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Design and biosynthesis of functional protein nanostructures

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Abstract

Proteins are one of the major classes of biomolecules that execute biological functions for maintenance of life. Various kinds of nanostructures self-assembled from proteins have been created in nature over millions of years of evolution, including protein nanowires, layers and nanocages. These protein nanostructures can be reconstructed and equipped with desired new functions. Learning from and manipulating the self-assembly of protein nanostructures not only help to deepen our understanding of the nature of life but also offer new routes to fabricate novel nanomaterials for diverse applications. This review summarizes the recent research progress in this field, focusing on the characteristics, functionalization strategies, and applications of protein nanostructures.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (21890743, 31771103, and 91527302), the National Key Research and Development Program of China (2017YFA0205503), the Strategic Priority Research Program of the Chinese Academy of Sciences (CAS) (XDB29050100), CAS Emergency Project of ASF Research (KJZD-SWL06 and KJZD-SWL07), Youth Innovation Promotion Association of CAS (2014308), and Wuhan Huanghe Talents Program of Science and Technology.

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  1. State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China

    Feng Li, Juan Zhou & Dong Men

  2. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China

    Dianbing Wang & Xian-En Zhan

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Li, F., Wang, D., Zhou, J. et al. Design and biosynthesis of functional protein nanostructures. Sci. China Life Sci. 63, 1142–1158 (2020). https://doi.org/10.1007/s11427-019-1641-6

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