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Association of urinary bisphenol A with chronic obstructive pulmonary disease–related diseases: evidence from the National Health and Nutrition Examination Survey database (2005–2016)

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Abstract

In vivo and in vitro studies have found that exposure to bisphenol A (BPA) can lead to pulmonary diseases, but there exists little evidence regarding the association between urinary BPA level and chronic obstructive pulmonary disease (COPD)-related diseases in the population. National Health and Nutrition Examination Survey data, from 2005 to 2016, were utilized in this study. Participants who self-reported having emphysema, chronic bronchitis, or COPD were defined as having COPD-related diseases. A multivariate logistic regression analysis was used to analyze the association of urinary BPA with COPD-related diseases in the overall population and according to sex. Three separate models including different covariates were used in our analyses. The association of urinary BPA with COPD-related diseases in different subgroups (age, smoking status, participants belonging to “ever had asthma” and “ever had cardiovascular disease”) other than sex was also analyzed. Based on the different models, 9189, 7006, and 6946 participants were used in our study. BPA was found to be significantly associated with COPD-related diseases in all models. The concentration of BPA in urine was significantly associated with COPD-related diseases regardless of whether BPA concentration was treated as a continuous variable (odds ratio (OR): 1.24, 95% confidence interval (CI): 1.11–1.38, in model 3) or as tertiles (OR: 2.01, 95% CI: 1.49–2.72, between the lowest group and highest group, in model 3). This association was significant among male but not female participants. BPA also demonstrated a significant association with emphysema and chronic bronchitis in adults, particularly in males. No significant interaction was found for all the other subgroup analyses. Urinary BPA was associated with COPD-related diseases in adult participants, especially males.

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Data availability

The datasets used and analyzed during the current study are available at https://www.cdc.gov/nchs/nhanes/about_nhanes.htm.

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Acknowledgements

This study utilized data from the National Health and Nutrition Examination Survey (NHANES). The authors thank all contributors and participants in the NHANES.

Funding

This study was supported by the Clinical Research Plan of SHDC (No. SHDC2020CR3043B).

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Author notes

  1. Ren Zhou and Shanliang Jin contributed equally to this work.

Authors and Affiliations

  1. Department of Anaesthesiology, The Ninth People’s Hospital of Shanghai, Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, People’s Republic of China

    Ren Zhou, Shanliang Jin, Chenyu Jin, Yu Sun, Lei Zhang, Jia Yan & Hong Jiang

Authors
  1. Ren Zhou
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  2. Shanliang Jin
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  3. Chenyu Jin
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  4. Yu Sun
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  6. Jia Yan
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  7. Hong Jiang
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Contributions

Project administration: Yu Sun and Shanliang Jin. Resources: Jia Yan. Software: Ren Zhou. Supervision: Hong Jiang. Validation: Chenyu Jin. Visualization: Lei Zhang. Roles/writing of original draft: Ren Zhou. All authors have read and approved the final manuscript. The findings and conclusions of this report are those of the authors and do not necessarily represent the official position of the CDC/ATSDR.

Corresponding author

Correspondence to Hong Jiang.

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Ethics approval and consent to participate

The CDC/ATSDR determined that our research did not meet the criteria for human research as per federal regulations and therefore did not require review. All participants in the survey consented to participation as well as storage of blood samples for future research.

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Not applicable. There are no individual-level data in our publication.

Competing interests

The authors declare no competing interests.

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Responsible Editor: Lotfi Aleya

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Zhou, R., Jin, S., Jin, C. et al. Association of urinary bisphenol A with chronic obstructive pulmonary disease–related diseases: evidence from the National Health and Nutrition Examination Survey database (2005–2016). Environ Sci Pollut Res 30, 33170–33180 (2023). https://doi.org/10.1007/s11356-022-24572-7

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