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Translational application of neuroimaging in major depressive disorder: a review of psychoradiological studies

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Abstract

Major depressive disorder (MDD) causes great decrements in health and quality of life with increments in healthcare costs, but the causes and pathogenesis of depression remain largely unknown, which greatly prevent its early detection and effective treatment. With the advancement of neuroimaging approaches, numerous functional and structural alterations in the brain have been detected in MDD and more recently attempts have been made to apply these findings to clinical practice. In this review, we provide an updated summary of the progress in translational application of psychoradiological findings in MDD with a specified focus on potential clinical usage. The foreseeable clinical applications for different MRI modalities were introduced according to their role in disorder classification, subtyping, and prediction. While evidence of cerebral structural and functional changes associated with MDD classification and subtyping was heterogeneous and/or sparse, the ACC and hippocampus have been consistently suggested to be important biomarkers in predicting treatment selection and treatment response. These findings underlined the potential utility of brain biomarkers for clinical practice.

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Acknowledgments

This study was supported by the National Natural Science Foundation (Nos. 81171488, 81671669, 81621003, 81820108018, and 81801681), Program for Scholars and Innovative Research Team in University (PCSIRT, No. IRT16R52) of China.

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Authors and Affiliations

  1. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, China

    Ziqi Chen, Xiaoqi Huang & Qiyong Gong

  2. Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, 610041, China

    Xiaoqi Huang & Qiyong Gong

  3. Functional and Molecular Imaging Key Laboratory of Sichuan Province, Chengdu, 610041, China

    Xiaoqi Huang & Qiyong Gong

  4. Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA

    Bharat B. Biswal

  5. The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, 610054, China

    Bharat B. Biswal

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  1. Ziqi Chen
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  2. Xiaoqi Huang
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  3. Qiyong Gong
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  4. Bharat B. Biswal
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Correspondence to Xiaoqi Huang or Qiyong Gong.

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Ziqi Chen, Xiaoqi Huang, Qiyong Gong, and Bharat B. Biswal declare that they have no financial conflicts of interest. This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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Chen, Z., Huang, X., Gong, Q. et al. Translational application of neuroimaging in major depressive disorder: a review of psychoradiological studies. Front. Med. 15, 528–540 (2021). https://doi.org/10.1007/s11684-020-0798-1

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  • DOI: https://doi.org/10.1007/s11684-020-0798-1

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