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Synthesis and study of complexes of cobalt(II), nickel(II), and copper(II) halides with 2-(3,5-dimethylpyrazol-1-yl)benzimidazole

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Abstract

New coordination compounds of cobalt(II), nickel(II), and copper(II) halides with 2-(3,5-dimethylpyrazol-1-yl)benzimidazole (L) of the composition [CoLCl2] (1), CoL2Cl2 · 2H2O · EtOH (2), [NiL(H2O)4]Cl2 · H2O · EtOH (3), NiL2Cl2 · 2H2O · EtOH (4), and [CuL2Br]Br · H2O (5) were synthesized. The compounds were characterized by electronic (diffuse reflectance) spectroscopy, IR spectroscopy, and powder X-ray diffraction. The crystal structures of compounds 1, 3, and 5 were determined by single-crystal X-ray diffraction. The cytotoxic properties of the ligand and compound 5 were evaluated in the Hep-2 cell line.

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Authors and Affiliations

  1. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 3 prosp. Akad. Lavrentieva, 630090, Novosibirsk, Russian Federation

    A. D. Ivanova, V. Yu. Komarov, L. A. Glinskaya, L. A. Sheludyakova & L. G. Lavrenova

  2. Institute of Physical and Organic Chemistry, Southern Federal University, 194/2 prosp. Stachki, 344090, Rostov-on-Don, Russian Federation

    T. A. Kuz’menko

  3. Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, 2/12 ul. Timakova, 630060, Novosibirsk, Russian Federation

    L. S. Klyushova

Authors
  1. A. D. Ivanova
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  2. T. A. Kuz’menko
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  3. V. Yu. Komarov
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  4. L. A. Glinskaya
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  5. L. A. Sheludyakova
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  6. L. S. Klyushova
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  7. L. G. Lavrenova
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Corresponding author

Correspondence to L. G. Lavrenova.

Additional information

This work was financially supported in part by the Russian Science Foundation (Project No. 20-63-46026) and the Ministry of Science and Higher Education of the Russian Federation (state assignment for the Southern Federal University No. FENW-2020-0031 (0852-2020-0031)).

Cytotoxicity assays were carried out at the Joint Access Center “Proteomic Analysis” of the Institute of Molecular Biology and Biophysics of the Federal Research Center of Fundamental and Translational Medicine (IMBB FRC FTM).

We are grateful to N. P. Korotkevich for measuring powder X-ray diffraction patterns and I. V. Yushina for recording diffuse reflectance spectra.

This paper does not contain descriptions of studies on animals or humans.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1550–1559, August, 2021.

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Ivanova, A.D., Kuz’menko, T.A., Komarov, V.Y. et al. Synthesis and study of complexes of cobalt(II), nickel(II), and copper(II) halides with 2-(3,5-dimethylpyrazol-1-yl)benzimidazole. Russ Chem Bull 70, 1550–1559 (2021). https://doi.org/10.1007/s11172-021-3251-y

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  • DOI: https://doi.org/10.1007/s11172-021-3251-y

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