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The Role of Large Animal Models in Cardiac Regeneration Research Using Human Pluripotent Stem Cell-Derived Cardiomyocytes

  • Regenerative Medicine (SM Wu, Section Editor)
  • Published:
Current Cardiology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Heart failure leads to high mortality. The failing myocardium cannot often be rescued as heart regeneration is mostly compromised by disease progress. Stem cell therapy is a strategy under development to replace the impaired myocardium for recovery after heart injury.

Recent Findings

Many studies have provided evidence of the beneficial effects of pluripotent stem cell-derived cardiomyocyte (CM) implantation into diseased rodent hearts, but there are still many challenges and limitations to replicating the same effects in large animal models for preclinical validation.

Summary

In this review, we summarize progress in the use of pluripotent stem cell-derived CMs in large animal models based on three key parameters: species selection, cell source, and delivery. Most importantly, we discuss the current limitations and challenges that need to be solved to advance this technology to the translational stage.

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Acknowledgements

Yu-Feng Hu reports support for the present manuscript from Academia Sinica (AS-TM-110-01-01) and National Science and Technology Council (111-2628-B-A49A-502).

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Authors and Affiliations

  1. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

    Yuan-Yuan Cheng, Yu-Feng Hu & Patrick Ching-Ho Hsieh

  2. Graduate Institute of Medical Genomics and Proteomics and Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan

    Patrick Ching-Ho Hsieh

  3. Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    Yu-Feng Hu

  4. School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

    Yu-Feng Hu

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Cheng, YY., Hu, YF. & Hsieh, P.CH. The Role of Large Animal Models in Cardiac Regeneration Research Using Human Pluripotent Stem Cell-Derived Cardiomyocytes. Curr Cardiol Rep 25, 325–331 (2023). https://doi.org/10.1007/s11886-023-01857-y

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