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A phenomenological model of pulsatile blood pressure-affected degradation of polylactic acid (PLA) vascular stent

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Abstract

The stent implantation may alter the post-operative patient’s blood pressure, and bioresorbable vascular stents (BVS) as a candidate to treat vascular diseases, its degradation is affected by mechanical stress, thus, the altered pressure representing varying stress level will result in different degradation behaviors of the BVS. This paper first proposed a novel stress-regulated PLA degradation model that included swelling factor, and then the degradation evolutions of a PLA BVS within 180 days under normal and high blood pressures were simulated by finite element method, and more four degradation indexes were defined to study the effects of the two blood pressures on the degradation of the PLA BVS. The results showed that the high pressure weakly accelerated the degradation of the PLA BVS with respect to the normal pressure by examining the four indexes, e.g., the residual stent volume \({v}_{r}(t)\) decreased to 0.72 and 0.69, respectively for the normal and high pressures at day 180. The current finding provided a theoretical understanding of the PLA BVS degradation, and hinted that the PLA BVS may not need to be elaborately selected in clinical practices for treating hypertensive patients.

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References

  1. Amirjani A, Yousefi M, Cheshmaroo M (2014) Parametrical optimization of stent design; a numerical-based approach. Comput Mater Sci 90:210–220. https://doi.org/10.1016/j.commatsci.2014.04.002

    Article  CAS  Google Scholar 

  2. Hermawan H, Dube D, Mantovani D (2010) Developments in metallic biodegradable stents. Acta Biomater 6(5):1693–1697. https://doi.org/10.1016/j.actbio.2009.10.006

    Article  CAS  PubMed  Google Scholar 

  3. Li N, Zhang H, Ouyang H (2009) Shape optimization of coronary artery stent based on a parametric model. Finite Elem Anal Des 45(6–7):468–475. https://doi.org/10.1016/j.finel.2009.01.001

    Article  Google Scholar 

  4. Boland EL, Shine R, Kelly N et al (2016) A review of material degradation modelling for the analysis and design of bioabsorbable stents. Ann Biomed Eng 44(2):341–356. https://doi.org/10.1007/s10439-015-1413-5

    Article  PubMed  Google Scholar 

  5. Singh R, Bathaei MJ, Istif E et al (2020) A review of bioresorbable implantable medical devices: materials, fabrication, and implementation. Adv Healthc Mater 9(18):e2000790. https://doi.org/10.1002/adhm.202000790

    Article  CAS  PubMed  Google Scholar 

  6. Park H, Hong YJ, Cho JY et al (2017) Blood pressure targets and clinical outcomes in patients with acute myocardial infarction. Korean Circ J 47(4):446–454. https://doi.org/10.4070/kcj.2017.0008

    Article  PubMed  PubMed Central  Google Scholar 

  7. Tsai TY, Leu HB, Hsu PF et al (2022) Association between visit-to-visit blood pressure variability and adverse events in coronary artery disease patients after coronary intervention. J Clin Hypertens 24(10):1327–1338. https://doi.org/10.1111/jch.14565

    Article  Google Scholar 

  8. Rosendorff C, Lackland DT, Allison M et al (2015) Treatment of hypertension in patients with coronary artery disease: a scientific statement from the American Heart Association, American College of Cardiology, and American Society of Hypertension. Circulation 131(19):e435-470. https://doi.org/10.1161/CIR.0000000000000207

    Article  PubMed  PubMed Central  Google Scholar 

  9. Lee CW, Lee JK, Choi YJ et al (2022) Blood pressure and mortality after percutaneous coronary intervention: a population-based cohort study. Sci Rep 12(1):2768. https://doi.org/10.1038/s41598-022-06627-4

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Clark D, Nicholls SJ, St John J et al (2019) Visit-to-visit blood pressure variability, coronary atheroma progression, and clinical outcomes. JAMA Cardiol 4(5):437–443. https://doi.org/10.1001/jamacardio.2019.0751

    Article  PubMed  PubMed Central  Google Scholar 

  11. Chen H, Shi Q, Shui H et al (2021) Degradation of 3D-printed porous polylactic acid scaffolds under mechanical stimulus. Front Bioeng Biotechnol 9:691834. https://doi.org/10.3389/fbioe.2021.691834

    Article  PubMed  PubMed Central  Google Scholar 

  12. Shi Q, Chen Q, Pugno N et al (2018) Effect of rehabilitation exercise durations on the dynamic bone repair process by coupling polymer scaffold degradation and bone formation. Biomech Model Mechanobiol 17(3):763–775. https://doi.org/10.1007/s10237-017-0991-6

    Article  PubMed  Google Scholar 

  13. Shui H, Shi Q, Pugno NM et al (2019) Effect of mechanical stimulation on the degradation of poly(lactic acid) scaffolds with different designed structures. J Mech Behav Biomed Mater 96:324–333. https://doi.org/10.1016/j.jmbbm.2019.04.028

