Skip to main content

Advertisement

SpringerLink
Log in

Uncommon presentation of systemic capillary leak syndrome: a case report with pulmonary embolism

  • IM - CASE RECORD
  • Published:
Internal and Emergency Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Zhang W, Ewan PW, Lachmann PJ (1993) The paraproteins in systemic capillary leak syndrome. Clin Exp Immunol 93:424–429. https://doi.org/10.1111/j.1365-2249.1993.tb08195.x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Cheung PC, Eisch AR, Maleque N et al (2021) Fatal exacerbations of systemic capillary leak syndrome complicating coronavirus disease. Emerg Infect Dis 27:2529–2534. https://doi.org/10.3201/eid2710.211155

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Pothen L, Rouvière H, Poncin R et al (2014) Systemic capillary leak syndrome revealing a diffuse large B-cell lymphoma. Acta Clin Belg 69:305–308. https://doi.org/10.1179/0001551214Z.00000000076

    Article  CAS  PubMed  Google Scholar 

  4. Kapoor P, Greipp PT, Schaefer EW et al (2010) Idiopathic systemic capillary leak syndrome (Clarkson’s disease): the Mayo Clinic experience original article. Mayo Clin Proc 85:905–912. https://doi.org/10.4065/mcp.2010.0159

    Article  PubMed  PubMed Central  Google Scholar 

  5. Marra AM, Gigante A, Rosato E (2014) Intravenous immunoglobulin in systemic capillary leak syndrome: a case report and review of literature. Expert Rev Clin Immunol 10:349–352. https://doi.org/10.1586/1744666X.2014.882771

    Article  CAS  PubMed  Google Scholar 

  6. Gousseff M, Arnaud L, Lambert M et al (2011) The systemic capillary leak syndrome: a case series of 28 patients from a European registry. Ann Intern Med 154:464–471. https://doi.org/10.7326/0003-4819-154-7-201104050-00004

    Article  PubMed  Google Scholar 

  7. Xie Z, Kuhns DB, Gu X et al (2019) Neutrophil activation in systemic capillary leak syndrome (Clarkson disease). J Cell Mol Med 23:5119–5127. https://doi.org/10.1111/jcmm.14381

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Pineton De Chambrun M, Luyt CE, Beloncle F et al (2017) The clinical picture of severe systemic capillary-leak syndrome episodes requiring ICU admission. Crit Care Med 45:1216–1223. https://doi.org/10.1097/CCM.0000000000002496

    Article  PubMed  Google Scholar 

  9. Druey KM, Parikh SM (2017) Idiopathic systemic capillary leak syndrome (Clarkson disease). J Allergy Clin Immunol 140:663–670. https://doi.org/10.1016/j.jaci.2016.10.042

    Article  PubMed  Google Scholar 

  10. Ghurye RR, Khan A, Yung T et al (2020) Successful treatment of a patient with chronic systemic capillary leak syndrome, neutropenia and thymoma. J Clin Immunol 40:240–244. https://doi.org/10.1007/s10875-019-00722-4

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The patient described in this case report gave her consent for the publication of this manuscript.

Author information

Authors and Affiliations

  1. Internal Medicine Residency Program, School of Medicine, University of Insubria, Varese, CO, Italy

    Matteo Molteni & Valentina Pelitti

  2. Internal Medicine Unit, ‘Sant’Anna’ Hospital, ASST Lariana, Como, Italy

    Matteo Galli & Alessandro Squizzato

  3. Thoracic Surgery Unit, ‘Circolo e Fondazione Macchi’ Hospital, ASST Sette Laghi, Varese, Italy

    Davide Di Natale

  4. Internal Medicine Unit, ‘San Paolo’ Hospital, University of Milan, Milan, Italy

    Gianmarco Podda

  5. Research Center on Thromboembolic Disorders and Antithrombotic Therapies, University of Insubria, Varese, CO, Italy

    Alessandro Squizzato

  6. U.O.C. Medicina Generale, Ospedale Sant’Anna-ASST Lariana, Via Ravona, 20, 22042, San Fermo Della Battaglia, CO, Italy

    Alessandro Squizzato

Authors
  1. Matteo Molteni
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Valentina Pelitti
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Matteo Galli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Davide Di Natale
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gianmarco Podda
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Alessandro Squizzato
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alessandro Squizzato.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest related to the publication of this manuscript.

Human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

The patient gave her consent for the publication of this manuscript.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 33 KB)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Molteni, M., Pelitti, V., Galli, M. et al. Uncommon presentation of systemic capillary leak syndrome: a case report with pulmonary embolism. Intern Emerg Med (2023). https://doi.org/10.1007/s11739-023-03479-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s11739-023-03479-2

Search

Navigation