Skip to main content
SpringerLink
Log in

Ultrasound-propelled Janus Au NR-mSiO2 nanomotor for NIR-II photoacoustic imaging guided sonodynamic-gas therapy of large tumors

  • Articles
  • Published:
Science China Chemistry Aims and scope Submit manuscript

Abstract

Varieties of contrast agents have been developed for photoacoustic (PA) and ultrasound (US) imaging of cancers in vivo. However, access of traditional contrast agents into the sites of tumors has been principally through passive infiltration without any external force, preventing their deep penetration into the tissues of the tumors, and hindering the use of PA and US for deep tumor imaging. The concept of micro/nanomotors has been the focus of increasing attention as active theranostic agents due to their active movement in particular fluids, thereby conducting assigned tasks. Herein, US-propelled Janus mesoporous SiO2 partially coated gold nanorods (Au NR-mSiO2) were fabricated for deep tumor NIR-II PA imaging and synergistic sonodynamic-gas therapy. Following US irradiation, 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH) loaded in mSiO2 (Au NR-mSiO2/AIPH) generated N2 microbubbles with high efficiency to achieve nanomotor drive. Due to the deep penetration of US, the nanomotors exhibited a capability to travel deep within sites of tumors, providing enhanced PA/US imaging inside the tumors. Furthermore, the nanomotor based cancer therapy was demonstrated through synergistic N2 gas and sonodynamic therapy. The US-propelled nanomotors demonstrated a novel strategy for the simultaneous PA/US dual imaging deep within tumor tissues and precise therapy of large tumors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Wang C, Fan W, Zhang Z, Wen Y, Xiong L, Chen X. Adv Mater, 2019, 31: 1904329

    Article  CAS  Google Scholar 

  2. Jiang Y, Upputuri PK, Xie C, Zeng Z, Sharma A, Zhen X, Li J, Huang J, Pramanik M, Pu K. Adv Mater, 2019, 31: 1808166

    Article  Google Scholar 

  3. Guo B, Sheng Z, Hu D, Liu C, Zheng H, Liu B. Adv Mater, 2018, 30: 1802591

    Article  Google Scholar 

  4. Liu Y, Bhattarai P, Dai Z, Chen X. Chem Soc Rev, 2019, 48: 2053–2108

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Liu Y, Teng L, Liu HW, Xu C, Guo H, Yuan L, Zhang XB, Tan W. Sci China Chem, 2019, 62: 1275–1285

    Article  CAS  Google Scholar 

  6. Fu Q, Zhu R, Song J, Yang H, Chen X. Adv Mater, 2018, 31: 1805875

    Article  Google Scholar 

  7. Smith BR, Gambhir SS. Chem Rev, 2017, 117: 901–986

    Article  CAS  PubMed  Google Scholar 

  8. Li J, Pu K. Chem Soc Rev, 2019, 48: 38–71

    Article  CAS  PubMed  Google Scholar 

  9. Lyu Y, Li J, Pu K. Small Methods, 2019, 3: 1900553

    Article  CAS  Google Scholar 

  10. Li Z, Fu Q, Ye J, Ge X, Wang J, Song J, Yang H. Angew Chem Int Ed, 2020, 59: 22202–22209

    Article  CAS  Google Scholar 

  11. Zhu R, Su L, Dai J, Li ZW, Bai S, Li Q, Chen X, Song J, Yang H. ACS Nano, 2020, 14: 3991–4006

    Article  CAS  PubMed  Google Scholar 

  12. Zhang W, Wang J, Su L, Chen H, Zhang L, Lin L, Chen X, Song J, Yang H. Sci China Chem, 2020, 63: 1315–1322

    Article  CAS  Google Scholar 

  13. Ye J, Li Z, Fu Q, Li Q, Zhang X, Su L, Yang H, Song J. Adv Funct Mater, 2020, 30: 2001771

    Article  CAS  Google Scholar 

  14. Zhou C, Zhang L, Sun T, Zhang Y, Liu Y, Gong M, Xu Z, Du M, Liu Y, Liu G, Zhang D. Adv Mater, 2021, 33: 2006532

    Article  CAS  Google Scholar 

  15. Wu Z, Li L, Yang Y, Hu P, Li Y, Yang SY, Wang LV, Gao W. Sci Robot, 2019, 4: eaax0613

    Article  PubMed  PubMed Central  Google Scholar 

  16. Jung E, Kang C, Lee J, Yoo D, Hwang DW, Kim D, Park SC, Lim SK, Song C, Lee D. ACS Nano, 2018, 12: 392–401

    Article  CAS  PubMed  Google Scholar 

  17. Tang W, Yang Z, Wang S, Wang Z, Song J, Yu G, Fan W, Dai Y, Wang J, Shan L, Niu G, Fan Q, Chen X. ACS Nano, 2018, 12: 2610–2622

