Skip to main content

Advertisement

SpringerLink
Log in

Mechanisms and pathogenesis underlying environmental chemical-induced necroptosis

  • Review Article
  • Published:
Environmental Science and Pollution Research Aims and scope Submit manuscript

Abstract

Necroptosis is a regulated cell death that is governed by mixed lineage kinase domain-like, receptor-interacting serine-threonine kinase 3 and commonly displays with necrosis morphological characteristics. This study examined the molecular mechanisms involved in the chemical-induced necroptosis where a systematic evaluation of experimental studies addressing this issue is missing. We strictly reviewed all scientific reports related to our search terms including “necroptosis” or “programmed necrosis”, “environmental chemicals” or “air pollutants” or “pesticides” or “nanoparticles” and “Medicines” from 2009 to 2019. Manuscripts that met the objective of this study were included for further evaluations. Studies showed that several pathological contexts like cancer, neurodegenerative disorders, and inflammatory diseases were related to necroptosis. Furthermore, multiple chemical-induced cytotoxic effects, such as DNA damage, mitochondrial dysregulation, oxidative damage, lipid peroxidation, endoplasmic reticulum disruption, and inflammation are also associated with necroptosis. The main environmental exposures that are related to necroptosis are air pollutants (airborne particulate matter, cadmium, and hydrogen sulfide), nanoparticles (gold, silver, and silica), pesticides (endosulfan, cypermethrin, chlorpyrifos, and paraquat), and tobacco smoke. To sum up, air pollutants, pesticides, and nanoparticles could potentially affect human health via disruption of cell growth and induction of necroptosis. Understanding the exact molecular pathogenesis of these environmental chemicals needs further comprehensive research to provide innovative concepts for the prevention approaches and introduce novel targets for the amelioration of a range of human health problems.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

Abbreviations

cIAP:

cellular inhibitor of apoptosis protein

COPD:

chronic obstructive pulmonary disease

DAMPs:

aamage-associated molecular patterns

FADD:

Fas-associated protein with a death domain

IKK:

IκB kinase

IL-1β:

interleukin 1 beta

LUBAC:

linear ubiquitin chain assembly complex

MAPK:

mitogen-activated protein kinase

MLKL:

mixed lineage kinase domain-like

NOX1:

NADPH oxidase 1

Nec-1:

necroptosis-specific inhibitor-1

NEMO:

nuclear factor-κB essential modulator

NF-kB:

nuclear factor kappa B

RHIM:

RIP homotypic interaction motif

RIP:

receptor-interacting protein

RIPK:

receptor-interacting protein kinase

ROS:

reactive oxygen species

PMA:

phorbol 12-myristate 13-acetate

TAK:

transforming growth factor β-activated kinase 1

TRAF:

TNFR-associated factor

TLR:

Toll-like receptor

TRADD:

TNFα receptor-associated death domain

TNF:

tumor necrosis factor

TNFR:

Tumor necrosis factor receptor

TRAIL:

TNF-related apoptosis-inducing ligand

References

  • Arya BD, Mittal S, Joshi P, Pandey AK, Ramirez-Vick JE, Singh SP (2018) Graphene oxide–chloroquine nanoconjugate induce necroptotic death in A549 cancer cells through autophagy modulation. Nanomedicine 13:2261–2282

    CAS  Google Scholar 

  • Asharani P, Hande MP, Valiyaveettil S (2009) Anti-proliferative activity of silver nanoparticles. BMC Cell Biol 10:65

    CAS  Google Scholar 

  • Askari H, Seifi B, Kadkhodaee M, Sanadgol N, Elshiekh M, Ranjbaran M, Ahghari P (2018) Protective effects of hydrogen sulfide on chronic kidney disease by reducing oxidative stress, inflammation and apoptosis. EXCLI J 17:14

    Google Scholar 

  • Basit F, Cristofanon S, Fulda S (2013) Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes. Cell Death Differ 20:1161–1173

