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Chinese Medicine as Supporting Therapy for Psoriasis: Past, Present, and Future

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Abstract

Psoriasis is a chronic skin disease and an important health concern. Western medicine and therapies are the main treatment strategies for psoriasis vulgaris (PV); however, the overall prognosis of patients with PV is still poor. Therefore, PV prevention is especially crucial. Chinese medicine (CM) has a long history of treating psoriasis, and it has unique wisdom in different cognitive angles and treatment modes from modern medicine. In this review, we first summarized the herbs and ancient CM formulas that have therapeutic effects on PV. Second, the research status and obstacles to the current development of CM in modern medicine were reviewed. Finally, the future of CM in the context of precision medicine and integrated medicine was discussed. After a detailed reading of the abundant literature, we believe that CM, through thousands of years of continuous development and clinical practice, has achieved high effectiveness and safety for PV treatment, despite its surrounding controversy. Moreover, precise analyses and systematic research methods have provided new approaches for the modernization of CM in the future. The treatment of PV with CM is worth popularizing, and we hope it can benefit more patients.

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References

  1. Boehncke WH. Systemic inflammation and cardiovascular comorbidity in psoriasis patients: causes and consequences. Front Immunol 2018;9:579.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Rendon A, Schakel K. Psoriasis pathogenesis and treatment. Int J Mol Sci 2019;20:1475.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Boehncke WH. Etiology and pathogenesis of psoriasis. Rheum Dis Clin North Am 2015;41:665–675.

    Article  PubMed  Google Scholar 

  4. Xie ZY, Bai YP, Yang DQ. Associativity study of TCM constitution and differentiation of signs and symptoms for syndrome classification in psoriasis patient. China J Tradit Chin Med (Chin) 2009;24:823–825.

    Google Scholar 

  5. Salahadeen E, Torp-Pedersen C, Gislason G, et al. Nationwide population-based study of cause-specific death rates in patients with psoriasis. J Eur Acad Dermatol Venereol 2015;29:1002–1005.

    Article  CAS  PubMed  Google Scholar 

  6. Oliveira Mde F, Rocha Bde O, Duarte GV. Psoriasis: classical and emerging comorbidities. An Bras Dermatol 2015;90:9–20.

    Article  PubMed  Google Scholar 

  7. Pang CK, Gao TT. Meta analysis on risk factors of induced psoriasis among Chinese. Chin J Lepr Skin Dis (Chin) 2013;29:235–238.

    Google Scholar 

  8. Wang K, Zeng JQ, Wang XR, et al. Clinic treatment progress of psoriasis. Med Recap (Chin) 2017;23:4659–4664,4670.

    Google Scholar 

  9. Lu L, Chen J. Research progress in the treatment of psoriasis. Hebei Med J (Chin) 2017;39:3643–3647.

    Google Scholar 

  10. Lu C, Deng J, Li L, et al. Application of metabolomics on diagnosis and treatment of patients with psoriasis in traditional Chinese medicine. Biochim Biophys Acta 2014;1844:280–288.

    Article  CAS  PubMed  Google Scholar 

  11. Dai D, Wu HR, He CY, et al. Evidence and potential mechanisms of traditional Chinese medicine for the treatment of psoriasis vulgaris: a systematic review and meta-analysis. J Dermatolog Treat 2020;9:1–11.

    Google Scholar 

  12. Wang D, Lu C, Yu J, et al. Chinese medicine for psoriasis vulgaris based on syndrome pattern: a network pharmacological study. Evid Based Complement Alternat Med 2020;28:1–16.

    Google Scholar 

  13. Aldona P, Joanna B, Jacob D, et al. Deleterious effects of traditional Chinese medicine preparations on the course of psoriasis—a case report. Ann Agric Environ Med 2013;20:816–818.

    Google Scholar 

  14. Zeng QH, Hao PS. Treatment of psoriasis vulgaris according to priorities of “root and tip”. J Chengdu Univ Tradit Chin Med (Chin) 2021;44:66–69.

