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Recent Update on Active Biological Molecules in Generating the Anticancerous Therapeutic Potential of Garcinia mangostana

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Abstract

The Garcinia mangostana Linn (Mangosteen) is also called as “Queen of Fruits” in Malaysia. It is found in the region of Southeast Asia. It is a medicinal plant that has been used to treat cancer in a variety of cell lines. The mangosteen pericarp possesses distinctive biological properties like anticancer or antitumoral and antioxidant. It has a distinct sweet and sour taste, rich in biological compounds like xanthones. It exhibits various properties like apoptotic in tumor cells which leads to the suppression of their growth and results in their various sizes. The primary purpose of this review article is to summarize the valuable results covered by the researchers so far in the Garcinia mangostana extract and its compound like xanthones. Our focus was to explain the role of the phytoconstituent molecules in invading the cancer pathways to combat the expansion of cells. Furthermore, we still feel that there is a scope for more in silico and in vivo studies to understand and identify the specific site of action in tumoral cells and their mechanistic pathways. In conclusion, Garcinia mangostana can act as an anticancer agent by attacking various molecular pathways.

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Author notes

  1. Neha Verma and KanuPriya contributed equally to this work.

Authors and Affiliations

  1. Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Knowledge park-III, Greater Noida, 201310, U.P.), India

    Neha Verma, Soumya Pandit &  KanuPriya

  2. Center of Medical Biotechnology, Maharishi Dayanand University, Rohtak, Haryana, 124001, India

    Anil Kumar

  3. Department of Biotechnology, Maharaja Agrasen University, Baddi, H.P, India

    Gulab Yadav & Shiv Kumar Giri

  4. Department of Biotechnology, University of Engineering & Management, Kolkata, India

    Dibyajit Lahiri

  5. Faculty of Agro-Based Industry, Department of Agricultural Sciences, Universiti Malaysia Kelantan, Jeli Campus, 17600, Jeli, Kelantan, Malaysia

    Zulhisyam Abdul Kari

  6. Department of Botany, Mahatma Gandhi Central University, Motihari, 845401, Bihar, India

    Ram Prasad

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  1. Neha Verma
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  2. Soumya Pandit
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  3. Anil Kumar
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  4. Gulab Yadav
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  6. Dibyajit Lahiri
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  7. Zulhisyam Abdul Kari
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  8. Ram Prasad
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  9. KanuPriya
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Contributions

NV: data acquisition, planning, review, and revision; SP: data acquisition and tabulation; AK: review and proofreading; GY: review and proofreading; SKG: review and proofreading; DL: review and proofreading, ZAK: review and proofreading, RP: review, editing and proofreading; KP: supervision, review, and proofreading.

Corresponding authors

Correspondence to Ram Prasad or KanuPriya.

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Verma, N., Pandit, S., Kumar, A. et al. Recent Update on Active Biological Molecules in Generating the Anticancerous Therapeutic Potential of Garcinia mangostana. Appl Biochem Biotechnol 194, 4724–4744 (2022). https://doi.org/10.1007/s12010-022-04031-2

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