Treatment Approaches for Functional Neurological Disorders in Children

Purpose of Review Functional neurological disorder (FND) is a multi-network brain disorder that encompasses a broad range of neurological symptoms. FND is common in pediatric practice. It places substantial strains on children, families, and health care systems. Treatment begins at assessment, which requires the following: the medical task of making the diagnosis, the interpersonal task of engaging the child and family so that they feel heard and respected, the communication task of communicating and explaining the diagnosis, and the logistical task of organizing treatment. Recent Findings Over the past decade, three treatment approaches—Retraining and Control Therapy (ReACT), other cognitive-behavioral therapies, and multidisciplinary rehabilitation—have been evaluated in the USA, Canada, and Australia. Of children treated in such programs, 63 − 95% showed full resolution of FND symptoms. The common thread across the programs is their biopsychosocial approach—consideration of biological, psychological, relational, and school-related factors that contribute to the child’s clinical presentation. Summary Current research strongly supports a biopsychosocial approach to pediatric FND and provides a foundation for a stepped approach to treatment. Stepped care is initially tailored to the needs of the individual child (and family) based on the pattern and severity of FND presentation. The level of care and type of intervention may then be adjusted to consider the child’s response, over time, to treatment or treatment combinations. Future research is needed to confirm effective treatment targets, to inform the development of stepped care, and to improve methodologies that can assess the efficacy of stepped-care interventions.


Introduction
Functional neurological disorder (FND) is a multinetwork brain disorder that encompasses a broad range of neurological symptoms [1][2][3]. Presentations with FND are common in pediatric practice-up to 10% of children presenting to pediatric neurology clinics [4] and up to 20% of children presenting to specialist epilepsy clinics [5]. FND places substantial psychosocial, educational, and financial strains on children and their families and a substantial burden on the health care system [6,7]. Motor FND and functional seizures (FS) 1 are the two most common patterns of FND presentations in children [8,9]. Motor FND in children, sometimes comorbid with FS or sensory symptoms, affects the function of the skeletal muscles-muscles that are normally under voluntary control. These presentations include functional limb weakness/paresis, functional movement disorders (uncoordinated or bizarre gaits, functional tremor, tics, chorea, myoclonus, dystonia, and abnormal movements affecting the eyes, face, and jaw), functional voice disorders, swallowing difficulties, regurgitation, and cough. Interestingly, the number of functional tic presentations has surged in 2020 − 2021 in the context of the COVID-19 pandemic [10,11], highlighting the biopsychosocial nature of the disorder and the complex interactions between brain, mind, and body and context. FS take a wide variety of forms-for example, episodic unresponsiveness, shaking of limbs, loss of muscle tone, faint-like events, and altered awareness. The diagnostic process for FND is often undertaken by practitioners (typically neurologists) using current diagnostic criteria [12,13]. The diagnosis is a positive diagnosis: the neurologist elicits, and relies on, positive (rule-in) clinical signs to support the diagnosis (see next section). The ability of neurologists to accurately diagnose FND has been shown to be quite good, with one study finding that pediatric neurology residents providing consultations to the emergency room had approximately 94% accuracy in diagnosing pediatric FND [14]. While neurologists and other physicians play an important role early on, the treatment of pediatric FND is typically the purview of mental health and allied health professionals, including physical, occupational, speech, art, and recreational therapists. Until recently, research in pediatric FND was sparse, but the evidence base is now growing rapidly. This review aims to highlight some of that progress. After discussing the neurology assessment-with a particular focus on motor FND and FS-we review current treatment approaches and their efficacy and make suggestions for future research and the growth and development of treatment services.

Approaches to the Diagnosis of FND: The Neurology Assessment
The treatment of pediatric FND begins with a neurology assessment conducted by a neurologist (or pediatrician) with the following four goals in mind [15,16,17]: the medical task of making the diagnosis (neurology examination and medical workup); the interpersonal task of engaging with the child and family so that they feel heard and respected; the communication task of explaining the findings of the assessment, communicating the diagnosis, and providing information about the treatment that the child needs in order to return to health and well-being; and the logistical task of organizing referrals to ensure that treatment is promptly implemented.