    Google Scholar 

  15. Wang DY, Zhang Y, Shi ZC. Discussion on treatment of psoriasis based on pathogenesis of heat toxin, blood dryness, blood stasis and blood deficiency. J Guangzhou Univ Tradit Chin Med (Chin) 2020;37:1391–1394.

    Google Scholar 

  16. Sun L, Li T, Zhou D, et al. Efficacy and safety of Liangxue Jiedu decoction for the treatment of progressive psoriasis vulgaris: a multicenter, randomized, controlled study. J Tradit Chin Med (Chin) 2020;40:296–304.

    Google Scholar 

  17. Song CL, Yang CX, Meng SW, et al. Deciphering the mechanism of Fang-Ji-Di-Huang-decoction in ameliorating psoriasis-like skin inflammation via the inhibition of IL-23/Th17 cell axis. J Ethnopharmacol 2021;281:114571.

    Article  CAS  PubMed  Google Scholar 

  18. Jin X, Xu H, Huang C, et al. A traditional Chinese medicine formula Danshen Baibixiao ameliorates imiquimod-induced psoriasis-like inflammation in mice. Front Pharmacol 2021;12:749626.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Dai YJ, Li YY, Zeng HM, et al. Effect of Yinxieling Decoction on PASI, TNF-α and IL-8 in patients with psoriasis vulgaris. Asian Pac J Trop Med 2014;7:668–670.

    Article  PubMed  Google Scholar 

  20. Jia J, Mo X, Liu J, et al. Mechanism of Danshensu-induced inhibition of abnormal epidermal proliferation in psoriasis. Eur J Pharmacol 2020;868:172881.

    Article  CAS  PubMed  Google Scholar 

  21. Chiang CC, Cheng WJ, Lin CY, et al. Kan-Lu-Hsiao-Tu-Tan, a traditional Chinese medicine formula, inhibits human neutrophil activation and ameliorates imiquimod-induced psoriasis-like skin inflammation. J Ethnopharmacol 2020;246:112246.

    Article  CAS  PubMed  Google Scholar 

  22. Wang L, Tao Y, Deng S, et al. Effectiveness comparisons of traditional Chinese medicine for psoriasis: a bayesian network meta-analysis. Medicine 2019;98:e17055.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Su Y, Qin W, Wu L, et al. A review of Chinese medicine for the treatment of psoriasis: principles, methods and analysis. Chin Med (Chin) 2021;16:138.

    Article  Google Scholar 

  24. Zhao R, Wu X, Bi XY, et al. Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury. Neural Regen Res 2022;17:1080–1087.

    Article  CAS  PubMed  Google Scholar 

  25. Niu B, Wei S, Sun J, et al. Deciphering the molecular mechanism of tetrandrine in inhibiting hepatocellular carcinoma and increasing sorafenib sensitivity by combining network pharmacology and experimental evaluation. Pharm Biol 2022;60:75–86.

    Article  CAS  PubMed  Google Scholar 

  26. Zhang YB, Wang BT, Xu P, et al. Integrated chemical molecular docking with network pharmacology to study the molecular mechanism of Jianpi Yiqi Busui method for treating myasthenia gravis. Chin J Anal Chem (Chin) 2022;50:1–12.

    Article  Google Scholar 

  27. Wei WC, Zhang QC, Qiu MY. Thoughts on the predicament and way out of the development of traditional Chinese medicine. Chin J Tradit Chin Med (Chin) 2021;36:6979–6982.

    Google Scholar 

  28. Wang JB, Cui HR, Bai ZF, et al. Precision medicine-oriented safety assessment strategy for traditional Chinese medicines: disease-syndrome-based toxicology. Acta Pharm Sinica (Chin) 2016;51:1681–1688.

    Google Scholar 

  29. Branisteanu DE, Pirvulescu RA, Spinu AE, et al. Metabolic comorbidities of psoriasis (review). Exp Ther Med 2022;23:179.

