Abstract
Aloe vera is a medicinal plant widely used for biomedical, pharmaceutical, and cosmetic applications. Oodles studies are going on to evaluate the protective role of Aloe vera while treating it along with different adjuvants compounds/drugs or plants. Therefore, here we aimed to illuminate the combined effect of Aloe vera and Vitamin E against CCl4-induced toxicity. Rats treated with CCl4 displayed reduced body weight, impaired peripheral and cellular (serum/tissues) redox/defense system, abnormal liver function tests, and abnormal histology (liver/Brain); the effect was rescued by the Aloe vera (ethanolic extract) treatment. However, the adjuvant treatment of Vitamin E significantly enhanced the anti-toxic impact of Aloe vera by attenuating free radical production, boosting antioxidants enzyme activities, and improving liver and brain tissues histology. Our findings suggest that Vitamin E enhances the beneficial effects of Aloe vera and could be used as an adjuvant.
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Data availability
All data generated or analyzed during this study are included in this published article.
Abbreviations
- CCl4:
-
Carbon tetrachloride
- ROS:
-
reactive oxygen species
- SOD:
-
superoxide dismutase
- CAT:
-
Catalase
- EAV:
-
ethanolic extract of Aloe vera
- ANOVA:
-
Analysis of variance
- AST:
-
Aspartate transaminase
- ALT:
-
alanine aminotransferase
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This work was supported by IBBt, UVAS.
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RF and HA performed the experiments, MSY, data analysis, IU helped in the experiment. IM and WS helped in chemicals and manuscript. TA supported the study, written the manuscript, corresponding authors, reviewed and approved the manuscript, and held all the responsibilities related to this manuscript. All authors reviewed and approved the manuscript.
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Fatima, R., Yasin, M.S., Anwar, H. et al. Vitamin E boosted the protective potential of Aloe vera in CCl4-treated rats. Biologia 77, 269–276 (2022). https://doi.org/10.1007/s11756-021-00932-5
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DOI: https://doi.org/10.1007/s11756-021-00932-5