Motor Functional Neurological Disorders
The neurology examination begins informally-in the waiting room, the corridor, or the examination room-with the neurologist taking note of the child's motor function when the child is not being formally examined.
History taking is an important part of the neurology assessment. A preliminary question for the neurologist is whether symptom onset was sudden or insidious. If onset was sudden, then the neurologist is likely to include motor FND high on the differential diagnosis. The neurologist will also ask about the degree of disability and the impact on the child's day-to-day functioning.
After the history is complete, the neurologist begins the examination proper, where they observe or elicit positive (rule-in) signs characteristic of motor FND, enabling the neurologist to make a positive diagnosis. Positive signs and examination techniques that support a motor FND diagnosis include the following: -Discrepancies between the child's movements or level of disability when the child's attention is directed to the symptoms and when they are engaging in automatic tasks such as when checking text messages or during pauses in the examination -Distribution of weakness that is not congruent with a neurological pathway (e.g., arm and leg weakness on opposite sides of the body)  Complete suppression of the functional movements on distraction or on  contralateral ballismic movements requested by the examiner  -An unstable gait, when not a true ataxia (this can be distinguished from  ataxia when the child walks with a narrow base or displays relatively fast  and stable posture and movements when turning around or when bending  over to pick up objects, while demonstrating extreme swaying or forced  steps at other times) For more information about the technical aspects of the neurology examination, see Espay and colleagues [18] and Kozlowska and colleagues [17].
It may be useful for the neurologist to videotape the examination (with the family's permission) or ask for home video recordings of motor events. The recordings can then be reviewed with the child and family to highlight the positive (rule-in) signs that were elicited or observed and that support a diagnosis of motor FND. In presentations with functional tics-as seen more frequently during the current pandemic-teenage onset, female sex, lack of a premonitory urge, and comorbid anxiety, depression, or self-harm behaviors are other suggestive features [10,11,19].
In many contemporary settings, the neurology assessment includes a blood panel and may also include imaging. A baseline blood screen that includes iron studies, B12, vitamin D, thyroid function, and inflammatory markers (documenting low-grade inflammation) is important. Approximately two-thirds of children present with comorbid anxiety, depression, pain, fatigue, and other nonspecific somatic symptoms; factors that contribute to these conditions (e.g., iron deficiency in adolescent girls) may need to be addressed. While imaging may not be medically required, it can be helpful in allaying the concerns of the child, family, and treating team. Even if the results of any investigations are still pending at the time of the assessment, it is important for the neurologist to communicate the clinical diagnosis of motor FND and to discuss with the child and family that findings from the investigations are unlikely to change the diagnosis. Although ancillary investigations such as tremor studies and other neurophysiological tests are used in adult practice (for tremor and myoclonus), their applicability in children is limited by the need for sedation for electrophysiology and also by the lack of testing access and trained providers.
The prognosis of motor FND children is generally good (see studies reviewed in this article). One problematic area involves presentations with fixed dystonia, which is more difficult to treat, and with uncertain outcomes. In two studies with children and adults, 23% and 56.6%, respectively, had improved symptoms [20,21]. In one child cohort-in which all had received intensive multidisciplinary treatment-85% had resolved [22].

Functional Seizures
As in motor FND, history taking is the first step of the neurology assessment and may involve viewing family-provided home videos of FS. Neurologists, Curr Treat Options Neurol (2022) 24: 77 97 especially those familiar with FS, are skilled at identifying clinical features suggestive of FS and, from the outset, include FS high on the differential diagnosis. Common features include asynchronous limb movements (various limbs moving at various times), long duration (e.g., > 10 min), ictal crying, and sudden resolution with no postictal alterations (e.g., confusion and disorientation) [18,[23][24][25]. If the child experiences an event during the consultation-or later during electroencephalogram (EEG)-the forced eyelid closure test (i.e., closed eyelids resisting passive opening), self-protective response to a threat stimulus (e.g., dropping the child's hands over his/her face), or presence of preserved consciousness (during the event the child can hear what those around him or her are saying) [26] are other common features. Another clue suggestive of FS is events that occur only in certain places or situations (e.g., school).
The gold-standard assessment for FS includes a video EEG confirmation that the event is not associated with epileptiform changes [24]. In many clinical settings, access to video EEG may not be available. If so, the neurologist can still make a presumptive diagnosis based on history, clinical features, and an ordinary EEG.
Novel assessment techniques that do not require capturing an event on EEG are also being evaluated. One study found that children with FS (vs. children with epilepsy and healthy controls) maintain activation in the highfrequency bands of the EEG following 3 min of hyperventilation (a physiological stressor) [27]. These findings build on an earlier study finding that children with FS showed dysregulation of their respiratory motor systems and that half the children in the study triggered their FS by hyperventilation [28]. An adult study has recently reported that a panel of immune responseassociated proteins (part of the brain-body stress system), in concert with certain clinical risk factors for FS, may distinguish epileptic from FS episodes with a sensitivity of over 80% and a specificity of over 90% [29]. Whether children show a similar pattern of findings is a subject for future research.