    CAS  Google Scholar 

  • Bauer AT, Strozyk EA, Gorzelanny C, Westerhausen C, Desch A, Schneider MF, Schneider SW (2011) Cytotoxicity of silica nanoparticles through exocytosis of von Willebrand factor and necrotic cell death in primary human endothelial cells. Biomaterials 32:8385–8393

    CAS  Google Scholar 

  • Brandes RP, Weissmann N, Schröder K (2014) Nox family NADPH oxidases: molecular mechanisms of activation. Free Radic Biol Med 76:208–226

    CAS  Google Scholar 

  • Braydich-Stolle LK, Schaeublin NM, Murdock RC, Jiang J, Biswas P, Schlager JJ, Hussain SM (2009) Crystal structure mediates mode of cell death in TiO 2 nanotoxicity. J Nanopart Res 11:1361–1374

    CAS  Google Scholar 

  • Cai Z et al (2014) Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat Cell Biol 16:55

    CAS  Google Scholar 

  • Carlson C, Hussain SM, Schrand AM, Braydich-Stolle LK, Hess KL, Jones RL, Schlager JJ (2008) Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. J Phys Chem B 112:13608–13619

    CAS  Google Scholar 

  • Chi Q, Wang D, Hu X, Li S, Li S (2019) Hydrogen sulfide gas exposure induces necroptosis and promotes inflammation through the MAPK/NF-κB pathway in broiler spleen oxidative medicine and cellular longevity 2019

  • Cho YS (2018) The role of necroptosis in the treatment of diseases. BMB Rep 51:219

    CAS  Google Scholar 

  • Cho YS, Park HL (2017) Exploitation of necroptosis for treatment of caspase-compromised cancers. Oncol Lett 14:1207–1214

    CAS  Google Scholar 

  • Cho Y, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK-M (2009) Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137:1112–1123

    CAS  Google Scholar 

  • Choi M-J et al. (2019) RIP3-dependent necroptosis promotes cisplatin-induced ototoxicity

  • Ciftci H, TÜRK M, TAMER U, Karahan S, Menemen Y (2013) Silver nanoparticles: cytotoxic, apoptotic, and necrotic effects on MCF-7 cells. Turk J Biol 37:573–581

    CAS  Google Scholar 

  • Cover C, Liu J, Farhood A, Malle E, Waalkes MP, Bajt ML, Jaeschke H (2006) Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 216:98–107

    CAS  Google Scholar 

  • De Stefano D, Carnuccio R, Maiuri MC (2012) Nanomaterials toxicity and cell death modalities. J Drug Deliv:2012

  • Degterev A et al (2005) Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 1:112

    CAS  Google Scholar 

  • Dondelinger Y et al (2013) RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition. Cell Death Differ 20:1381

    CAS  Google Scholar 

  • Dondelinger Y et al (2014) MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates. Cell Rep 7:971–981

    CAS  Google Scholar 

  • Dondelinger Y, Jouan-Lanhouet S, Divert T, Theatre E, Bertin J, Gough PJ, Giansanti P, Heck AJR, Dejardin E, Vandenabeele P, Bertrand MJM (2015) NF-κB-independent role of IKKα/IKKβ in preventing RIPK1 kinase-dependent apoptotic and necroptotic cell death during TNF signaling. Mol Cell 60:63–76

    CAS  Google Scholar 

  • Ebrahimi R, Sepand MR, Seyednejad SA, Omidi A, Akbariani M, Gholami M, Sabzevari O (2019) Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats. DARU-J Pharm Sci 27:721–733

  • Fan H, Tang HB, Kang J, Shan L, Song H, Zhu K, Wang J, Ju G, Wang YZ (2015) Involvement of endoplasmic reticulum stress in the necroptosis of microglia/macrophages after spinal cord injury. Neuroscience 311:362–373

    CAS  Google Scholar 

  • Farasat M, Niazvand F, Khorsandi L (2020) Zinc oxide nanoparticles induce necroptosis and inhibit autophagy in MCF-7 human breast cancer cells. Biologia 75:161–174