    Article  CAS  PubMed  Google Scholar 

  30. Cho SI, Kim YE, Jo SJ. Association of metabolic comorbidities with pediatric psoriasis: a systematic review and meta-analysis. Ann Dermatol 2021;33:203–213.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Mastorino L, Roccuzzo G, Dapavo P, et al. Patients with psoriasis resistant to multiple biologic therapies: characteristics and definition of a difficult-to-treat population. Br J Dermatol 2022

  32. Xiang XC, Tu CY, Li QY, et al. Oxymatrine ameliorates imiquimod-induced psoriasis pruritus and inflammation through inhibiting heat shock protein 90 and heat shock protein 60 expression in keratinocytes. Toxicol Appl Pharmacol 2020;405:115209.

    Article  CAS  PubMed  Google Scholar 

  33. Wang S, Zhu L, Xu Y, et al. Salvianolic acid B ameliorates psoriatic changes in imiquimod-induced psoriasis on BALB/c mice by inhibiting inflammatory and keratin markers via altering phosphatidylinositol-3-kinase/protein kinase B signaling pathway. Korean J Physiol Pharmacol 2020;24:213–221.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Shi Q, He Q, Chen W, et al. Ginsenoside Rg1 abolish imiquimod-induced psoriasis-like dermatitis in BALB/c mice via downregulating NF-κB signaling pathway. J Food Biochem 2019;43:e13032.

    Article  PubMed  Google Scholar 

  35. Lv H, Liu X, Chen W, et al. Yangxue Jiedu Fang ameliorates psoriasis by regulating vascular regression via survivin/PI3K/Akt pathway. J Immunol Res 2021;2021:4678087.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Nguyen LTH, Ahn SH, Nguyen UT, et al. Dang-Gui-Liu-Huang Tang a traditional herbal formula, ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by inhibiting IL-22 production. Phytomedicine 2018;47:48–57.

    Article  PubMed  Google Scholar 

  37. Ma Q, Pan J, Han Y. Overview of research on classification, treatment and prescription selection of psoriasis. Henan J Chin Med (Chin) 1994;1:35–38.

    Google Scholar 

  38. Yu C, Fan X, Li Z, et al. Efficacy and safety of total glucosides of paeony combined with acitretin in the treatment of moderate-to-severe plaque psoriasis: a doubleblind, randomised, placebo-controlled trial. Eur J Dermatol 2017;27:150–154.

    Article  CAS  PubMed  Google Scholar 

  39. Zhao J, Di T, Wang Y, et al. Multi-glycoside of Tripterygium wilfordii Hook. f. ameliorates imiquimod-induced skin lesions through a STAT3-dependent mechanism involving the inhibition of Th17-mediated inflammatory responses. Int J Mol Med 2016;38:747–757.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Yu GH, Li ZP. Clinical study on Tufuling tang combined with compound qingdai ointment for psoriasis vulgaris. New Chin Med (Chin) 2021;53:127–130.

    CAS  Google Scholar 

  41. Soliman MM. Depressive, anxiety, stress, and insomnia symptoms in patients with psoriasis: a cross-sectional study. Postepy Dermatol Alergol 2021;38:510–519.

    Article  PubMed  Google Scholar 

  42. Wu YS, Zhang B, Yuan JN, et al. The data mining analysis of the Chinese medicine and disease of the contemporary medical records on psoriasis based on association rules. Lishizhen Med Mater Med Res (Chin) 2012;23:2890–2892.

    Google Scholar 

  43. Zhang Q, Wang YM, Xie YH, et al. Clinical observation of Danggui Niantong Decoction in treating psoriatic arthritis with damp-heat arthritis. Beijing J Tradit Chin Med (Chin) 2011;30:246–248.

    Google Scholar 

  44. Wu XY, Wang XH, Li YH. Efficacy of Shentong Zhuyu Decoction combined with Western medicine in patients with blood stasis of psoriatic arthritis. Intern Med (Chin) 2017;12:480–483.

    Google Scholar 

  45. Li FS, Weng JK. Demystifying traditional herbal medicine with modern approach. Nat Plants 2017;3:17109.

    Article  PubMed  Google Scholar 

  46. Deng S, May BH, Zhang AL, et al. Topical herbal formulae in the management of psoriasis: systematic review with meta-analysis of clinical studies and investigation of the pharmacological actions of the main herbs. Phytother Res 2014;28:480–497.

