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Risk factors for potentially inappropriate medication use in older adults: a cohort study

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Abstract

Background

Much of the knowledge on the use of potentially inappropriate medications (PIM) in older adults is derived from cross-sectional studies, with little known about the risk factors over time.

Aim

Longitudinal analysis was applied to estimate the occurrence and risk factors of PIM use among older adults in a 10-year follow-up.

Method

Longitudinal study with 418 older adult residents of a capital city of Central-West Brazil. The PIM were classified according to the Beers criteria 2019. The usage rate was calculated at baseline (2008) and at the 10-year follow-up moment (2018). Analysis of predictors (sociodemographic, self-rated health, hospitalization, number of comorbidities, polypharmacy, diabetes, hypertension, hypercholesterolemia and nutritional status) was performed using Generalized Estimating Equation (GEE) models.

Results

Mean age at baseline was 70.6 years (SD 7.1) and 76% were women; 221 older adults took part in the follow up. The rate of PIM use was 50.4% at baseline and 57.5% at the 10-year follow-up. Multiple analysis showed that PIM use in the cohort was statistically higher in the older adults with a history of hospitalization (RRadj 1.20; 95% CI 1.01–1.40), with three or more diseases (RRadj 1.41; 95% CI 1.14–1.74), with polypharmacy (RRadj 1.81; 95% CI 1.47–2.24) and with diabetes mellitus (RRadj 1.24; 95% CI 1.05–1.47).

Conclusion

A high level of potentially inappropriate medication use was observed, reaching 50% of the older adults, with a 7% increase in the prevalence over the 10-year follow-up period. Hospitalization, multimorbidities, polypharmacy and diabetes mellitus were associated with the use of these medications. Interventions for surveillance of the deprescribing process need to be encouraged to avoid potential harm caused by the use of medications.

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Funding

This study was supported by the National Council for Scientific and Technological Development of Brazil (CNPq), Grant no. 428635/2016–4, and in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001.

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Authors and Affiliations

  1. Postgraduate Program in Nursing, Faculty of Nursing, Federal University of Goiás, PPGENF/FEN/UFG, Rua 227 Qd. 68 s/n - Setor Universitário, Goiânia, Goiás, CEP 74605-080, Brazil

    Natacha Christina de Araújo, Rafael Alves Guimarães & Valéria Pagotto

  2. Postgraduate Program in Health Sciences, Faculty of Medicine, Federal University of Goiás, Goiânia, Goiás, Brazil

    Erika Aparecida Silveira

  3. Faculty of Nursing, Federal University of Goiás, Goiânia, Goiás, Brazil

    Brenda Godoi Mota

  4. Hospital das Clínicas, Federal University of Goiás, Goiânia, Goiás, Brazil

    Ana Carolina Figueiredo Modesto

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  1. Natacha Christina de Araújo
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  2. Erika Aparecida Silveira
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  3. Brenda Godoi Mota
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  4. Rafael Alves Guimarães
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  5. Ana Carolina Figueiredo Modesto
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  6. Valéria Pagotto
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Correspondence to Valéria Pagotto.

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de Araújo, N.C., Silveira, E.A., Mota, B.G. et al. Risk factors for potentially inappropriate medication use in older adults: a cohort study. Int J Clin Pharm 44, 1132–1139 (2022). https://doi.org/10.1007/s11096-022-01433-4

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