Approaches to the Treatment of FND
Over the past decade, various treatment approaches for children with FND have been described in the literature, including Retraining and Control Therapy (ReACT), other cognitive-behavioral therapies, multidisciplinary rehabilitation, and treatment as usual (Table 1).
With the exception of treatment as usual, which varies widely from one institution or provider to another, these approaches are largely biopsychosocial in character [43,44] (see Text Box 1). As such, they are central to the holistic treatment process required to help children who present with FND [6,45]. Under these biopsychosocial approaches, treating clinicians consider the biological, psychological, relational, and school-related factors-and the interactions between them-that contribute to the child's clinical presentation and that may need to be addressed in treatment (see Text Box 2).

Text Box 1 Key Elements of the Biopsychosocial Approach in Working with Children with FND
In working with children with FND, the biopsychosocial approach includes the following key elements: • A comprehensive assessment with the child and family • In cooperation with the child and family, co-constructing a formulation, which is a summary of the physical, psychological, and social dimensions of the presentation (different system levels) [46,47] • The development of a treatment plan (on one or more system levels), as guided by the formulation Text Box 2 System and Subsystem Levels in the Treatment of FND in Children Biological system level Neurology assessment (including comprehensive medical workup) Neurophysiological regulation (bottom-up interventions) [48,49] Physical therapy [37, 50,51] Occupational therapy [31,52] Speech therapy [31,53] Movement retraining via habit reversal for episodic symptoms [30•] Use of movement and rhythm as neurophysiological and emotional regulation strategies [32,50,51] Psychological/cognitive system level Behavioral interventions that target particular areas via, for example, sleep routines, time scheduling, increasing engagement in enjoyable activities, or decreasing maladaptive behaviors used to avoid or prevent symptoms (sometimes called safety behaviors) * Cognitive approaches that target catastrophic symptom expectations and other maladaptive cognitions, thinking patterns, and psychological processes [30 •, 31] Learning interventions for children with identified learning difficulties Emotion-regulation interventions [32,33] Family system level Biopsychosocial assessment with the child and family Co-construction of a formulation with the child and family Psychoeducation provided to family regarding FND diagnosis and its predisposing, precipitating, and perpetuating factors [30•, 34•, 35, 36•] Redirecting the focus of attention of all family members away from FND symptoms Family interventions to enable the family to support the child's treatment: decreasing family accommodations to the illness, encouraging the child to use regulation strategies/habit-reversal skills, and other strategies independently, and using motivators to reinforce functional skills and adaptive skills, and to minimize the sick role [30 •, 34•, 35] Other formal family therapy interventions to address family conflict, marital conflict, unresolved grief issues, or issues pertaining to maltreatment Social system level Reintegration into social life (e.g., time with friends, sports, dance, band) Curr Treat Options Neurol (2022) 24: 77 97 -Attendance/reintegration at the child's school, which may require a broad range of school-based interventions and collaboration with the school Development of a brief social script to respond if peers ask about symptoms Interventions with youth group leaders Interventions pertaining to social media abuse (with child protection services or police) Child protection interventions (with child protection services) * An example of maladaptive behavior that is used to avoid symptoms (= safety behaviors) include a child's having to leave school early and take a nap if he or she child feels strange, in order to prevent a functional seizure

Retraining and Control Therapy for Functional Seizures
In 2020, Fobian and colleagues published the first and only randomized, controlled trial (RCT) for any pediatric FND treatment [30•]. The study evaluated the efficacy of ReACT, a short-term, outpatient, cognitive-behavioral therapy (CBT)-based intervention for functional seizures (FS), versus supportive therapy, in 29 randomized participants (ReACT n = 17; supportive therapy n = 12). After an average of 4.6 ReACT sessions, all children in the ReACT group had complete resolution of FS episodes at 7 days posttreatment, with 82% remaining FS-free at 60 days posttreatment. These outcomes were significantly better than the supportive therapy group, which had no significant improvement in FS in the 7 days posttreatment.
ReACT aims to target sense of control and catastrophic symptom expectations and is the first treatment for FND to use principles of habit reversal to retrain physical symptoms. ReACT includes four main components: (1) psychoeducation based on the integrated etiological summary model [54], (2) an individually tailored patient plan to retrain FS symptoms by increasing the child's sense of control through the use of behaviors incompatible with FS and by challenging catastrophic symptom expectations, (3) a family plan for responding to FS episodes by monitoring for safety while otherwise minimally attending to the child and not interfering with the child's retraining plan (in [2] above), and (4) a plan to return to school and other social activities.

