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Effect of preoperative single-dose methylprednisolone administration on early postoperative pain following retrograde intrarenal surgery

  • Urology - Original Paper
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Abstract

Purpose

To evaluate the effect of preoperative single-dose methylprednisolone use on postoperative early pain after retrograde intrarenal surgery (RIRS).

Methods

Patients who had 10–20 mm solitary kidney stones and underwent RIRS procedures were included in this prospective cohort study between February 2022 and May 2023. Patients who were administered methylprednisolone at a dose of 1 mg/kg preoperatively were included in group 1 (n: 31), and the other first 90 patients who met the inclusion criteria and did not receive methylprednisolone before surgery were included in group 2 (n: 90). Demographic data, features of stone, postoperative pain at 1, 6, 12, 18, and 24 hour, the need for analgesics, changes in serum glucose levels, and the prevalence of postoperative fever were compared.

Results

Age, sex, stone laterality, localization, size, Hounsfield Unit, modified Satava scores, stone-free status, duration of the RIRS procedure, and duration of the ureteral access sheath were found to be similar between groups. Visual Analog Scale (VAS) scores at postoperative 1, 6, 12, 18, and 24 h were found to be statistically significantly lower in group 1 (p = .001, p = .001, p = .001, p = .001, and p = .001, respectively). Similarly, postoperative analgesic requirements were found to be significantly lower in group 1 (p = .048) with a similar postoperative fever rate and changes in serum glucose levels between groups.

Conclusion

Giving a single dose of methylprednisolone at a dose of 1 mg/kg preoperatively for the RIRS procedure is safe and effective at preventing early pain and the need for analgesics after the RIRS procedure.

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Data availability statement

The dataset used and analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

The authors declare that they have no relevant financial interests.

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Authors and Affiliations

  1. Department of Urology, Başaksehir Çam and Sakura City Hospital, Istanbul, Turkey

    Emin Taha Keskin, Muammer Bozkurt, Mehmet Şahin, Harun Özdemir, Çağrı Şevik & Halil Lutfi Canat

Authors
  1. Emin Taha Keskin
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  2. Muammer Bozkurt
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  3. Mehmet Şahin
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  4. Harun Özdemir
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  5. Çağrı Şevik
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  6. Halil Lutfi Canat
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Contributions

ETK: corresponding author, protocol and project development, data analysis, and manuscript writing. MB: project development, data analysis, and manuscript writing. MŞ: project development, data analysis, and manuscript writing. HÖ: project development, manuscript writing and editing. ÇŞ: project development, data analysis. HLC: project development and editing.

Corresponding author

Correspondence to Emin Taha Keskin.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval for research involving human participants

The study was approved by the local ethics committee (Institutional Review Board approval no: KAEK/2022.01.18) at University of Health Sciences Basaksehir Cam and Sakura City Hospital. All procedures performed in our study involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards and this study was designed according to the STROCSS 2021 criteria.

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Keskin, E.T., Bozkurt, M., Şahin, M. et al. Effect of preoperative single-dose methylprednisolone administration on early postoperative pain following retrograde intrarenal surgery. Int Urol Nephrol 56, 1253–1258 (2024). https://doi.org/10.1007/s11255-023-03875-9

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  • DOI: https://doi.org/10.1007/s11255-023-03875-9

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