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LC–ESI–MS/MS analysis, biological effects of phenolic compounds extracted by microwave method from Algerian Zizyphus lotus fruits

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Abstract

Jujube fruit is a considerable source of antioxidants that could be used as ingredients against several diseases. The optimization of microwave-assisted extraction (MAE) of bioactive compounds from Z. lotus pulp and peel (Zlp) was achieved using response surface methodology. The effect of the extraction parameters (microwave power “MW”, extraction time, ethanol/water solvent and liquid–solid ratio) on the total phenolic compounds (TPC) was well described by second-degree regression model. The liquid chromatography-high resolution tandem mass spectrometry (LC–MS–MS) was done. Best results were obtained at 600 W MW power, 180 s irradiation time, 51% ethanol concentration and 47:1 mL/g solvent-to solid ratio obtaining 7473.38 ± 740.55 mg GAE/100 g of TPC, 1019.96 ± 75.03 mg CE/100 g of TFC, 14,253.11 ± 2453.86 mg CE/100 g of TTC. LC–MS–MS determined that from all phytochemicals, 44.51% of the extract was flavonoids which represent 80.75% of all secondary metabolites from which 5-hydroxy-7-O-nerylflavanone is found to be the most abundant one. The extracts revealed the presence of 34 bioactive compounds, from which 10 phenolic compounds have never been previously identified from Zizyphus plant. The Zlp extract exhibited a greatest antioxidant effects by PAOT, DPPH, and FRAP activity; as well as, a lowest cytotoxic effects against both HepG2 and MCF-7 cells. In a concentration of 1 mg/mL, Zlp produced a strong AChE inhibition. This research revealed that MAE is more rapid and an effective method to extract TPC recovery which can be used in food matrixes and/or in nutraceutical formulations for its good biological effect.

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Acknowledgements

This research was supported by the ministry of the higher education and scientific research and the faculty of Natural Sciences, Life and Earth Sciences, University of Bouira, Algeria; the Portuguese Foundation for Science and Technology, FCT, through the Research Unit grant UID/MULTI/04046/2019 to BioISI; FCT project PTDC/BIA-BQM/28355/2017; BioISI MassSPEC Facility.

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Authors and Affiliations

  1. Laboratoire de Gestion et Valorisation des Ressources Naturelles et Assurance Qualité, Faculté des Sciences de la Nature et de la vie et des Sciences de la Terre, Université de Bouira, 10000, Bouira, Algeria

    Farida Berkani, Amina Abbou, Nourelimane Benzitoune, Meriem Adouane & Lotfi Mouni

  2. Département de Biologie, Faculté des Sciences de la Nature et de la Vie et des Sciences de la Terre, Université de Bouira, 10000, Bouira, Algeria

    Farid Dahmoune & Nabil Kadri

  3. Laboratoire de Biomathématiques, Biophysique, Biochimie, et Scientométrie (L3BS), Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, 06000, Bejaïa, Algeria

    Farid Dahmoune, Nabil Kadri & Sabiha Achat

  4. Faculty of Sciences, BioISI—Biosystems & Integrative Sciences Institute, University of Lisbon, 1649-004, Lisbon, Portugal

    Maria Luísa Serralheiro & Asma Ressaissi

  5. Departamento de Química e Bioquímica, Faculty of Sciences, University of Lisbon, Campo Grande, 1749-016, Lisbon, Portugal

    Maria Luísa Serralheiro

  6. Institut Européen des Antioxydants, University of Nancy, 18 rue Victor de Lespinats, 54230, Neuves-Maisons, France

    Mouna Kaci & Smail Meziane

  7. Centre de Recherche en Technologies Agro-alimentaires, Route de Targua Ouzemmour, 06000, Béjaia, Algérie

    Khodir Madani

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  1. Farida Berkani
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Correspondence to Farida Berkani.

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Berkani, F., Dahmoune, F., Kadri, N. et al. LC–ESI–MS/MS analysis, biological effects of phenolic compounds extracted by microwave method from Algerian Zizyphus lotus fruits. Food Measure 16, 3354–3371 (2022). https://doi.org/10.1007/s11694-022-01437-8

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  • DOI: https://doi.org/10.1007/s11694-022-01437-8

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