Abstract
Purpose
Holmium laser enucleation of the prostate (HoLEP) is reported to be widely used in the surgical treatment of benign prostatic hyperplasia (BPH), which consists of two procedures: enucleation and morcellation. This study is to examine the efficiency and safety of two different morcellator systems within a cohort of men undergoing HoLEP for BPH.
Methods
A total of 210 consecutive patients undergoing HoLEP and morcellation procedures were enrolled. Individuals were randomly divided into 2 separated groups: the first group (105 patients) was performed with a nephroscope using a mechanical Versacut morcellator and the second (105 patients) was performed with the new morcellation system, nephroscopes and Piranha morcellator. Perioperative characteristics were studied and analyzed.
Results
The morcellation time and the morcellation rate was similar when the prostate volume (PV) ≤ 60 mL while the morcellation time was significantly shorter and the morcellation rate was higher in the Piranha group with PV > 60 mL. No significant difference was observed according to the bladder irrigation time, indwelling catheter time, and discharge time.
Conclusion
Piranha morcellator presents a higher efficiency for the prostate over 60 mL.
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Data availability
All of the data included in this research are available if needed.
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Funding
This study is sponsored by Shanghai Sailing Program (21YF1423300); Natural Science Foundation of Shanghai (21ZR1437800); Cross-disciplinary Research Fund of Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine (YG2021QN75), grants from the Multi-center clinical research project of Shanghai JiaoTong University School of Medicine (DLY201809), Shanghai Huangpu District Industry Support Fund (XK2020011) and National Natural Science Foundation of China (81902616).
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Conception and design: YC, HX, DG; administrative support: ZW, QC, MZ; provision of study materials or patients: MG, CL, ZC; collection and assembly of data: YC; data analysis and interpretation: HX, DG; manuscript writing: all authors; final approval of manuscript: all authors.
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This project was approved by the Clinical Research Ethics Committee of Shanghai ninth people’s Hospital associated with Shanghai Jiaotong University.
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Chen, Y., Xu, H., Gao, D. et al. A prospective randomized controlled trial comparing the effect and safety of Piranha and VersaCut morcellation devices in transurethral holmium laser enucleation of the prostate. Int Urol Nephrol 54, 2977–2981 (2022). https://doi.org/10.1007/s11255-022-03218-0
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DOI: https://doi.org/10.1007/s11255-022-03218-0