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Associations between maternal serum phytoestrogens and liver function markers: a cross-sectional study from China

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Abstract

Phytoestrogens (PEs) may harm liver function. However, studies in pregnant women are limited. Our study was conducted in pregnant women to assess the effect of serum PEs on liver function markers. We conducted a cross-sectional study focusing in the first trimester of pregnancy. A total of 352 pregnant women were enrolled in the study. We used generalized linear model (GLM) to explore the associations between each PE and each marker of liver function. We used Quantile g-computation (Qgcomp) and Bayesian kernel machine regression (BKMR) models to explore the associations between mixed exposure to all PEs and liver function markers. The GLM results showed that equol (EQU), daidzein (DAD), genistein (GEN), enterolactone (ENT), and enterodiol (END) were negatively correlated with albumin (ALB). DAD and GEN were associated with elevated alanine aminotransferase (ALT). DAD, GEN, naringin (NAR), and glycitein (GLY) were related to elevated aspartate aminotransferase (AST). Mixed exposure model results showed that the mixture of PEs was associated with reduced ALB. Our results support the existence of associations between PEs and maternal liver function in the first trimester. Emphasizing the detrimental associations between serum PEs and liver function in pregnant women is essential to ensure maternal liver health during pregnancy.

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Acknowledgements

We sincerely acknowledge the mothers for providing their blood samples. We are very grateful to the institutions for their support on collecting blood samples and providing medical records.

Funding

This research was funded by the National Natural Science Foundation of China (81460517) and (81860587), Guangxi Key Research Program (AB17195012), and Research basic ability improvement project for young and middle-aged teachers in universities in Guangxi (2021KY0102).

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Authors and Affiliations

  1. Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China

    Xiaogang Wang, Lei Lei, Lijun Wang, Erna Guo, Jinxiu Li, Weiyan Huang, Lihong Zhou, Jiatong Deng, Wanling Chen, Chanhua Li, Xiaoqiang Qiu & Xiaoyun Zeng

  2. Nanning Wuming District Maternal and Child Health Care Hospital, Nanning, 530100, Guangxi, China

    Dandan Huang

  3. Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, Nanning, 530031, Guangxi, China

    Jianchun Huang

  4. Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China

    Dongping Huang

  5. Department of Maternal, Child and Adolescent Health, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China

    Shun Liu

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  1. Xiaogang Wang
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Contributions

Xiaogang Wang: methodology, formal analysis, investigation, data curation, writing—original draft, visualization. Lei Lei: conceptualization, investigation, data curation, writing—original draft, writing—review and editing, funding acquisition. Lijun Wang: writing—review and editing. Dandan Huang: resources. Jianchun Huang: resources. Erna Guo: investigation, resources. Jinxiu Li: investigation. Weiyan Huang: data curation. Lihong Zhou: data curation. Jiatong Deng: data curation. Wanling Chen: data curation. Chanhua Li: data curation. Xiaoqiang Qiu: supervision, project administration, funding acquisition. Dongping Huang: supervision, project administration, funding acquisition. Shun Liu: supervision, project administration. Xiaoyun Zeng: conceptualization, resources, data curation, writing—review and editing, supervision, project administration, funding acquisition.

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Correspondence to Xiaoyun Zeng.

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The ethical review of this study was approved by the ethical review committee of Guangxi Medical University (approval number: 20140305–001).

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Xiaogang Wang, Lei Lei, and Lijun Wang are co-first authors: These authors contributed equally to this work.

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Wang, X., Lei, L., Wang, L. et al. Associations between maternal serum phytoestrogens and liver function markers: a cross-sectional study from China. Environ Sci Pollut Res 30, 122038–122050 (2023). https://doi.org/10.1007/s11356-023-30761-9

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