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Evaluation of liver and spleen stiffness measurement with shear wave elastography in brucellosis

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Abstract

Background

Human brucellosis, which is endemic in the eastern region of Turkey, infects the reticulo-endothelial system. Acute brucellosis may cause hepatomegaly or splenomegaly.

Aims

The main purpose of this study was to investigate the effectiveness of the point shear wave elastography (pSWE) method in identifying and detecting liver and spleen stiffness in acute brucellosis.

Methods

This case–control study included 40 patients with acute brusellosis and 60 healthy individuals as a control group. The demographic data, abdominal ultrasonography (USG) and pSWE results of the patient and control groups were evaluated. Statistical and ROC analyses were performed.

Results

The liver pSWE value was 3.8395 ± 1.171 kPa in the patient group and 1.6619 ± 0.495 kPa in the control group. The spleen pSWE value was 3.2431 ± 1.803 kPa in the patient group and 1.3793 ± 0.622 kPa in the control group. The mean liver and spleen pSWE values were statistically significantly higher in the patient group than in the control group (p < 0.001). Cut-off values were determined as 2.524 for the liver pSWE and 1.62667 for the spleen pSWE. From the AUC values (0.959, 0.903), the diagnostic performance of liver and spleen pSWE values were seen to be excellent in distinguishing between patient and control groups.

Conclusions

The study results showed that liver and spleen stiffness were high in acute brucellosis patients and had predictive significance above certain cut-off values. It can be considered that pSWE, which evaluates liver and spleen stiffness in acute brucellosis, may provide diagnostic benefit as a reliable, non-invasive technique.

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Data availability

Data are available from the authors on request.

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Authors and Affiliations

  1. Department of Radiology, Harran University, Sanliurfa, 63300, Turkey

    Ferit Dogan, Mehmet Celik, Betul Amasyali Cosandal, Burak Turac & Mehmet Resat Ceylan

  2. Department of Statistics, Faculty of Science, University of Mugla Sıtkı Kocman, Mugla, Turkey

    Nevin Guler Dincer

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  1. Ferit Dogan
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Correspondence to Ferit Dogan.

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Dogan, F., Celik, M., Cosandal, B.A. et al. Evaluation of liver and spleen stiffness measurement with shear wave elastography in brucellosis. Ir J Med Sci 193, 1521–1526 (2024). https://doi.org/10.1007/s11845-023-03577-2

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