    Article  PubMed  Google Scholar 

  47. Norooznezhad AH, Norooznezhad F. Cannabinoids: possible agents for treatment of psoriasis via suppression of angiogenesis and inflammation. Med Hypotheses 2017;99:15–18.

    Article  CAS  PubMed  Google Scholar 

  48. Luengas-Martinez A, Paus R, Young HS. A novel personalised treatment approach for psoriasis: anti-VEGF-A therapy. Br J Dermatol 2021;186:782–791.

    Article  Google Scholar 

  49. Li J, Hou H, Zhou L, et al. Increased angiogenesis and migration of dermal microvascular endothelial cells from patients with psoriasis. Exp Dermatol 2021;30:973–981.

    Article  PubMed  Google Scholar 

  50. Lu Y, Yang Y, Zhang J, et al. Anti-angiogenic efficacy of PSORI-CM02 and the associated mechanism in psoriasis in vitro and in vivo. Front Immunol 2021;12:649591.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Chang HN, Huang ST, Yeh YC, et al. Indigo naturalis and its component tryptanthrin exert anti-angiogenic effect by arresting cell cycle and inhibiting Akt and FAK signaling in human vascular endothelial cells. J Ethnopharmacol 2015;174:474–481.

    Article  CAS  PubMed  Google Scholar 

  52. De Oliveira LG, Figueiredo LA, Fernandes-Cunha GM, et al. Methotrexate locally released from poly(e-caprolactone) implants: inhibition of the inflammatory angiogenesis response in a murine sponge model and the absence of systemic toxicity. J Pharm Sci 2015;104:3731–3742.

    Article  PubMed  Google Scholar 

  53. Xu Y, Xu X, Gao X, et al. Shikonin suppresses IL-17-induced VEGF expression via blockage of JAK2/STAT3 pathway. Int Immunopharmacol 2014;19:327–333.

    Article  CAS  PubMed  Google Scholar 

  54. Valdimarsson H, Bake BS, Jonsdotdr I, et al. Psoriasis: a disease of abnormal keratinocyte proliferation induced by T lymphocytes. Immunol Today 1986;7:256–259.

    Article  CAS  PubMed  Google Scholar 

  55. Jie XR, Liu X, Wang Y, et al. Effect of Liangxue Jiedu Decoction and its dismantled formulae on keratinocyte proliferation induced by activated T lymphocytes. China J Tradit Chin Med (Chin) 2013;38:3953–3956.

    Google Scholar 

  56. Yu JH, Zhao RZ, Lv CJ. Anti-psoriatic effects of optimized Yinxieling Formula on psoriasis-like model of guinea pigs and cell model of lipopolysaccharide-stimulated HaCaT keratinocyte. China J Tradit Chin Med (Chin) 2013;28:1531–1534.

    CAS  Google Scholar 

  57. Wang JW, Li M, Zhuai RJ, et al. Effect of Huoxue Jiedu Recipe medicated serum on proliferation and cell cycle status of keratinocytes of psoriasis. J Tradit Chin Med (Chin) 2010;51:740–742.

    CAS  Google Scholar 

  58. Huang Q, Qu X, Wu Q. Experimental study of three kinds of Chinese Herbs in treating psoriasis. China J Inf Tradit Chin Med (Chin) 2008;167:30–31.

    Google Scholar 

  59. Wang D, Cheng S, Zou G, et al. Paeoniflorin inhibits proliferation and migration of psoriatic keratinocytes via the lncRNA NEAT1/miR-3194-5p/Galectin-7 axis. Anticancer Drugs 2022;33:e423–e433.

    Article  CAS  PubMed  Google Scholar 

  60. Mao J, Ma X, Zhu J, et al. Ginsenoside Rg1 ameliorates psoriasis-like skin lesions by suppressing proliferation and NLRP3 inflammasomes in keratinocytes. J Food Biochem 2022:e14053.

