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Zooming on T cells in cancer

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References

  • Beltra, J.C., Manne, S., Abdel-Hakeem, M.S., Kurachi, M., Giles, J.R., Chen, Z., Casella, V., Ngiow, S.F., Khan, O., Huang, Y.J., et al. (2020). Developmental relationships of four exhausted CD8+ T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms. Immunity 52, 825–841.e8.

    Article  CAS  Google Scholar 

  • Galon, J., and Bruni, D. (2019). Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Nat Rev Drug Discov 18, 197–218.

    Article  CAS  Google Scholar 

  • Guo, X., Zhang, Y., Zheng, L., Zheng, C., Song, J., Zhang, Q., Kang, B., Liu, Z., Jin, L., Xing, R., et al. (2018). Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing. Nat Med 24, 978–985.

    Article  CAS  Google Scholar 

  • Jiang, Y., Li, Y., and Zhu, B. (2015). T-cell exhaustion in the tumor microenvironment. Cell Death Dis 6, e1792.

    Article  CAS  Google Scholar 

  • Lawrence, M.S., Stojanov, P., Polak, P., Kryukov, G.V., Cibulskis, K., Sivachenko, A., Carter, S.L., Stewart, C., Mermel, C.H., Roberts, S.A., et al. (2013). Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 499, 214–218.

    Article  CAS  Google Scholar 

  • Liu, X., Wang, Y., Lu, H., Li, J., Yan, X., Xiao, M., Hao, J., Alekseev, A., Khong, H., Chen, T., et al. (2019). Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction. Nature 567, 525–529.

    Article  CAS  Google Scholar 

  • Paley, M.A., Kroy, D.C., Odorizzi, P.M., Johnnidis, J.B., Dolfi, D.V., Barnett, B.E., Bikoff, E.K., Robertson, E.J., Lauer, G.M., Reiner, S.L., et al. (2012). Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science 338, 1220–1225.

    Article  CAS  Google Scholar 

  • Pauken, K.E., Sammons, M.A., Odorizzi, P.M., Manne, S., Godec, J., Khan, O., Drake, A.M., Chen, Z., Sen, D.R., Kurachi, M., et al. (2016). Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science 354, 1160–1165.

    Article  CAS  Google Scholar 

  • Philip, M., and Schietinger, A. (2022). CD8+ T cell differentiation and dysfunction in cancer. Nat Rev Immunol 22, 209–223.

    Article  CAS  Google Scholar 

  • Tirosh, I., Izar, B., Prakadan, S.M., Wadsworth II, M.H., Treacy, D., Trombetta, J.J., Rotem, A., Rodman, C., Lian, C., Murphy, G., et al. (2016). Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science 352, 189–196.

    Article  CAS  Google Scholar 

  • Utzschneider, D.T., Charmoy, M., Chennupati, V., Pousse, L., Ferreira, D. P., Calderon-Copete, S., Danilo, M., Alfei, F., Hofmann, M., Wieland, D., et al. (2016). T cell factor 1-expressing memory-like CD8+ T cells sustain the immune response to chronic viral infections. Immunity 45, 415–427.

    Article  CAS  Google Scholar 

  • Waldman, A.D., Fritz, J.M., and Lenardo, M.J. (2020). A guide to cancer immunotherapy: from T cell basic science to clinical practice. Nat Rev Immunol 20, 651–668.

    Article  CAS  Google Scholar 

  • Wherry, E.J. (2011). T cell exhaustion. Nat Immunol 12, 492–499.

    Article  CAS  Google Scholar 

  • Zhang, L., Yu, X., Zheng, L., Zhang, Y., Li, Y., Fang, Q., Gao, R., Kang, B., Zhang, Q., Huang, J.Y., et al. (2018). Lineage tracking reveals dynamic relationships of T cells in colorectal cancer. Nature 564, 268–272.

    Article  CAS  Google Scholar 

  • Zheng, C., Zheng, L., Yoo, J.K., Guo, H., Zhang, Y., Guo, X., Kang, B., Hu, R., Huang, J.Y., Zhang, Q., et al. (2017). Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing. Cell 169, 1342–1356.e16.

    Article  CAS  Google Scholar 

  • Zheng, L., Qin, S., Si, W., Wang, A., Xing, B., Gao, R., Ren, X., Wang, L., Wu, X., Zhang, J., et al. (2021). Pan-cancer single-cell landscape of tumor-infiltrating T cells. Science 374, abe6474.

    Article  Google Scholar 

  • Zhou, G., and Levitsky, H.I. (2007). Natural regulatory T cells and de novo-induced regulatory T cells contribute independently to tumor-specific tolerance. J Immunol 178, 2155–2162.

    Article  CAS  Google Scholar 

  • Zhou, G., Drake, C.G., and Levitsky, H.I. (2006). Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines. Blood 107, 628–636.

    Article  CAS  Google Scholar 

  • Zou, W. (2006). Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 6, 295–307.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute for Immunology and School of Medicine, Tsinghua University, Beijing, 100084, China

    Xinyi Guo & Chen Dong

  2. Shanghai Immune Therapy Institute, Shanghai Jiaotong University School of Medicine-affiliated Renji Hospital, Shanghai, 200127, China

    Chen Dong

Authors
  1. Xinyi Guo
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  2. Chen Dong
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Corresponding author

Correspondence to Chen Dong.

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The author(s) declare that they have no conflict of interest.

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Guo, X., Dong, C. Zooming on T cells in cancer. Sci. China Life Sci. 65, 1466–1468 (2022). https://doi.org/10.1007/s11427-022-2100-2

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  • DOI: https://doi.org/10.1007/s11427-022-2100-2

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