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Pro-inflammatory or anti-inflammatory effects of pulsed magnetic field treatments in rats with experimental acute inflammation

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Abstract

In this study, we evaluated the possible effects of sequenced pulsed magnetic fields (PMF) of 1-mT treatments with designed different frequencies (PMF-1—1, 3, 5, 7 Hz or PMF-2—7, 9, 12, 14 Hz) on the inflammatory signs such as abnormal pain behaviors, hyperalgesia and allodynia, edema, and fever in carrageenan (CG)-induced hind paw inflammation model in rats. Paw tissues were also histologically examined. PMF exposure was applied 3 times in 24 h. CG injection gradually decreased the thermal latencies and mechanical threshold and caused significant increases in temperature and mass of paw. PMF treatments significantly reduced the temperature and mass in the paw of rats with inflammation. PMF-1 treatments caused significant increases in the latencies and thresholds. However, administration of PMF-2 treatment was significantly decreased the latency and threshold. Furthermore, the histological pieces of evidence also suggested the anti-inflammatory effects of PMF-1 treatments or inflammatory actions of PMF-2 treatments. Findings presented in this paper suggest that 1-mT PMF treatments may have anti-edematous and antipyretics activities in inflamed rats. However, the effects of PMF treatments on abnormal pain hypersensitivities may be different. PMF treatments may make inflammatory pain relief or worse in inflamed rats depending on the PMF frequencies in sequence.

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Acknowledgments

We thank Dr. Tuba Ozcan Metin for the histological examinations and assistance.

Funding

This study was supported by the Scientific and Technological Research Council of Turkey, grant number 116S502.

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Authors and Affiliations

  1. Department of Biophysics, Faculty of Medicine, Bolu Abant Izzet Baysal University, 14030, Bolu, Turkey

    Tufan Mert

  2. Department of Biophysics, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey

    Selma Yaman

Authors
  1. Tufan Mert
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  2. Selma Yaman
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Correspondence to Tufan Mert.

Ethics declarations

All experimental procedures were approved by the Kahramanmaras Sutcu Imam University institutional animal care and use committee (2016/03/03/04).

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The authors declare that they have no conflict of interest.

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Responsible Editor: Mohamed M. Abdel-Daim

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Mert, T., Yaman, S. Pro-inflammatory or anti-inflammatory effects of pulsed magnetic field treatments in rats with experimental acute inflammation. Environ Sci Pollut Res 27, 31543–31554 (2020). https://doi.org/10.1007/s11356-020-09401-z

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  • DOI: https://doi.org/10.1007/s11356-020-09401-z

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