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Variables associated with poor health-related quality of life among patients with dyslipidemia in Jordan

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Abstract

Purpose

The study aim was to evaluate HRQOL and to explore the variables associated with poor HRQOL among patients with dyslipidemia in Jordan.

Methods

The present study utilized the EQ-5D questionnaire which evaluates HRQOL in terms of mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Responses to the five dimensions were presented using the value set, which ranges from 1 for full health to − 0.594 for severe problems in all five dimensions. Multiple linear regression analysis was implemented to identify the variables that best predicted the total EQ-5D score and hence HRQOL in the study population.

Results

The mean age of the 228 participants was 60.23 (SD = 10.64). The mean of the total EQ-5D score was 0.675 (SD = 0.14). Regression analysis identified necessity for dyslipidemia medication (B = 0.18, P < 0.01) and patients with controlled lipid profile (B = 0.28, P < 0.01) were positively associated with HRQOL, while having concerns about dyslipidemia medications (B = − 0.16, P < 0.01), number of medication (B = − 0.13, P = 0.02), duration of dyslipidemia (B = − 0.22, P < 0.01), receiving high-intensity statin (B = − 0.18, P < 0.01) or statin in combination with fibrate (B = − 0.15, P < 0.01) were associated with lower HRQOL.

Conclusion

HRQOL has considerable scope for improvement in patients with dyslipidemia in Jordan. Improving dyslipidemia medications’ beliefs and simplifying medication regimen by prescribing less medications, particularly for patients with longer disease duration and those on statin therapy, should be considered in future management programs aim at improving HRQOL in patients with dyslipidemia.

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Acknowledgements

The authors wish to express their gratitude for the medical staff at the Cardiology Center in King Abdullah Hospital, University of Jordan Hospital, and the Royal Medical Services Hospital for facilitating the implementation of this research study.

Funding

This research did not receive any specific grant or fund from any resource.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan

    Anan S. Jarab, Tareq L. Mukattash & Lina Abu-Zaytoun

  2. Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Amman, Jordan

    Eman A. Alefishat

  3. Department of Pharmacology, College of Medicine and Health Science, Khalifa University, Abu Dhabi, United Arab Emirates

    Eman A. Alefishat

  4. Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates

    Eman A. Alefishat

  5. Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, P.O. Box 130, Amman, 11733, Jordan

    Walid Al-Qerem

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  1. Anan S. Jarab
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Correspondence to Anan S. Jarab.

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Jarab, A.S., Alefishat, E.A., Al-Qerem, W. et al. Variables associated with poor health-related quality of life among patients with dyslipidemia in Jordan. Qual Life Res 30, 1417–1424 (2021). https://doi.org/10.1007/s11136-020-02726-9

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