  61. Li X, Xie X, Zhang L, et al. Hesperidin inhibits keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis via the IRS-1/ERK1/2 pathway. Life Sci 2019;219:311–321.

    Article  CAS  PubMed  Google Scholar 

  62. Wang WQ, Zeng YB, Zhang T, et al. Effects of curcumin on proliferation and apoptosis of HaCaT cells and its mechanism. Shandong Med J (Chin) 2019;59:33–36.

    Google Scholar 

  63. Sato Y, Ogawa E, Okuyama R. Role of innate immune cells in psoriasis. Int J Mol Sci 2020;21:6604.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Priyadarssini M, Divya Priya D, Indhumathi S, et al. Immunophenotyping of T cells in the peripheral circulation in psoriasis. Br J Biomed Sci 2016;73:174–179.

    Article  CAS  PubMed  Google Scholar 

  65. Littman DR, Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Cell 2010;140:845–858.

    Article  CAS  PubMed  Google Scholar 

  66. Lin L, An YP, Wang SS, et al. Follicular helper T cells, psoriasis, and Chinese medicine intervention: a review. Chin J Exp Tradit Medi Form (Chin) 2022;28:246–253.

    Google Scholar 

  67. Ma AL, Yang YY, Wang QY, et al. Anti-inflammatory effects of oxymatrine on rheumatoid arthritis in rats via regulating the imbalance between Treg and Th17 cells. Mol Med Rep 2017;15:3615–3622.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Wang G, Yang YY, Jiang H, et al. Effect of oxymatrine on immunological function of Tfh in BALB/c mice. J Ningxia Med Univ (Chin) 2018;40:33–36.

    Google Scholar 

  69. Li BB, He SC, Liu R, et al. Total glucosides of paeony attenuates animal psoriasis induced inflammatory response through inhibiting STAT1 and STAT3 phosphorylation. J Ethnopharmacol 2019;243:112121.

    Article  CAS  PubMed  Google Scholar 

  70. Madonna S, Scarponi C, Pallotta S, et al. Anti-apoptotic effects of sup-pressor of cytokine signaling 3 and 1 in psoriasis. Cell Death Dis 2012;3:e334.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Bianchi L, Farrace MG, Nini G, et al. Abnormal Bcl-2 and “tissue” transglutaminase expression in psoriatic skin. J Invest Dermatol 1994;103:829–833.

    Article  CAS  PubMed  Google Scholar 

  72. Chen H, Lu C, Liu H, et al. Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-kappaB pathway. Int Immunopharmacol 2017;48:110–117.

    Article  CAS  PubMed  Google Scholar 

  73. Zeng DG, Mo YS, Liu RF, et al. Effect of aloe emodin on proliferation and apoptosis of HaCaT cells. Chin Pharm (Chin) 2014;23:41–42.

    CAS  Google Scholar 

  74. Lv RH, Feng FX, Feng Z, et al. Esculentoside reduces expression of Th17 cell-related cytokines in psoriasislike mouse model. Chin J Cell Mol Immunol (Chin) 2019;35:595–600.

    Google Scholar 

  75. Wang JF, Zhang HY, Liu TF, et al. Baicalin inhibits the activity of keratinocytes in pssoriasis by activating Notch signaling pathway. Chin J Cell Mol Immunol (Chin) 2019;35:441–446.

    CAS  Google Scholar 

  76. Mou KH, Zhou Y, Han D, et al. Regulation of Bcl-2/Bax and Fas/FasL by matrine in HaCaT cells. Chin J Lepr Skin Dis (Chin) 2014;30:387–389.

    Google Scholar 

  77. Thatikonda S, Pooladanda V, Sigalapalli DK, et al. Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation. Cell Death Dis 2020;11:21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Hu LX, Liu Q. Effect and mechanism of Qingxuedu Capsule on psoriasis vulgaris in mice. Pharm Clin Chin Mater Med (Chin) 2021;37:92–97.

    Google Scholar 

  79. Zhang XT. Study on caspase-3 and apoptosis. Med Recap (Chin) 2002;11:621–623.

    Google Scholar 

  80. Ha ES, Lee EO, Yoon TJ, et al. Methylene chloride fraction of Spatholobi Caulis induces apoptosis via caspase dependent pathway in U937 cells. Biol Pharm Bull 2004;27:1348–1352.