    CAS  Google Scholar 

  • Feng S, Yang Y, Mei Y, Ma L, Zhu DE, Hoti N, Castanares M, Wu M (2007) Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cell Signal 19:2056–2067

    CAS  Google Scholar 

  • Feoktistova M et al (2011) cIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 43:449–463

    CAS  Google Scholar 

  • Festjens N, Kalai M, Smet J, Meeus A, Van Coster R, Saelens X, Vandenabeele P (2006) Butylated hydroxyanisole is more than a reactive oxygen species scavenger. Cell Death Differ 13:166

    CAS  Google Scholar 

  • Florean C, Song S, Dicato M, Diederich M (2019) Redox biology of regulated cell death in cancer: a focus on necroptosis and ferroptosis. Free Radic Biol Med

  • Fulda S (2016) Regulation of necroptosis signaling and cell death by reactive oxygen species. Biol Chem 397:657–660

    CAS  Google Scholar 

  • Galluzzi L, Kepp O, Chan FK-M, Kroemer G (2017) Necroptosis: mechanisms and relevance to disease. Annu Rev Pathol 12:103–130

    CAS  Google Scholar 

  • García-Hevia L et al (2016) Nano-ZnO leads to tubulin macrotube assembly and actin bundling, triggering cytoskeletal catastrophe and cell necrosis. Nanoscale 8:10963–10973

    Google Scholar 

  • Gong Y, Fan Z, Luo G, Yang C, Huang Q, Fan K, Cheng H, Jin K, Ni Q, Yu X, Liu C (2019) The role of necroptosis in cancer biology and therapy. Mol Cancer 18:100

    Google Scholar 

  • Grootjans S, Berghe TV, Vandenabeele P (2017) Initiation and execution mechanisms of necroptosis: an overview. Cell Death Differ 24:1184

    CAS  Google Scholar 

  • Harhaji L et al (2007) Multiple mechanisms underlying the anticancer action of nanocrystalline fullerene. Eur J Pharmacol 568:89–98. https://doi.org/10.1016/j.ejphar.2007.04.041

    Article  CAS  Google Scholar 

  • Hassani S et al (2015) Protective effects of curcumin and vitamin E against chlorpyrifos-induced lung oxidative damage. Hum Exp Toxicol 34:668–676

    CAS  Google Scholar 

  • He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X (2009) Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-α. Cell 137:1100–1111

    CAS  Google Scholar 

  • Hinojosa M, Gutiérrez-Praena D, Prieto A, Guzmán-Guillén R, Jos A, Camean A (2019) Neurotoxicity induced by microcystins and cylindrospermopsin: a review. Sci Total Environ

  • Hirayama N, Aki T, Funakoshi T, Noritake K, Unuma K, Uemura K (2018) Necrosis in human neuronal cells exposed to paraquat. J Toxicol Sci 43:193–202

    CAS  Google Scholar 

  • Huang X, Xiao F, Li Y, Qian W, Ding W, Ye X (2018) Bypassing drug resistance by triggering necroptosis: recent advances in mechanisms and its therapeutic exploitation in leukemia. J Exp Clin Cancer Res 37:310

    CAS  Google Scholar 

  • Hussain S, Hess K, Gearhart J, Geiss K, Schlager J (2005) In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol in Vitro 19:975–983

    CAS  Google Scholar 

  • Kaczmarek A, Vandenabeele P, Krysko DV (2013) Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity 38:209–223

    CAS  Google Scholar 

  • Kaiser WJ et al (2013) Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem 288:31268–31279

    CAS  Google Scholar 

  • Keshavarz-Bahaghighat H et al (2018) Acetyl-l-carnitine attenuates arsenic-induced oxidative stress and hippocampal mitochondrial dysfunction. Biol Trace Elem Res 184:422–435