    Article  CAS  PubMed  Google Scholar 

  18. Lin X, Song J, Chen X, Yang H. Angew Chem Int Ed, 2020, 59: 14212–14233

    Article  CAS  Google Scholar 

  19. Lindner JR. Nat Rev Drug Discov, 2004, 3: 527–533

    Article  CAS  PubMed  Google Scholar 

  20. Liang S, Deng X, Ma P, Cheng Z, Lin J. Adv Mater, 2020, 32: 2003214

    Article  CAS  Google Scholar 

  21. Sun D, Pang X, Cheng Y, Ming J, Xiang S, Zhang C, Lv P, Chu C, Chen X, Liu G, Zheng N. ACS Nano, 2020, 14: 2063–2076

    Article  CAS  PubMed  Google Scholar 

  22. Lin X, Liu S, Zhang X, Zhu R, Chen S, Chen X, Song J, Yang H. Angew Chem Int Ed, 2020, 59: 1682–1688

    Article  CAS  Google Scholar 

  23. Ma A, Chen H, Cui Y, Luo Z, Liang R, Wu Z, Chen Z, Yin T, Ni J, Zheng M, Cai L. Small, 2019, 15: 1804028

    Article  Google Scholar 

  24. Lin X, Qiu Y, Song L, Chen S, Chen X, Huang G, Song J, Chen X, Yang H. Nanoscale Horiz, 2019, 4: 747–756

    Article  CAS  Google Scholar 

  25. Bai S, Yang N, Wang X, Gong F, Dong Z, Gong Y, Liu Z, Cheng L. ACS Nano, 2020, 14: 15119–15130

    Article  PubMed  Google Scholar 

  26. Chen L, Zhou SF, Su L, Song J. ACS Nano, 2019, 13: 10887–10917

    Article  CAS  PubMed  Google Scholar 

  27. Lu Q, Lu T, Xu M, Yang L, Song Y, Li N. Biomaterials, 2020, 257: 120236

    Article  CAS  PubMed  Google Scholar 

  28. Yu L, Hu P, Chen Y. Adv Mater, 2018, 30: 1801964

    Article  Google Scholar 

  29. Wu Y, Yuan M, Song J, Chen X, Yang H. ACS Nano, 2019, 13: 8505–8511

    Article  CAS  PubMed  Google Scholar 

  30. Wang W, Wu Z, He Q. View, 2020, 1: 20200005

    Article  Google Scholar 

  31. Peng F, Tu Y, Wilson DA. Chem Soc Rev, 2017, 46: 5289–5310

    Article  CAS  PubMed  Google Scholar 

  32. Wang B, Kostarelos K, Nelson BJ, Zhang L. Adv Mater, 2021, 33: 2002047

    Article  CAS  Google Scholar 

  33. Ma X, Hahn K, Sanchez S. J Am Chem Soc, 2015, 137: 4976–4979

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Ma X, Wang X, Hahn K, Sanchez S. ACS Nano, 2016, 10: 3597–3605

    Article  CAS  PubMed  Google Scholar 

  35. Wilson DA, Nolte RJM, van Hest JCM. Nat Chem, 2012, 4: 268–274

    Article  CAS  PubMed  Google Scholar 

  36. Xuan M, Wu Z, Shao J, Dai L, Si T, He Q. J Am Chem Soc, 2016, 138: 6492–6497

    Article  CAS  PubMed  Google Scholar 

  37. Shao L, Käll M. Adv Funct Mater, 2018, 28: 1706272

    Article  Google Scholar 

  38. Lin Z, Fan X, Sun M, Gao C, He Q, Xie H. ACS Nano, 2018, 12: 2539–2545

    Article  CAS  PubMed  Google Scholar 

  39. Wang J, Dong R, Wu H, Cai Y, Ren B. Nano-Micro Lett, 2019, 12: 11

    Article  Google Scholar 

  40. Chen T, Chen G, Xing S, Wu T, Chen H. Chem Mater, 2010, 22: 3826–3828

    Article  CAS  Google Scholar 

  41. Li S, Liu R, Jiang X, Qiu Y, Song X, Huang G, Fu N, Lin L, Song J, Chen X, Yang H. ACS Nano, 2019, 13: 2103–2113

    CAS  PubMed  Google Scholar 

  42. Zhang Q, Zhang T, Ge J, Yin Y. Nano Lett, 2008, 8: 2867–2871

    Article  CAS  PubMed  Google Scholar 

  43. Shen S, Zhu C, Huo D, Yang M, Xue J, Xia Y. Angew Chem Int Ed, 2017, 56: 8801–8804

    Article  CAS  Google Scholar 

  44. Li Z, Hu Y, Fu Q, Liu Y, Wang J, Song J, Yang H. Adv Funct Mater, 2020, 30: 1905758

    Article  CAS  Google Scholar 

  45. Li C, Zhang Y, Li Z, Mei E, Lin J, Li F, Chen C, Qing X, Hou L, Xiong L, Hao H, Yang Y, Huang P. Adv Mater, 2018, 30: 1706150

    Article  Google Scholar 

Download references

Acknowledgements

This research was supported by the National Natural Science Foundation of China (21874024, 22027805, 21804068), the National Key R&D Program of China (2020YFA0210800), the joint re-search projects of Health and Education Commission of Fujian Province (2019-WJ-20), and the Natural Science Foundation of Fujian Province (2020J02012).

Author information

Authors and Affiliations

  1. MOE Key Laboratory for Analytical Science of Food Safety and Biology, Ministry of Education, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

    Jiamin Ye, Qinrui Fu, Luntao Liu, Lanlan Chen, Xuan Zhang, Qingqing Li, Zhi Li, Lichao Su, Rong Zhu, Jibin Song & Huanghao Yang

Authors
  1. Jiamin Ye
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qinrui Fu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Luntao Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lanlan Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xuan Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Qingqing Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zhi Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Lichao Su
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Rong Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Jibin Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Huanghao Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Lanlan Chen, Jibin Song or Huanghao Yang.

Ethics declarations

Conflict of interest The authors declare no conflict of interest.

Supporting Information

11426_2021_1070_MOESM1_ESM.pdf

Ultrasound-Propelled Janus Au NR-mSiO2 Nanomotor for NIR-II Photoacoustic Imaging Guided Sonodynamic-Gas Therapy of Large Tumors

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ye, J., Fu, Q., Liu, L. et al. Ultrasound-propelled Janus Au NR-mSiO2 nanomotor for NIR-II photoacoustic imaging guided sonodynamic-gas therapy of large tumors. Sci. China Chem. 64, 2218–2229 (2021). https://doi.org/10.1007/s11426-021-1070-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11426-021-1070-6

Keywords

Search

Navigation