Abstract
In order to find mitochondria-targeted mimics of catalase that can attenuate the metabolism of oxygen for cancer chemotherapy, two complexes [Mn(QA)Cl2] and [Mn(QA)(OAc)(H2O)2](OAc) (QA = 2-di(picolyl)amine-N-(quinoline-8-yl)acetamide) were synthesized and characterized by spectroscopic methods. In addition, the crystal structure of [Mn(QA)Cl2] shows that the Mn(II) atom is coordinated by three N atoms (N1, N2,and N3), and one oxygen atom (O1) of the ligand QA, plus two chloride atoms (Cl1 and Cl2), forming a distorted octahedral geometry. The complex [Mn(QA)(OAc)(H2O)2](OAc) could disproportionate H2O2 in Tris–HCl solution at 37 °C, with K cat/K M = 9,226. Furthermore, both Mn(II) complexes were found to be active against the proliferation of HepG-2 cells and could attenuate the swelling of calcium-overloaded mitochondria. These results demonstrate that Mn(II) complexes of quinoline derivatives have potential as attenuators of the absorption of Ca2+ in mitochondria and can interfere with the metabolism of O2 for cancer chemotherapy.
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We thank the financial support from National Science Foundation of China (21271090).
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Wang, ZW., Chen, QY. & Liu, QS. Manganese(II) complexes of quinoline derivatives: characterization, catalase activity, interaction with mitochondria and anticancer activity. Transition Met Chem 39, 917–924 (2014). https://doi.org/10.1007/s11243-014-9876-z
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DOI: https://doi.org/10.1007/s11243-014-9876-z