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Recent advances in target identification by natural product based chemical probes

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Abstract

Natural products have been extensively used to treat diseases throughout human history. These are mainly because natural products normally target biological macromolecules selectively. Target identification could help us to develop new therapeutic agents and discover new biological pathways underlying human diseases. Herein, we highlight some recent examples of using natural products and their derivatives as chemical probes to identify the molecular targets and elucidate mode of action.

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Authors and Affiliations

  1. Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China

    Benke Hong & Xiaoguang Lei

  2. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, China

    Benke Hong

  3. National Institute of Biological Sciences, Beijing, 102206, China

    Ting Dong & Xiaoguang Lei

  4. Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China

    Ting Dong

Authors
  1. Benke Hong
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  2. Ting Dong
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  3. Xiaoguang Lei
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Correspondence to Xiaoguang Lei.

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Hong, B., Dong, T. & Lei, X. Recent advances in target identification by natural product based chemical probes. Sci. China Chem. 59, 1088–1092 (2016). https://doi.org/10.1007/s11426-016-0063-5

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  • DOI: https://doi.org/10.1007/s11426-016-0063-5

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