    Article  CAS  PubMed  Google Scholar 

  81. Kjaer TN, Thorsen K, Jessen N, et al. Resveratrol ameliorates imiquimod-induced psoriasis-like skin inflammation in mice. PLoS One 2015;10:e0126599.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Lv J, Zhou D, Wang Y, et al. Effects of luteolin on treatment of psoriasis by repressing HSP90. Int Immunopharmacol 2020;79:106070.

    Article  CAS  PubMed  Google Scholar 

  83. Lan SH, Ye J, Zou X, et al. Effect of Tripterygium wilfordii on serum levels of IL-6, IL-17, and IL-23 in patients with psoriasis vulgaris. J Clin Dermatol (Chin) 2017;46:877–879.

    Google Scholar 

  84. Li XQ, Chen Y, Dai GC, et al. Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. J Ethnopharmacol 2021; 272:113934.

    Article  CAS  PubMed  Google Scholar 

  85. Di TT, Ruan ZT, Zhao JX, et al. Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via Jak3/Stat3 signaling pathway. Int Immunopharmacol 2016;32:32–38.

    Article  CAS  PubMed  Google Scholar 

  86. Schiraldi M, Raucci A, Munoz LM, et al. HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4. J Exp Med 2012;209:551–563.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Hu MM, Liu QF, Zang XH, et al. Effect of rutaecarpine on imiquimod (IMQ)-induced psoriasis-like mouse model. Chin J Dermatovenereol (Chin) 2020;34:1366–1371.

    Google Scholar 

  88. Park EJ, Pezzuto JM. The pharmacology of resveratrol in animals and humans. Biochim Biophys Acta 2015;1852:1071–1113.

    Article  CAS  PubMed  Google Scholar 

  89. Liu TH, Liu DH, Wang J, et al. Effects of matrine, oxymatrine and sophoridine on activity and TNF-α secretion of macrophage RAW264.7. China J Inf Tradit Chin Med (Chin) 2010;17:31–33.

    Google Scholar 

  90. Liu TH, Liu DF, Wang XJ, et al. Study of inhibitory effects of aconitine and mesaconitine on TNF-α secretion CD91 and CD 13 expression in RAW 264.7 macrophages. Med J Nat Defend For Southwest Chin (Chin) 2009;19:1168–1171, 1350.

    CAS  Google Scholar 

  91. Li YL, Du ZY, Li PH, et al. Aromatic-turmerone ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice. Int Immunopharmacol 2018;64:319–325.

    Article  CAS  PubMed  Google Scholar 

  92. Wang HF, Liu JL, Yang YJ, et al. Hydroxy-safflower yellow A inhibits the TNFR1-mediated classical NF-κB pathway by inducing shedding of TNFR1. Phytother Res 2016;30:790–796.

    Article  CAS  PubMed  Google Scholar 

  93. Zheng Q, Jiang W, Sun X, et al. Total glucosides of paeony for the treatment of psoriasis: a systematic review and meta-analysis of randomized controlled trials. Phytomedicine 2019;62:152940.

    Article  CAS  PubMed  Google Scholar 

  94. Kanayama Y, Torii K, Ikumi K, et al. Bath psoralen plus UVA therapy suppresses keratinocyte-derived chemokines in pathogenetically relevant cells. JID Innov 2021;1:100027.

    Article  PubMed  PubMed Central  Google Scholar 

  95. Ru Y, Li H, Zhang R, et al. Role of keratinocytes and immune cells in the anti-inflammatory effects of Tripterygium wilfordii Hook. f. in a murine model of psoriasis. Phytomedicine 2020;77:153299.

    Article  CAS  PubMed  Google Scholar 

  96. Chi Q, Wang L, Zhang Q. Therapeutic effect of Danhong Injection on diabetic patients with cerebral infarction and its influence on vascular endothelial function and hemodynamics. Pak J Pharm Sci 2021;34:2065–2069.