    Article  CAS  PubMed  Google Scholar 

  14. Li X, Chu C, Wei Y et al (2017) In vitro degradation kinetics of pure PLA and Mg/PLA composite: effects of immersion temperature and compression stress. Acta Biomater 48:468–478. https://doi.org/10.1016/j.actbio.2016.11.001

    Article  CAS  PubMed  Google Scholar 

  15. Wu Z, Wang L, Fan Y (2023) Effect of static tensile stress on enzymatic degradation of poly(glycerol sebacate). J Biomed Mater Res A. https://doi.org/10.1002/jbm.a.37550

    Article  PubMed  Google Scholar 

  16. Han XX, Pan JZ (2009) A model for simultaneous crystallisation and biodegradation of biodegradable polymers. Biomaterials 30(3):423–430. https://doi.org/10.1016/j.biomaterials.2008.10.001

    Article  CAS  PubMed  Google Scholar 

  17. Beyer MK, Clausen-Schaumann H (2005) Mechanochemistry: The mechanical activation of covalent bonds. Chem Rev 105(8):2921–2948. https://doi.org/10.1021/cr030697h

    Article  CAS  PubMed  Google Scholar 

  18. Gong Y, Zhou Q, Gao C et al (2007) In vitro and in vivo degradability and cytocompatibility of poly(l-lactic acid) scaffold fabricated by a gelatin particle leaching method. Acta Biomater 3(4):531–540. https://doi.org/10.1016/j.actbio.2006.12.008

    Article  CAS  PubMed  Google Scholar 

  19. Liu G, Zhang X, Wang D (2014) Tailoring crystallization: towards high-performance poly(lactic acid). Adv Mater 26(40):6905–6911. https://doi.org/10.1002/adma.201305413

    Article  CAS  PubMed  Google Scholar 

  20. Zolnik BS, Burgess DJ (2007) Effect of acidic pH on PLGA microsphere degradation and release. J Control Release 122(3):338–344. https://doi.org/10.1016/j.jconrel.2007.05.034

    Article  CAS  PubMed  Google Scholar 

  21. Bode C, Kranz H, Fivez A et al (2019) Often neglected: PLGA/PLA swelling orchestrates drug release: HME implants. J Control Release 306:97–107. https://doi.org/10.1016/j.jconrel.2019.05.039

    Article  CAS  PubMed  Google Scholar 

  22. Gopferich A, Langer R (1993) Modeling of polymer erosion. Macromolecules 26:4105–4112. https://doi.org/10.1021/ma00068a006

    Article  CAS  Google Scholar 

  23. Ebrahimi-Nozari T, Imani R, Haghbin-Nazarpak M et al (2023) Multimodal effects of asymmetric coating of coronary stents by electrospinning and electrophoretic deposition. Int J Pharm 630:122437. https://doi.org/10.1016/j.ijpharm.2022.122437

    Article  CAS  PubMed  Google Scholar 

  24. Iñiguez-Franco F, Auras R, Burgess G et al (2016) Concurrent solvent induced crystallization and hydrolytic degradation of PLA by water-ethanol solutions. Polymer 99:315–323. https://doi.org/10.1016/j.polymer.2016.07.018

    Article  CAS  Google Scholar 

  25. Bose SM, Git Y (2004) Mathematical modelling and computer simulation of linear polymer degradation: simple scissions. Macromol Theor Simul 13(5):453–473. https://doi.org/10.1002/mats.200300036

    Article  CAS  Google Scholar 

  26. Thombre AG, Himmelstein KJ (1985) A simultaneous transport-reaction model for controlled drug delivery from catalyzed bioerodible polymer matrices. AIChE J 31(5):759–766. https://doi.org/10.1002/aic.690310509

    Article  CAS  Google Scholar 

  27. Chen Y, Zhou S, Li Q (2011) Mathematical modeling of degradation for bulk-erosive polymers: applications in tissue engineering scaffolds and drug delivery systems. Acta Biomater 7(3):1140–1149. https://doi.org/10.1016/j.actbio.2010.09.038

    Article  CAS  PubMed  Google Scholar 

  28. Vieira AC, Vieira JC, Ferra JM et al (2011) Mechanical study of PLA-PCL fibers during in vitro degradation. J Mech Behav Biomed Mater 4(3):451–460. https://doi.org/10.1016/j.jmbbm.2010.12.006

    Article  CAS  PubMed  Google Scholar 

  29. Zhang H, Du T, Chen S et al (2022) Finite element analysis of the non-uniform degradation of biodegradable vascular stents. J Funct Biomater 13(3):152. https://doi.org/10.3390/jfb13030152

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Gao YM, Wang LZ, Gu XN et al (2018) A quantitative study on magnesium alloy stent biodegradation. J Biomech 74:98–105. https://doi.org/10.1016/j.jbiomech.2018.04.027