Cognitive-Behavioral Therapy as Part of a Pediatric, Stepped-Care Pathway
General CBT has been evaluated as part of a pediatric, stepped-care pathway for children with FS in two recent studies [36•, 40]. The efficacy of CBT in and of itself was not specifically assessed since it was a component of a broader, stepped-care multimodal treatment program. The intervention included one or more of the following: education regarding the diagnosis, bottom-up regulation interventions (e.g., slow-breathing biofeedback), CBT (including trauma-focused CBT when needed), psychiatric medication for comorbid anxiety or depression, intervention for learning difficulties, family therapy, and (for a small subset) inpatient admission. At discharge from the treatment program, 59 − 63% of the children had full remission, and 21 − 28% had Although CBT is often thought of as a single treatment, the term CBT includes a wide range of techniques that vary by the individual patient, the disorder being treated, and the specific mechanisms being targeted (see Text Box 3) [55]. Moreover, the "dominant assumptions, methods, and goals" of CBT have also changed over time [56,57,58]. Consequently, in the absence of an established manualized intervention, the procedures and techniques used in various CBT treatments likely also vary by the individual therapist and the target of the treatment (see Text Box 3). These differences likely affect the outcomes of the different interventions. Additional research is needed to determine the most effective treatment targets, identify which CBT components best effect change on those targets, and develop clear guidelines for using CBT for treating FND [59].

Wave 1: Behavior therapy
In the first wave, behavior therapy methods focus on changing overt behavior by observing, predicting, and modifying behavior to promote health and well-being. Behavior therapy involves learning through association and utilizing reinforcement and punishment to modify behaviors. This wave is based on the work of Ivan Pavlov, Burrhus Frederic Skinner, and John Watson.

Wave 2: Classic CBT
The second wave of CBT-based on the work of Albert Ellis and Aaron Beck-focuses on the top-down link between maladaptive cognitions and behaviors; the goal is to detect and alter these existing maladaptive patterns and to develop more adaptive ones by identifying, labeling, and reframing cognitive distortions. This wave of CBT also acknowledges the role of behavior in reinforcing cognitions and feelings and incorporates bottom-up techniques such as exposure and habit reversal.

Wave 3: Acceptance CBT
The third wave of CBT is focused on the person's relationship to thought and emotion more than the content itself.
It emphasizes mindfulness (beginning with the work of Jon Kabat-Zinn), emotions, acceptance, values, and metacognition. This wave involves top-down, mindfulness-based, and emotion-regulation strategies in which the child utilizes intentional efforts to increase attention and awareness capacities for better control of thoughts and feelings. The objective in third-wave CBT is to help the individual learn to live with painful or unpleasant sensations and with pain in the world and to accept how things are instead of suffering by trying to change them. grams accepted all children disabled by FND whatever their presentationsclinicians working in these programs put particular emphasis on the role of the biopsychosocial assessment and formulation to understand the particular situation of each child and to guide the treatment process [34•, 35, 37].

