study are publicly available from the NHANES website. (https://wwwn.cdc.gov/nchs/nhanes/nhanes3/default.aspx).

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Funding

This work was supported by the National Natural Science Foundation of China (No. 82160314), Jiangxi Government Foundation for Youth Natural Sciences (No. 20192BAB215016), and Jiangxi Provincial Department of Education (No. GJJ170154), Health Commission of Jiangxi Provincial, P. R. China (No. 202310503).

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Author notes

  1. Wei-ming Yang and Jiao-feng Lv contributed equally to this work.

Authors and Affiliations

  1. Jiangxi Province Key Laboratory of Laboratory Medicine, Jiangxi Provincial Clinical Research Center for Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China

    Wei-ming Yang, Jiao-feng Lv, Yuan-yuan Wang, Yan-mei Xu, Jin Lin, Jing Liu, Juan-juan Chen & Xiao-zhong Wang

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Contributions

Methodology, data curation, software, and writing—original draft: Weinming Yang and Yuanyuan Wang. Writing—review and editing: Weiming Yang and Yanmei Xu. Conceptualization and writing-review: Jiaofeng Lv, Jing Liu, and Lin Jin. Conceptualization, resources, funding acquisition, and supervision: Juanjuan Chen and Xiaozhong Wang.

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Correspondence to Juan-juan Chen or Xiao-zhong Wang.

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Yang, Wm., Lv, Jf., Wang, Yy. et al. The Daily Intake Levels of Copper, Selenium, and Zinc Are Associated with Osteoarthritis but Not with Rheumatoid Arthritis in a Cross-sectional Study. Biol Trace Elem Res 201, 5662–5670 (2023). https://doi.org/10.1007/s12011-023-03636-w

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  • DOI: https://doi.org/10.1007/s12011-023-03636-w

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