    CAS  Google Scholar 

  • Kim Y-S, Morgan MJ, Choksi S, Liu Z-G (2007) TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell 26:675–687

    CAS  Google Scholar 

  • Kord Mostafapour F et al (2018) Characterizing of fine particulate matter (PM1) on the platforms and outdoor areas of underground and surface subway stations. Hum Ecol Risk Assess 24:1016–1029

    CAS  Google Scholar 

  • Krumschnabel G, Ebner HL, Hess MW, Villunger A (2010) Apoptosis and necroptosis are induced in rainbow trout cell lines exposed to cadmium. Aquat Toxicol 99:73–85

    CAS  Google Scholar 

  • LaCasse E, Mahoney D, Cheung H, Plenchette S, Baird S, Korneluk R (2008) IAP-targeted therapies for cancer. Oncogene 27:6252

    CAS  Google Scholar 

  • Lai L, Jin J-C, Xu Z-Q, Mei P, Jiang F-L, Liu Y (2015) Necrotic cell death induced by the protein-mediated intercellular uptake of CdTe quantum dots. Chemosphere 135:240–249

    CAS  Google Scholar 

  • Lalaoui N, Lindqvist LM, Sandow JJ, Ekert PG (2015) The molecular relationships between apoptosis, autophagy and necroptosis. In: Seminars in cell & developmental biology. Elsevier, pp 63–69

  • Li J et al (2012a) The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell 150:339–350

    CAS  Google Scholar 

  • Li L et al (2012b) Controllable synthesis of monodispersed silver nanoparticles as standards for quantitative assessment of their cytotoxicity. Biomaterials 33:1714–1721

    CAS  Google Scholar 

  • Li Y et al (2018) Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection. Cell Death Differ 25:1304

    CAS  Google Scholar 

  • Li H, Wang Y, Yang H, Zhang Y, Xing L, Wang J, Zheng N (2019) Furosine, a Maillard reaction product, triggers necroptosis in hepatocytes by regulating the RIPK1/RIPK3/MLKL pathway. Int J Mol Sci 20:2388

    Google Scholar 

  • Lin Y, Devin A, Rodriguez Y, Liu Z-G (1999) Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev 13:2514–2526

    CAS  Google Scholar 

  • Linkermann A, Green DR (2014) Necroptosis. N Engl J Med 370:455–465

    CAS  Google Scholar 

  • Liu M, Gu X, Zhang K, Ding Y, Wei X, Zhang X, Zhao Y (2013) Gold nanoparticles trigger apoptosis and necrosis in lung cancer cells with low intracellular glutathione. J Nanopart Res 15:1745

    Google Scholar 

  • Liu T, Bao Y, Wang Y, Jiang J (2015) The role of necroptosis in neurosurgical diseases. Braz J Med Biol Res 48:292–298

    CAS  Google Scholar 

  • Liu Y et al (2019) RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy. Int J Mol Med

  • Lu JV et al (2011) Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc Natl Acad Sci 108:15312–15317

    CAS  Google Scholar 

  • Luedde M, Lutz M, Carter N, Sosna J, Jacoby C, Vucur M, Gautheron J, Roderburg C, Borg N, Reisinger F, Hippe HJ, Linkermann A, Wolf MJ, Rose-John S, Lüllmann-Rauch R, Adam D, Flögel U, Heikenwalder M, Luedde T, Frey N (2014) RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction. Cardiovasc Res 103:206–216

    CAS  Google Scholar 

  • Ma Y-H, Huang C-P, Tsai J-S, Shen M-Y, Li Y-K, Lin L-Y (2011) Water-soluble germanium nanoparticles cause necrotic cell death and the damage can be attenuated by blocking the transduction of necrotic signaling pathway. Toxicol Lett 207:258–269

    CAS  Google Scholar 

  • Matt S, Hofmann TG (2016) The DNA damage-induced cell death response: a roadmap to kill cancer cells. Cell Mol Life Sci 73:2829–2850