Treatment as Usual (Unspecified)
Some treatment outcomes for treatment as usual or otherwise unspecified interventions are available as part of outcome studies that involve longitudinal follow-up in pediatric FND [8,41,42]. A US follow-up study of children  Table 1). Outcomes were very good, with 63 − 95% of children attaining full remission of FND symptoms (see Table 1). Each multidisciplinary rehabilitation program involved the same key elements in the following domains: focus of treatment, multidisciplinary team/interventions, and post-discharge planning. (1) Focus of treatment. All programs implemented a variety of interventions-physical, psychological, family, and school-to facilitate return to normal function. Function was assessed via the Functional Independence Measure for Children (WeeFIM), Global Assessment of Functioning (GAF), participation in school activities, or decreased frequency of health care utilization (e.g., hospital admissions).
(2) Multidisciplinary team/interventions. All programs used, as needed, physical therapy/occupational therapy, psychotherapy with the child, family therapy, recreational activities, and schoolwork or attendance at the hospital school. In some programs, the role of physiotherapy went beyond restoration of motor function: formalized exercise programs were used to build physical resilience, autonomic regulation, and stress resistance and to contribute to subjective well-being [50,51]. Psychotherapy with the child included a broad range of approaches. Bottom-up approaches [48,49,60] were used to help the child regulate the body's neurophysiological state [34•]. Top-down approaches such as CBT or talking therapy were used to help with maladaptive thoughts or to work through unresolved grief or other interpersonal issues, respectively [48,49,60]. If required, trauma-specific interventions such as Eye Movement Desensitization and Reprocessing (EMDR), radical exposure tapping, or trauma-focused CBT were also used [48,49,60]. (3) Post-discharge planning. Every inpatient program developed a home discharge plan with the families involving the continuation of step-down supports (e.g., outpatient therapy, follow-up) and school reintegration planning in order to consolidate and maintain functional gains.
Importantly, because most multidisciplinary rehabilitation programs treated children with a broad mix of symptoms and presentations-the pro-Curr Treat Options Neurol (2022) 24: 77 97 with FS found that 36% of children had remission within 6 months (sustained at 2 years) and that 33% never attained remission [41]. No information about treatment was available. A UK study of children with mixed FND reported symptom improvement in 90% of children available at 1-year follow-up (51% of the sample) [8]. As part of treatment as usual, 79% of the children in this cohort had been treated through inpatient admissions, and 69% had a child psychiatrist involved in their care. In another UK study, which evaluated long-term outcomes of FND from childhood to adulthood, Raper and colleagues [42] found that 23% of their sample showed evidence of FND in adulthood at a sufficient level to be documented in their medical records [42]. That level of FND symptoms maintained into adulthood highlights the need for the use of the biopsychosocial interventions discussed above. Table 1 shows that rates of comorbid mental disorders vary substantially from one cohort to another (22 − 80%) [8,38,61]. As with FND that does not resolve, chronic comorbid mental health conditions are associated with long-term effects on social adjustment and health and well-being [6]. Of the studies reviewed in this article, only one study (from Australia) reported long-term outcomes [38]. Kozlowska and colleagues found that 10/57 (18%) of children who had presented with mixed FND 4 years earlier suffered from ongoing mental health problems and lower scores on the Global Assessment of Functioning-despite recovery from FND in 9/10 children. A previous Turkish study had likewise shown that over a third (14/40 or 35%) of children with mixed FND met criteria for an anxiety or mood disorder 4 years later, despite good recovery from FND (34/40 or 85%) [62]. These data suggest that, in a subset of patients, follow-up treatment interventions may need to address comorbid mental health issues long after the resolution of FND.

Discussion
This review presents a decade of progress in the treatment of children and adolescents with FND. During that time, studies from the USA, Canada, and Australia have documented treatment outcomes from three contemporary specialist treatment programs. Of children treated in such programs, 63 − 95% showed full resolution of FND symptoms. The common thread across the programs is the biopsychosocial approach [43,44], which has guided the development of different treatment programs across countries and clinical contexts. Today, as a consequence, we have a rich diversity of treatment models and programs. While all the models are embedded in the biopsychosocial model, each program prioritizes certain system levels (see Text Box 2)-or Curr Treat Options Neurol (2022) 24: 77 97 combines interventions on different system levels in different ways-and provides interventions that have been developed to target those system levels.
Progress notwithstanding, much remains to be done. In the remainder of the discussion, we explore some of the challenges pertaining to the treatment of children with FND that face clinicians, researchers, patients, and health care settings. We hope that our discussion of the challenges and issues will help continue the momentum of change.

