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Simple and feasible design of a polymeric nanoparticle for efficient anticancer drug delivery

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Abstract

In this paper, we present a simple and feasible drug self-assembled delivery system with pH responsiveness and targeting function for cancer therapy. The drug delivery system is composed of an anticancer drug and an amphiphilic random copolymer based on phenylboronic acid, galactose, and polyethylene glycol monomethyl ether acrylate molecules and achieved through reversible addition–fragmentation chain transfer polymerization. The micelles present targeting function by introducing galactose molecules and show pH sensitivity on the basis of the interactions between phenylboronic acid and galactose molecules. Particle size, transmission electron microscopy, and drug release assays show the pH-responsive behavior of micelles at pH 6.0. Cellular uptake assay demonstrates that micelles can internalize HepG2 cells via receptor-mediated interaction. In addition, the drug-loaded micelles can considerably inhibit cancer cell proliferation as indicated by in vivo antitumor assay. The synthesized micelles may facilitate the development of valid drug delivery systems for cancer therapy.

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Acknowledgements

This work was supported by Effect of serum exosome circ-RPPH1 on paclitaxel resistance of breast cancer and its mechanism.

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Authors and Affiliations

  1. Guiyang Hospital of Guizhou Aviation Industry Group, Guiyang, 550006, Guizhou Province, China

    Yue Zhao, Rui Zhong, Yongqiang Fu, Zhenlin Zhou, Ming Yang & Lina He

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  1. Yue Zhao
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  2. Rui Zhong
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  3. Yongqiang Fu
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  4. Zhenlin Zhou
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  5. Ming Yang
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  6. Lina He
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Correspondence to Yue Zhao.

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Zhao, Y., Zhong, R., Fu, Y. et al. Simple and feasible design of a polymeric nanoparticle for efficient anticancer drug delivery. Chem. Pap. 75, 4035–4044 (2021). https://doi.org/10.1007/s11696-021-01589-9

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  • DOI: https://doi.org/10.1007/s11696-021-01589-9

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