    CAS  Google Scholar 

  • Meng X-M et al (2018) NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation. Lab Investig 98:63

    CAS  Google Scholar 

  • Micheau O, Tschopp J (2003) Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. 114:181–Cell, 190

  • Mishra AR, Zheng J, Tang X, Goering PL (2016) Silver nanoparticle-induced autophagic-lysosomal disruption and NLRP3-inflammasome activation in HepG2 cells is size-dependent. Toxicol Sci 150:473–487. https://doi.org/10.1093/toxsci/kfw011

    Article  CAS  Google Scholar 

  • Mocarski ES, Guo H, Kaiser WJ (2015) Necroptosis: the Trojan horse in cell autonomous antiviral host defense. Virology 479:160–166

    Google Scholar 

  • Moquin DM, McQuade T, Chan FK-M (2013) CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. PLoS One 8:e76841

    CAS  Google Scholar 

  • Murakami Y et al (2014) Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration. Cell Death Differ 21:270

    CAS  Google Scholar 

  • Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RCJ, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS (2013) The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity 39:443–453

    CAS  Google Scholar 

  • Niu Y, Tang E, Zhang Q (2019) Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction. Toxicol Res 8:1042–1049

    CAS  Google Scholar 

  • O'Donnell MA, Legarda-Addison D, Skountzos P, Yeh WC, Ting AT (2007) Ubiquitination of RIP1 regulates an NF-κB-independent cell-death switch in TNF signaling. Curr Biol 17:418–424

    CAS  Google Scholar 

  • Oh W-K, Kim S, Kwon O, Jang J (2011) Shape-dependent cytotoxicity of polyaniline nanomaterials in human fibroblast cells. J Nanosci Nanotechnol 11:4254–4260

    CAS  Google Scholar 

  • Pan Y, Neuss S, Leifert A, Fischler M, Wen F, Simon U, Schmid G, Brandau W, Jahnen-Dechent W (2007) Size-dependent cytotoxicity of gold nanoparticles. Small 3:1941–1949

    CAS  Google Scholar 

  • Pan Y et al (2009) Gold nanoparticles of diameter 1.4 nm trigger necrosis by oxidative stress and mitochondrial damage. 5:2067–Small, 2076

  • Pasparakis M, Vandenabeele P (2015) Necroptosis and its role in inflammation. Nature 517:311

    CAS  Google Scholar 

  • Pouwels SD et al (2015) Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice. Am J Phys Lung Cell Mol Phys 310:L377–L386

    Google Scholar 

  • Radogna F, Dicato M, Diederich M (2015) Cancer-type-specific crosstalk between autophagy, necroptosis and apoptosis as a pharmacological target. Biochem Pharmacol 94:1–11

    CAS  Google Scholar 

  • Rahman M et al (2009) Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles. Toxicol Lett 187:15–21

    CAS  Google Scholar 

  • Ramroodi N, Niazi AA, Sanadgol N, Ganjali Z, Sarabandi V (2013) Evaluation of reactive Epstein-Barr virus (EBV) in Iranian patient with different subtypes of multiple sclerosis (MS). Braz J Infect Dis 17(2):156–163

    Google Scholar 

  • Raszewski G, Lemieszek MK, Lukawski K (2016) Cytotoxicity induced by cypermethrin in human neuroblastoma cell line SH-SY5Y. Ann Agric Environ Med 23

  • Ren L et al (2016) Silica nanoparticles induce reversible damage of spermatogenic cells via RIPK1 signal pathways in C57 mice. Int J Nanomedicine 11:2251

    CAS  Google Scholar 

  • Safa AR, Pollok KE (2011) Targeting the anti-apoptotic protein c-FLIP for cancer therapy. Cancers 3:1639–1671

    CAS  Google Scholar 

  • Sanadgol N, Golab F, Askari H, Moradi F, Ajdary M, Mehdizadeh M (2018) Alpha-lipoic acid mitigates toxic-induced demyelination in the corpus callosum by lessening of oxidative stress and stimulation of polydendrocytes proliferation. Metab Brain Dis 33:27–37

