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From Psoriasis to Psoriatic Arthritis: Ultrasound Insights Connecting Psoriasis with Subclinical Musculoskeletal Inflammation and the Path to Psoriatic Arthritis

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Abstract

Purpose of Review

This review summarizes the literature about the transition from psoriasis to psoriatic arthritis (PsA), focusing on musculoskeletal ultrasound (MSUS) for detecting subclinical inflammation and its role in diagnosis and triage of high-risk patients.

Recent Findings

MSUS effectively detects subclinical musculoskeletal inflammation in patients with psoriasis; however, some of these lesions are non-specific and can be found in healthy individuals. Preliminary evidence suggest that subclinical sonographic findings may predict progression to PsA in psoriasis patients. MSUS can also improve referrals’ accuracy and its integration in the PsA classification criteria may improve early PsA detection.

Summary

MSUS is a valuable tool for detecting subclinical abnormalities in psoriasis patients, which indicate an increased likelihood of progressing to PsA. Its integration into referral protocols and clinical use could improve PsA diagnosis. We propose an MSUS-inclusive algorithm for PsA referrals and triage, which requires validation. The potential of early intervention in reducing PsA progression in psoriasis patients with subclinical inflammation remains to be established.

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Data Availability

No datasets were generated or analysed during the current study.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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  1. A. L. Ribeiro and L. Eder contributed equally to this work.

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  1. Department of Medicine, Women’s College Research Institute, Women’s College Hospital, University of Toronto, 76 Grenville Street Room 6326, Toronto, Ontario, M5S 1B2, Canada

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LE and ALR wrote the main manuscript text and ALR prepared figure and table. All authors reviewed and approved the manuscript.

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LE received grants from Abbvie, UCB, Janssen, Pfizer, Eli Lilly, Novartis, Fresenius Kabi and consultation fees from Abbvie, UCB, Janssen, Pfizer, Eli Lilly, Novartis, BMS ALR have no conflicts

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Ribeiro, A.L., Eder, L. From Psoriasis to Psoriatic Arthritis: Ultrasound Insights Connecting Psoriasis with Subclinical Musculoskeletal Inflammation and the Path to Psoriatic Arthritis. Curr Rheumatol Rep (2024). https://doi.org/10.1007/s11926-024-01146-9

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