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Analysis of the proportion and clinical characteristics of obstructive sleep apnea in women with polycystic ovary syndrome

  • Epidemiology • Original Article
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Abstract

Purpose

To investigate the proportion and clinical characteristics of obstructive sleep apnea (OSA) in Chinese patients with polycystic ovarian syndrome (PCOS) through home sleep apnea test (HSAT) and to evaluate the reproductive endocrine and metabolic characteristics in these patients.

Methods

The study was a cross-sectional analysis of infertile PCOS patients who underwent sleep respiratory monitoring between January and December 2019 at Peking University Third Hospital Reproductive Medical Center and respiratory and critical care medicine department. The prevalence of OSA, body mass index (BMI), menstruation, reproductive endocrine, and metabolic characteristics were collected in patients with PCOS. Logistic regression was performed to identify significant relationships among these factors and OSA.

Results

Amont 328 patients with PCOS, the prevalence of OSA was 40% (131/328), and six cases (5%) were severe. Univariate analysis showed that BMI and blood pressure were significantly higher in patients with OSA than in those without OSA (P < 0.05), whereas the anti-Mullerian hormone was lower than that in patients without OSA. In terms of glucose and lipid metabolism, the glycosylated hemoglobin (HbA1c), fasting plasma glucose, and fasting insulin levels were significantly higher in patients with PCOS and comorbid OSA than in those without OSA (all P < 0.05). Patients with OSA also had higher triglyceride, low-density lipoprotein cholesterol, and high-sensitivity C-reactive protein levels and lower high-density lipoprotein cholesterol levels (P < 0.05). Logistic regression analysis revealed that higher BMI, elevated serum testosterone, and decreased high-density lipoprotein cholesterol (HDL-C) are correlated with occurrence of OSA (P < 0.05).

Conclusion

OSA in patients with PCOS was associated with multiple alterations in indexes of reproductive endocrine and metabolic disorders.

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Funding

This research was supported by the National Key Research and Development Program (grant No. 2018YFC1002106) and the Key Clinical Research Project of Peking University Third Hospital “Effect of obstructive sleep apnea syndrome on clinical phenotype and outcome of assisted reproductive pregnancy in polycystic ovary syndrome” (grant No. BYSY2018016).

Author information

Authors and Affiliations

  1. Reproductive Medical Center, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China

    Rui Yang, Chang Gao, Yizhi Yan, Chunmei Zhang, Xiaowei Ma, Nannan Li, Xiaoguo Du, Ying Wang, Rong Li & Jie Qiao

  2. Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China

    Yongwei Huang, Jianli Wang & Liqiang Zhang

Authors
  1. Rui Yang
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  2. Chang Gao
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  3. Yizhi Yan
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  4. Yongwei Huang
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  5. Jianli Wang
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  6. Chunmei Zhang
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  10. Liqiang Zhang
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Corresponding authors

Correspondence to Liqiang Zhang or Ying Wang.

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Ethical approval

All procedures were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards and the study was approved by the Ethical Committee of Peking University Third Hospital (Beijing, China). (IRB00006761-M2020391).

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Cite this article

Yang, R., Gao, C., Yan, Y. et al. Analysis of the proportion and clinical characteristics of obstructive sleep apnea in women with polycystic ovary syndrome. Sleep Breath 26, 497–503 (2022). https://doi.org/10.1007/s11325-021-02376-2

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  • DOI: https://doi.org/10.1007/s11325-021-02376-2

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