    CAS  Google Scholar 

  • Saravani S, Miri-Moghaddam E, Sanadgol N, Kadeh H, Nazeri MR (2014) Human herpesvirus-6 and Epstein–Barr virus infections at different histopathological grades of oral squamous cell carcinomas. Int J Prev Med 5:1231

    Google Scholar 

  • Saveljeva S, Mc Laughlin S, Vandenabeele P, Samali A, Bertrand M (2015) Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells. Cell Death Dis 6:e1587

    CAS  Google Scholar 

  • Schaeublin NM, Braydich-Stolle LK, Schrand AM, Miller JM, Hutchison J, Schlager JJ, Hussain SM (2011) Surface charge of gold nanoparticles mediates mechanism of toxicity. Nanoscale 3:410–420

    CAS  Google Scholar 

  • Sepand MR et al (2020) Impact of plasma concentration of transferrin on targeting capacity of nanoparticles. Nanoscale 12:4935–4944

    CAS  Google Scholar 

  • Serasanambati M, Chilakapati SR (2016) Function of nuclear factor kappa B (NF-kB) in human diseases-a review. South Ind J Biol Sci 2:368–387

    Google Scholar 

  • Shindo R, Kakehashi H, Okumura K, Kumagai Y, Nakano H (2013) Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation. Biochem Biophys Res Commun 436:212–216

    CAS  Google Scholar 

  • Smith C, Hansch C (2000) The relative toxicity of compounds in mainstream cigarette smoke condensate. Food Chem Toxicol 38:637–646

    CAS  Google Scholar 

  • Sonkusre P, Cameotra SS (2017) Biogenic selenium nanoparticles induce ROS-mediated necroptosis in PC-3 cancer cells through TNF activation. J Nanobiotechnol 15:43

    Google Scholar 

  • Su Z, Yang Z, Xie L, DeWitt J, Chen Y (2016) Cancer therapy in the necroptosis era. Cell Death Differ 23:748–756

    CAS  Google Scholar 

  • Sun H, Jia J, Jiang C, Zhai S (2018) Gold nanoparticle-induced cell death and potential applications in nanomedicine. Int J Mol Sci 19:754

    Google Scholar 

  • Tavakol S, Hoveizi E, Kharrazi S, Tavakol B, Karimi S, Rezayat Sorkhabadi SM (2017) Organelles and chromatin fragmentation of human umbilical vein endothelial cell influence by the effects of zeta potential and size of silver nanoparticles in different manners. Artif Cells Nanomed Biotechnol 45:817–823

    CAS  Google Scholar 

  • Temkin V, Huang Q, Liu H, Osada H, Pope RM (2006) Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis. Mol Cell Biol 26:2215–2225

    CAS  Google Scholar 

  • Templeton DM, Liu Y (2010) Multiple roles of cadmium in cell death and survival. Chem Biol Interact 188:267–275

    CAS  Google Scholar 

  • Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, Zachariou A, Lopez J, MacFarlane M, Cain K, Meier P (2011) The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell 43:432–448

    CAS  Google Scholar 

  • Tran QH, Le A-T (2013) Silver nanoparticles: synthesis, properties, toxicology, applications and perspectives. Adv Nat Sci Nanosci Nanotechnol 4:033001

    Google Scholar 

  • Ullenhag GJ, Mukherjee A, Watson NF, Al-Attar AH, Scholefield JH, Durrant LG (2007) Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patients. Clin Cancer Res 13:5070–5075

    CAS  Google Scholar 

  • Upton JW, Chan FK-M (2014) Staying alive: cell death in antiviral immunity. Mol Cell 54:273–280

    CAS  Google Scholar 

  • Upton JW, Kaiser WJ, Mocarski ES (2012) DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe 11:290–297