    Article  PubMed  Google Scholar 

  31. Resnick N, Yahav H, Shay-Salit A et al (2003) Fluid shear stress and the vascular endothelium: for better and for worse. Prog Biophys Molecul Biol 81(3):177–199. https://doi.org/10.1016/S0079-6107(02)00052-4

    Article  Google Scholar 

  32. Proikakis CS, Mamouzelos NJ, Tarantili PA et al (2006) Swelling and hydrolytic degradation of poly(d, l-lactic acid) in aqueous solutions. Polym Degrad Stab 91(3):614–619. https://doi.org/10.1016/j.polymdegradstab.2005.01.060

    Article  CAS  Google Scholar 

  33. David Chua SN, Mac Donald BJ, Hashmi MSJ (2003) Finite element simulation of stent and balloon interaction. J Mater Process Tech 143–144:591–597. https://doi.org/10.1016/s0924-0136(03)00435-7

    Article  Google Scholar 

  34. Grabow N, Schlun M, Sternberg K et al (2005) Mechanical properties of laser cut poly(L-lactide) micro-specimens: implications for stent design, manufacture, and sterilization. J Biomech Eng-T ASME 127(1):25–31. https://doi.org/10.1115/1.1835349

    Article  Google Scholar 

  35. Dumitru AC, Espinosa FM, Garcia R et al (2015) In situ nanomechanical characterization of the early stages of swelling and degradation of a biodegradable polymer. Nanoscale 7(12):5403–5410. https://doi.org/10.1039/c5nr00265f

    Article  CAS  PubMed  Google Scholar 

  36. Khalaj Amnieh S, Mashayekhi M, Shahnooshi E et al (2021) Biodegradable performance of PLA stents affected by geometrical parameters: the risk of fracture and fragment separation. J Biomech 122:110489. https://doi.org/10.1016/j.jbiomech.2021.110489

    Article  PubMed  Google Scholar 

  37. Guo M, Chu Z, Yao J et al (2016) The effects of tensile stress on degradation of biodegradable PLGA membranes: a quantitative study. Polym Degrad Stabil 124:95–100. https://doi.org/10.1016/j.polymdegradstab.2015.12.019

    Article  CAS  Google Scholar 

  38. Cui X, Peng K, Liu S et al (2019) A computational modelling of the mechanical performance of a bioabsorbable stent undergoing cyclic loading. Procedia Struct Integr 15:67–74. https://doi.org/10.1016/j.prostr.2019.07.013

    Article  Google Scholar 

  39. Lin S, Dong P, Zhou C et al (2020) Degradation modeling of poly-l-lactide acid (PLLA) bioresorbable vascular scaffold within a coronary artery. Nanotechnol Rev 9(1):1217–1226. https://doi.org/10.1515/ntrev-2020-0093

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Li Y, Chu Z, Li X et al (2017) The effect of mechanical loads on the degradation of aliphatic biodegradable polyesters. Regen Biomater 4(3):179–190. https://doi.org/10.1093/rb/rbx009

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Li X, Yu W, Han L et al (2019) Degradation behaviors of Mg alloy wires/PLA composite in the consistent and staged dynamic environments. Mater Sci Eng C Mater Biol Appl 103:109765. https://doi.org/10.1016/j.msec.2019.109765

    Article  CAS  PubMed  Google Scholar 

  42. Li X, Qi C, Han L et al (2017) Influence of dynamic compressive loading on the in vitro degradation behavior of pure PLA and Mg/PLA composite. Acta Biomater 64:269–278. https://doi.org/10.1016/j.actbio.2017.08.004

    Article  CAS  PubMed  Google Scholar 

  43. Liu L, Shi Q, Chen Q et al (2019) Mathematical modeling of bone in-growth into undegradable porous periodic scaffolds under mechanical stimulus. J Tissue Eng 10:2041731419827167. https://doi.org/10.1177/2041731419827167

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

The authors thank the School of Civil Engineering of Southeast University for the commercial software ABAQUS.

Funding

The research was supported by the National Natural Science Foundation of China (32171307, 12372307, 61821002, 12172089) and ARC (DP200103492).

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Authors and Affiliations

  1. Biomechanics Laboratory, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, People’s Republic of China

    Shicheng He, Qiang Chen & Zhiyong Li

  2. Jiangsu Key Laboratory of Artificial Functional Materials, College of Engineering and Applied Sciences, Nanjing University, Nanjing, 210023, People’s Republic of China

    Wanling Liu

  3. School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230601, People’s Republic of China

    Lingling Wei

  4. School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD4001, Australia

    Zhiyong Li

  5. Faculty of Sports Science, Ningbo University, Ningbo, 315211, People’s Republic of China

    Zhiyong Li

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He, S., Liu, W., Wei, L. et al. A phenomenological model of pulsatile blood pressure-affected degradation of polylactic acid (PLA) vascular stent. Med Biol Eng Comput 62, 1347–1359 (2024). https://doi.org/10.1007/s11517-023-02998-6

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  • DOI: https://doi.org/10.1007/s11517-023-02998-6

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