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Data Availability
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
References
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The official site of Surveilance, Epidemiology, and End Results (SEER) database. The link available at https://seer.cancer.gov/.
Kurokawa Y, Takeuchi H, Doki Y, et al. Mapping of Lymph Node Metastasis From Esophagogastric Junction Tumors: A Prospective Nationwide Multicenter Study. Ann Surg. 2021;274(1):120-127. https://doi.org/10.1097/SLA.0000000000003499.
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Acknowledgements
We thank all colleagues who collected patients’ data and devoted into medical care. We also thank all the family members (Chungui Ke et.at) who are supporting us. We hope more accurate staging system maybe helpful for these special patients.
Funding
This study was supported by Fujian Research and Training Grants for Young and Middle-aged Leaders in Healthcare for Jun Lu (No.[2023] 26).
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Authors and Affiliations
Contributions
Conception/Design: Dong Wu, Hui Wang, Jun Lu, Bin-bin Xu.
Collection and/or assembly of data: Dong Wu, Hui Wang, Jun Lu, Bin-bin Xu, Zhen Xue, Jia Lin.
Data analysis and interpretation: Dong Wu, Hui Wang, Jia Lin, Jun Lu, Zhen Xue, Bin-bin Xu, Liang-liang Xu.
Manuscript writing: Dong Wu, Hui Wang, Jun Lu, Bin-bin Xu, Jia Lin.
All authors read and approved the final manuscript.
Corresponding authors
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Human Rights Statement and Informed Consent
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.
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This article doesn’t report an individual participant's data in any form.
Conflicts of Interest
The authors declare that they have no financial, consultant, or institutional conflict of interest.
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Dong Wu, Hui Wang, Bin-Bin Xu, and Jia Lin contributed equally to this work and should be considered co-first author.
Supplementary Information
Below is the link to the electronic supplementary material.
11605_2023_5730_MOESM3_ESM.pdf
Supplemental Fig. 3 X-tile analysis for calculating the cut-off point of LODDS (LODDS: log odds of positive lymph node) (PDF 161 KB)
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Supplemental Fig. 5 Cox adjusted survival curves of OS (A) and CSS (B) in comparison of Siewert type II AEG patients with <13 retrieved LNs and ≥13 retrieved LNs (PDF 1080 KB)
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Supplemental Fig. 6 The interactive correlation among N, LNR, LODDS and NLN. (LNR: lymph node ratio; LODDS: log odds of positive lymph node; NLN: negative lymph node) (PDF 805 KB)
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Supplemental Fig. 7 Kaplan-Meier (K-M) survival curves of OS and CSS according to pN stages in subgroups. In retrieved LNs≥13, K-M survival curve of OS (A) and CSS (B) according to esophagus cancer pN stages. In retrieved LNs ≥13, K-M survival curve of OS (C) and CSS (D) according to esophagus cancer pN stages. In retrieved LNs<13, K-M survival curve of OS (E) and CSS (F) according to pN stages (not enough for N3b) (PDF 14762 KB)
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Wu, D., Wang, H., Xu, BB. et al. Novel Staging Schemes for Siewert Type II Esophagogastric Junction Adenocarcinoma: A Real-World Data Cohort Study from SEER Database. J Gastrointest Surg 27, 2592–2596 (2023). https://doi.org/10.1007/s11605-023-05730-9
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DOI: https://doi.org/10.1007/s11605-023-05730-9