    CAS  Google Scholar 

  • Vanlangenakker N, vanden Berghe T, Bogaert P, Laukens B, Zobel K, Deshayes K, Vucic D, Fulda S, Vandenabeele P, Bertrand MJM (2011) cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ 18:656–665

    CAS  Google Scholar 

  • Veyer DL, Carrara G, de Motes CM, Smith GL (2017) Vaccinia virus evasion of regulated cell death. Immunol Lett 186:68–80

    CAS  Google Scholar 

  • Wang Y-Q, Wang L, Zhang MY, Wang T, Bao HJ, Liu WL, Dai DK, Zhang L, Chang P, Dong WW, Chen XP, Tao LY (2012) Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model. Neurochem Res 37:1849–1858

    CAS  Google Scholar 

  • Wang B, Zhang Y, Mao Z, Yu D, Gao C (2014a) Toxicity of ZnO nanoparticles to macrophages due to cell uptake and intracellular release of zinc ions. J Nanosci Nanotechnol 14:5688–5696

    CAS  Google Scholar 

  • Wang H et al (2014b) Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell 54:133–146

    CAS  Google Scholar 

  • Wang X, Li Y, Liu S, Yu X, Li L, Shi C, He W, Li J, Xu L, Hu Z, Yu L, Yang Z, Chen Q, Ge L, Zhang Z, Zhou B, Jiang X, Chen S, He S (2014c) Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense. Proc Natl Acad Sci 111:15438–15443

    CAS  Google Scholar 

  • Wang Y, Wang H, Tao Y, Zhang S, Wang J, Feng X (2014d) Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury. Neuroscience 266:91–101

    CAS  Google Scholar 

  • Wei X, Shao B, He Z, Ye T, Luo M, Sang Y, Liang X, Wang W, Luo S, Yang S, Zhang S, Gong C, Gou M, Deng H, Zhao Y, Yang H, Deng S, Zhao C, Yang L, Qian Z, Li J, Sun X, Han J, Jiang C, Wu M, Zhang Z (2015) Cationic nanocarriers induce cell necrosis through impairment of Na+/K + -ATPase and cause subsequent inflammatory response. Cell Res 25:237–253

    CAS  Google Scholar 

  • Wu Y-L, He Y, Shi J-J, Zheng T-X, Lin X-J, Lin X (2019) Microcystin-LR promotes necroptosis in primary mouse hepatocytes by overproducing reactive oxygen species. Toxicol Appl Pharmacol:114626

  • Xia T et al (2006) Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 6:1794–1807

    CAS  Google Scholar 

  • Xie C, Zhang N, Zhou H, Li J, Li Q, Zarubin T, Lin SC, Han J (2005) Distinct roles of basal steady-state and induced H-ferritin in tumor necrosis factor-induced death in L929 cells. Mol Cell Biol 25:6673–6681

    CAS  Google Scholar 

  • Xu X, Chua CC, Kong J, Kostrzewa RM, Kumaraguru U, Hamdy RC, Chua BH (2007) Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells. J Neurochem 103:2004–2014

    CAS  Google Scholar 

  • Xu F et al (2018) Necroptosis contributes to urban particulate matter-induced airway epithelial injury. Cell Physiol Biochem 46:699–712

    CAS  Google Scholar 

  • Yamanaka K, Saito Y, Yamamori T, Urano Y, Noguchi N (2011) 24 (S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis. J Biol Chem 286:24666–24673

    CAS  Google Scholar 

  • Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, Krönke M (2009) Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature 460:1159–1163

    CAS  Google Scholar 

  • Ye Y-C, Wang H-J, Yu L, Tashiro S-I, Onodera S, Ikejima T (2012) RIP1-mediated mitochondrial dysfunction and ROS production contributed to tumor necrosis factor alpha-induced L929 cell necroptosis and autophagy. Int Immunopharmacol 14:674–682

    CAS  Google Scholar 

  • Zanganeh S et al (2019) Immunoengineering in glioblastoma imaging and therapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol:e1575

  • Zhang D-W, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J (2009) RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325:332–336

