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The independent and combined association of napping and night sleep duration with stroke in Chinese rural adults

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Background

Inappropriate sleep duration is a potential cause of stroke. But the effect of napping on stroke risk remains controversial and the interaction between night sleep and napping duration remains unclear. The objective of this study was to examine the independent and combined effects of napping and nocturnal sleep duration on stroke.

Methods

Subjects were derived from a rural cohort study in Henan. The Pittsburgh Sleep Quality Index (PSQI) was applied to identify nap duration and nocturnal sleep duration. Binary logistic regression was employed to indicate the dose–response relationships between naps, nocturnal sleep, total 24-h sleep duration, and stroke.

Results

Among the 37,341 participants (14,485 men), 2600 suffered from a stroke. The odds ratios (ORs) and 95% confidence level (CI) for stroke in the fully adjusted model were 1.37 (1.13–1.65) for men nappers compared to non-nappers. Compared to 7–8 h of sleep per day, night sleep durations < 6 h and ≥ 9 h and 24-h sleep duration ≥ 10 h were linked to increased odds of stroke in men. The ORs (95%CI) were 1.34 (1.06–1.69) in nocturnal sleep duration < 6 h, 1.30 (1.06–1.59) in nocturnal sleep duration ≥ 9 h, and 1.40 (1.15–1.71) in 24-h sleep duration ≥ 10 h in men. In addition, long naps and prolonged nocturnal sleep duration have a joint effect on stroke in the fully adjusted model.

Conclusion

The napping duration and nocturnal sleep duration have independently and jointly effects on stroke in rural populations. More research is required to explore the underlying mechanisms for this relationship.

Clinical trial registration

The Henan Rural Cohort Study has been registered on the Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699) (http://www.chictr.org.cn/showproj.aspx?proj=11375).

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors thank all of the participants, coordinators, and administrators for their support and help during the research. In addition, the authors would like to thank Dr. Tanko Abdulai for his critical reading of the manuscript.

Funding

This research was supported by the Foundation of National Key Program of Research and Development of China (Grant NO: 2016YFC0900803), Science and Technology Innovation Team Support Plan of Colleges and Universities in Henan Province (Grant NO:21IRTSTHN029), National Natural Science Foundation of China (Grant NO: 81573243, 81930092), Foundation of Medical Science and Technology of Henan province (NO: 201702367, 2017T02098), and Discipline Key Research and Development Program of Zhengzhou University (Grant NO: XKZDQY202008, XKZDQY202002). The funders had no role in the study design, data collection, and analysis, decision to publish, or preparation of the manuscript.

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Author notes

  1. Jing Yang and Xiaotian Liu are contributed equally to this work.

Authors and Affiliations

  1. Department of Clinical Pharmacology, School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China

    Jing Yang & Yuqian Li

  2. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People’s Republic of China

    Jing Yang, Xiaotian Liu, Zhihan Zhai, Wei Liao, Yaling He, Xueyan Wu, Chongjian Wang & Yuqian Li

  3. Department of Preventive Medicine, Henan University of Chinese Medicine, Zhengzhou, Henan, People’s Republic of China

    Chunyang Sun

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  1. Jing Yang
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Contributions

Chongjian Wang and Yuqian Li conceived and designed the experiments. Jing Yang, Xiaotian Liu, Zhihan Zhai, Wei Liao, Yaling He, and Xueyan Wu gathered data. Jing Yang and Xiaotian Liu analyzed the data. Jing Yang drafted the manuscript. Xiaotian Liu, Zhihan Zhai, Wei Liao, Yaling He, and Xueyan Wu modified the manuscript. All of the authors contributed to the revision of the manuscript and approved the final manuscript.

Corresponding author

Correspondence to Yuqian Li.

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Ethics approval was obtained from the “Zhengzhou University Life Science Ethics Committee”, and written informed consent was obtained for all participants. Ethics approval code: [2015] MEC (S128).

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Yang, J., Liu, X., Zhai, Z. et al. The independent and combined association of napping and night sleep duration with stroke in Chinese rural adults. Sleep Breath 27, 265–274 (2023). https://doi.org/10.1007/s11325-022-02619-w

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  • DOI: https://doi.org/10.1007/s11325-022-02619-w

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