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Increased Risk of Preeclampsia with Assisted Reproductive Technologies

  • Preeclampsia (A Kattah, Section Editor)
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Abstract

Purpose of Review

We summarized recent available data to assess the association between assisted reproductive technology (ART) and risk for preeclampsia.

Recent Findings

The majority of clinical studies supporting the association of preeclampsia and ART are retrospective. Published data from both clinical and pre-clinical studies suggest specific ART procedures may contribute to the increased risk, including in vitro embryo handling and development, hormone stimulation, transfer cycle types, and use of donor oocytes/embryos. Potential mechanisms include epigenetic aberrations leading to abnormal placentation, absence of factors secreted by the corpus luteum, and immunologic responses to allogenic gametes.

Summary

There is an increased risk of preeclampsia following ART. Treatment plans that favor reduced preeclampsia risk should be considered for ART pregnancies. To make ART pregnancies safer, additional clinical and animal model studies are needed to elucidate the underpinnings of this risk association.

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Acknowledgements

This work was supported by Oregon Health and Science University Reproductive Endocrinology and Infertility Fellowship (M.S.K), Oregon Health and Science University/Oregon National Primate Center start-up funds (L.A.V), and the Medical Research Foundation of Oregon (L.A.V and S.B.G).

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Authors and Affiliations

  1. Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR, USA

    Molly S. Kornfield

  2. Division of Nephrology & Hypertension, Department of Medicine, Oregon Health & Science University, Portland, OR, USA

    Susan B. Gurley

  3. Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Ave, Beaverton, OR, USA

    Lisa A. Vrooman

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  1. Molly S. Kornfield
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Correspondence to Lisa A. Vrooman.

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Molly S. Kornfield, Susan B. Gurley, and Lisa A. Vrooman declare that they have no conflict of interest.

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Kornfield, M.S., Gurley, S.B. & Vrooman, L.A. Increased Risk of Preeclampsia with Assisted Reproductive Technologies. Curr Hypertens Rep 25, 251–261 (2023). https://doi.org/10.1007/s11906-023-01250-8

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