Strengthening the Evidence-Base for Clinical Practice
Large, well-conducted RCTs provide the most reliable evidence about treatment efficacy. Currently only one pilot RCT, with a sample of 29-and 60-day follow-up, has been published. This trial provides good preliminary evidence supporting the efficacy of ReACT for children with FS in an outpatient setting. Additional well-powered RCTs are needed, however, to confirm the long-term efficacy of ReACT and other the interventions described above and to identify the most effective treatment targets for individual patients.
A challenge for pediatric researchers is the pervasive heterogeneity of FND regarding all the following domains: FND symptoms, symptom combinations, and levels of functional impairment; comorbid functional somatic symptoms (e.g., pain, fatigue, orthostatic intolerance); comorbid anxiety, depression, and other mental health disorders; and finally, predisposing, precipitating, and perpetuating factors. This complexity in patient presentations is common in many medical and mental health disorders, such as depression, addiction, and hypertension [63,64,65,66,67]. And it is a complexity that demands the development of adaptive interventions-a type of stepped-care approach [63,64]-in which the treatment is individually designed, with the treatment strategy, setting, or intensity continually adjusted, over time, to optimize treatment response.
The development of adaptive treatments for pediatric FND may provide enhanced treatment outcomes for patients by providing ways of adjusting treatment for patients who have long-standing or severe symptoms, notable functional impairment, poor treatment response, or multiple comorbidities or complexities. Unfortunately, however, the use of multiple interventions makes RCTs difficult to design and conduct and in any event potentially confounds the outcomes. Recently, to address these issues, sequential, multipleassignment, randomized trials (SMART) have been used to study adaptive interventions by randomizing participants to different orders of interventions based on specific "decision rules" about when to vary a participant's treatment [68,69]. The use of SMART designs in the development of FND interventions will allow controlled evaluation of the most effective ways to tailor individual treatment and to determine the most effective combination of interventions. Given that studies in children indicate that prompt diagnosis and treatment are associated with better outcomes [38,41], using SMART designs in research, where all the treatment options are considered to be potentially effective active interventions, would eliminate the need to Curr Treat Options Neurol (2022) 24: 77 97 randomize participants to treatment as usual or other control conditions that are known to be ineffective. The results of such research may ultimately help to reduce attrition rates in treatment, as patients who are not benefiting from one treatment will be moved in a timely manner to the next step in a determinate sequence of evidence-based treatments. An alternative to SMART is to evaluate the effectiveness of an intervention systematically across different FND subtypes in consecutive or parallel RCTs.

Developing a Flexibility of Treatment Models in a Variety of Health Care Contexts
Overall, this review highlights that flexibility is needed in implementing treatment models for pediatric FND. Figure 1 summarizes a stepped-care approach to treatment.

Limitations
The key limitation of this review is the worldwide dearth of services for FND. 2 The programs and studies described here reflect the work of individual clinicians-or groups of clinicians-and their local efforts to work with and change service delivery in their health care settings. The dearth of services results, in part, from long-standing stigma, the ingrained belief that patients with FND do not suffer from a real (organic) disorder and that they therefore do not require, or even deserve, treatment [31,71]. In the wake of recent research advances [1][2][3], however, far-reaching educational efforts are currently under way to ensure that neurologists and other physicians understand FND as a multi-network brain disorder involving complex interactions between biological, psychological, and social components. Efforts are also under way to promote collaboration between neurologists, mental health clinicians, physical therapists, and other allied health professionals to enable provision of holistic (biopsychosocial) treatment. Nevertheless, compared to other areas of health care, the ongoing shortfall in funding and service delivery for FND-coupled with the time lags associated with research translation-is enormous, leaving patients with FND, worldwide, struggling to obtain adequate treatment.

Conclusion
Research on pediatric FND treatment provides strong support for current clinical practice. It also offers a foundation for a stepped approach to treatment.
Stepped care coupled with a biopsychosocial formulation serves as a framework for an individualized treatment process in pediatric FND. Within the context of available health care resources, stepped care is initially tailored to the needs of the individual child (and family) based on the pattern and severity of FND presentation. The level and type of intervention are then adjusted to take into account the child's response, over time, to particular treatments or treatment combinations (see Fig. 1). Future research is needed to confirm effective treatment targets, to inform the development of stepped care, and to improve methodologies that can assess the efficacy of stepped-care interventions. More broadly, the health care system needs to improve access to treatments and treatment providers and to undertake further efforts to reduce patient-and provider-related stigma relating to FND and other functional disorders.

Funding
Open Access funding enabled and organized by CAUL and its Member Institutions. Aaron D. Fobian is currently supported by NIMH 1R61MH127155 (PI) "Retraining and Control Therapy (ReACT): Sense of control and catastrophic symptom expectations as targets of a cognitive behavioral treatment for pediatric psychogenic non-epileptic seizures (PNES)" and NIDDK 1K23DK106570 (PI). Neither of these funding sources had a specific role in supporting this manuscript. No other funding was received to assist with the preparation of this manuscript.

Conflict of Interest
Areti Vassilopoulos declares that she has no conflict of interest. Shekeeb Mohammad declares that he has no conflict of interest. Leon Dure declares that he has no conflict of interest. Kasia Kozlowska declares that she has no conflict of interest. Aaron D. Fobian declares that he has no conflict of interest [11].

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The study demonstrates that prompt diagnosis, followed by prompt multidisciplinary assessment, engagement, and treatment (including bottom-up regulation strategies), is associated with improved outcomes in children/adolescents with functional seizures. 35. Kozlowska