    CAS  PubMed  Google Scholar 

  97. Liu YR, Zhan SY, Zheng BH, et al. Advance on pharmacokinetics study of traditional Chinese medicine injections in recent ten years. China J Tradit Chin Med (Chin) 2021;46:1752–1762.

    Google Scholar 

  98. Wang ZW. A case of death caused by high-dose oral Tripterygium Hypoglaucum. Chin J Dermatovenereol (Chin) 1994;8:105.

    CAS  Google Scholar 

  99. Bagcchi S. Herbal medicines safety concerns in patients with cancer. Lancet Oncol 2016;17:e10.

    Article  PubMed  Google Scholar 

  100. Cen XN. On the cancellation of the medicinal standards of aristolochic acid-containing Chinese medicines. Chin Pharm (Chin) 2007;18:2321–2322.

    CAS  Google Scholar 

  101. Lu Y, Qi Y, Li L, et al. The gene expression analysis of peripheral blood monocytes from psoriasis vulgaris patients with different traditional Chinese medicine syndromes. Front Pharmacol 2021;12:759741.

    Article  CAS  PubMed  Google Scholar 

  102. Frontiers Production O. Erratum: Chinese herbal medicine for psoriasis: evidence from 11 high-quality randomized controlled trials. Front Pharmacol 2021;12:672760.

    Article  Google Scholar 

  103. Ma T, Jiang WC, Li X, et al. Effects of Chinese formula Jueyin Granules on psoriasis in an animal model. Evid Based Complement Alternat Med 2014;2014:512562.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Bao J, Ding RB, Liang Y, et al. Differences in chemical component and anticancer activity of green and ripe forsythiae fructus. Am J Chin Med 2017;45:1513–1536.

    Article  CAS  PubMed  Google Scholar 

  105. Xu XT, Tang HH, Sang Z. Development status and prospects of international standardization of medical devices of traditional Chinese medicine. Pharmacol Res 2021;167:105485.

    Article  Google Scholar 

  106. Chen HH, Tsai SL, You WR, et al. Current status and outlook on the development of traditional Chinese medicine in Taiwan. J Formos Med Assoc 2018;117:544–546.

    Article  PubMed  Google Scholar 

  107. Yuwen Y, Han XJ, Wang LY, et al. Thinking on methods for formulating development strategy of traditional Chinese medicine standardization. J Integr Med (Chin) 2011;9:483–486.

    Article  Google Scholar 

  108. Chen R, Snyder M. Promise of personalized omics to precision medicine. Wiley Interdiscip Rev Syst Biol Med 2013;5:73–82.

    Article  PubMed  Google Scholar 

  109. Elh L, Wong VK, Jiang ZH. Integrated network-based medicine: the role of traditional Chinese medicine in developing a new generation of medicine. Science 2014;346:1569.

    Google Scholar 

  110. Tang HC, Huang HJ, Lee CC, et al. Network pharmacology-based approach of novel traditional Chinese medicine formula for treatment of acute skin inflammation in silico. Comput Biol Chem 2017;71:70–81.

    Article  CAS  PubMed  Google Scholar 

  111. Azmi AS. Adopting network pharmacology for cancer drug discovery. Curr Drug Discov Technol 2013;10:95–105.

    Article  CAS  PubMed  Google Scholar 

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Yang XY was mainly responsible for the writing of manuscripts; Cai WL was responsible for the design of the thesis framework and the retrieval and collation of literature. Yang XY and Cai WL made equal contributions to this work. Guo CL and Chen QH guided the manuscript.

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Correspondence to Qi-hua Chen.

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Supported by the General Project of the Hunan Provincial Natural Science Foundation (No. 2020JJ4068) and the Key Projects of the Hunan Provincial Traditional Chinese Medicine Research Program (No. 2021001)

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Yang, Xy., Cai, Wl., Guo, Cl. et al. Chinese Medicine as Supporting Therapy for Psoriasis: Past, Present, and Future. Chin. J. Integr. Med. 29, 280–288 (2023). https://doi.org/10.1007/s11655-022-3683-8

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