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Synthesis of 8-oxa-2-azaspiro[4.5]decane

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Abstract

A convenient synthesis of new 8-oxa-2-azaspiro[4.5]decane from commercially available reagents based on tetrahydropyran-4-carbonitrile and 1-bromo-2-fluoroethane has been developed. This compound is promising for the production of important biologically active compounds.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    V. A. Ogurtsov & O. A. Rakitin

Authors
  1. V. A. Ogurtsov
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  2. O. A. Rakitin
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Correspondence to O. A. Rakitin.

Additional information

Russian Chemical Bulletin, International Edition, Vol. 69, No. 10, pp. 2017–2019, October, 2020

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 2017–2019, October, 2020.

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Ogurtsov, V.A., Rakitin, O.A. Synthesis of 8-oxa-2-azaspiro[4.5]decane. Russ Chem Bull 69, 2017–2019 (2020). https://doi.org/10.1007/s11172-020-2994-1

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  • DOI: https://doi.org/10.1007/s11172-020-2994-1

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