    CAS  Google Scholar 

  • Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ (2010) Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464:104–107

    CAS  Google Scholar 

  • Zhang Y-F, He W, Zhang C, Liu XJ, Lu Y, Wang H, Zhang ZH, Chen X, Xu DX (2014) Role of receptor interacting protein (RIP) 1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice. Toxicol Lett 225:445–453

    CAS  Google Scholar 

  • Zhang L, Wei J, Ren L, Zhang J, Yang M, Jing L, Wang J, Sun Z, Zhou X (2017) Endosulfan inducing apoptosis and necroptosis through activation RIPK signaling pathway in human umbilical vascular endothelial cells. Environ Sci Pollut Res 24:215–225

    CAS  Google Scholar 

  • Zhang L, Feng Q, Wang T (2018) Necrostatin-1 protects against Paraquat-induced cardiac contractile dysfunction via RIP1-RIP3-MLKL-dependent necroptosis pathway. Cardiovasc Toxicol 18:346–355

    CAS  Google Scholar 

  • Zhang Q, Wang S, Zheng S, Zhang Z, Xu S (2019) Chlorpyrifos suppresses neutrophil extracellular traps in carp by promoting necroptosis and inhibiting respiratory burst caused by the PKC/MAPK pathway. Oxidative Med Cell Longev:2019

  • Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J, Liu Z-G (2012) Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc Natl Acad Sci 109:5322–5327

    CAS  Google Scholar 

  • Zhu S, Zhang Y, Bai G, Li H (2011) Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease. Cell Death Dis 2:e115

    CAS  Google Scholar 

Download references

Funding

This study was supported by the University of Zabol, Zabol, Iran, (UOZ-GR-9618-5) received by the corresponding author Dr. N. Sanadgol.

Author information

Authors and Affiliations

  1. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad-Reza Sepand & Yazdan Hasani-Nourian

  2. Department of Toxicology and Pharmacology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran

    Mehdi Aliomrani

  3. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Mohammad-Reza Khalhori & Mohammad-Hosein Farzaei

  4. Department of Biology, Faculty of Sciences, University of Zabol, Zabol, Iran

    Nima Sanadgol

  5. Department of Biomolecular Sciences, School of Pharmaceutical Sciences, University of São Paulo, Ribeirão Preto, Brazil

    Nima Sanadgol

Authors
  1. Mohammad-Reza Sepand
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mehdi Aliomrani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yazdan Hasani-Nourian
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mohammad-Reza Khalhori
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mohammad-Hosein Farzaei
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Nima Sanadgol
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

M-R Sepand and N. Sanadgol conceived the study and designed the study; M-R Sepand, M. Aliomrani, and Y. Hasani-Nourian conducted the searches; N. Sanadgol, M-H Farzaei, and M-R Kalhori interpreted the finding; all authors contributed in writing and commented on the manuscript.

Corresponding author

Correspondence to Nima Sanadgol.

Ethics declarations

Ethical approval and consent to participate

Not applicable

Consent for publication

Not applicable

Availability of supporting data

Not applicable

Conflict of interests

The authors declare that they have no competing interests.

Additional information

Responsible Editor: Lotfi Aleya

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Highlights

• Necroptosis can be triggered in response to the activation of multiple cell-surface receptors.

• Abnormal and extreme activation of necroptosis may be concerned with cellular/tissue damage and ultimately lead to pathological abnormalities.

• Air pollutants, pesticides, nanoparticles, and tobacco smoke could potentially mediate chemicals-induced necroptosis.

• Cell type, exposure duration, and does play an essential role in chemicals-induced necroptosis.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sepand, MR., Aliomrani, M., Hasani-Nourian, Y. et al. Mechanisms and pathogenesis underlying environmental chemical-induced necroptosis. Environ Sci Pollut Res 27, 37488–37501 (2020). https://doi.org/10.1007/s11356-020-09360-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11356-020-09360-5

Keywords

Search

Navigation